在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Translocation protein SEC62 (SEC62), partial

Recombinant Human Translocation protein SEC62 (SEC62), partial

  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-YP857446HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-EP857446HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-EP857446HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-BP857446HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-MP857446HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SEC62; TLOC1; Translocation protein SEC62; Translocation protein 1; TP-1; hTP-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
  • 基因功能參考文獻：
    1. Results show higher SEC62 in the lymph node metastases from head and neck squamous cell carcinomas and cervical cancer of unknown primary patients compared with the primary tumor. Tumors from N1 to N3 stage exhibit increasing SEC62 expression in the lymphatic metastases. Its knockdown resulted in tumor cell line migration inhibition while, its overexpression stimulated cell migration. PMID: 28002801
    2. High Sec62 expression is associated with dysplastic cervical lesions. PMID: 27553742
    3. identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis PMID: 27749824
    4. these studies identify TLOC1 and SKIL as driver genes at 3q26 and more broadly suggest that cooperating genes may be coamplified in other regions with somatic copy number gain. PMID: 23764425
    5. Sec62 overproduction significantly correlates with reduced non-small lung cancer patient survival. PMID: 24304694
    6. Phosphorylation of Sec63 by CK2 enhanced its binding to Sec62 PMID: 23287549
    7. Silencing the SEC62 gene inhibits post-translational transport of small presecretory proteins into endoplasmic reticulum. PMID: 22375059
    8. the Sec62-dependent translocation pathway serves as a fail-safe mechanism to ensure efficient secretion of small proteins and provides cells with an opportunity to regulate secretion of small proteins independent of the signal recognition particle pathway PMID: 22648169
    9. These results revealed that cyclin B1 and Sec62 may be candidate biomarkers and potential therapeutic targets for HBV-related HCC recurrence after surgery. PMID: 22682366
    10. The results indicate that SEC62 represents a potential candidate oncogene in the amplified 3q region in cases of non-small cell lung cancer. PMID: 22197383
    11. Our data indicate a crucial function of Sec62 in the response to thapsigargin-induced endoplasmic reticulum stress. PMID: 21557272
    12. after silencing of SEC62 the cell migration and the invasive potential of the cells was blocked or at least dramatically reduced while cell viability was hardly affected. SEC62 gene may indeed be considered a target gene in the therapy of various tumors PMID: 20669223
    13. The gene TLOC1/SEC62 revealed the highest frequency (50%) of copy number gains in the prostate cancer and was found to be up-regulated at the mRNA level. PMID: 16547154

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SEC62 family
  • 數據庫鏈接：

    HGNC: 11846

    OMIM: 602173

    KEGG: hsa:7095

    STRING: 9606.ENSP00000337688

    UniGene: Hs.744859



主站蜘蛛池模板： 2021年国产精品专区丝袜| 久久久久黑人强伦姧人妻| 亚洲精品国产第一综合99久久| 全免费又大粗又黄又爽少妇片| 少妇又紧又色又爽又刺激视频| 综合在线 亚洲 成人 欧美| 日本道免费精品一区二区| 亚洲中文无码人a∨在线| 插我一区二区在线观看| 国产精品a成v人在线播放| 成人欧美一区二区三区a片| 亚洲熟妇丰满xxxxx| 成年美女黄网站色大片免费看 | 疯狂撞击丝袜人妻| 亚洲一区二区女搞男| 精品国产一区二区三区av孞弋| 欧美日韩一本的免费高清视频| 国产全肉乱妇杂乱视频| 精品一区二区三区在线成人| 人妻丝袜中文无码av影音先锋专区 | 亚洲va综合va国产产va中| 黑人巨大精品欧美黑寡妇| 8av国产精品爽爽ⅴa在线观看| 国内无遮挡18禁无码网站免费| 国产麻豆精品福利在线观看| 欧美综合自拍亚洲综合图| 永久免费精品精品永久-夜色| 精品成人a区在线观看| 国产尤物在线视精品在亚洲| 国产午夜福利在线观看视频| 一本丁香综合久久久久不卡网站 | 中文在线中文a| 狠狠色噜噜狠狠狠8888在| 久久99国产精品久久| 久久天天躁夜夜躁狠狠85麻豆 | 综合人妻久久一区二区精品| 成人午夜看黄在线尤物成人| 中文国产成人精品久久久| 农村乱人伦一区二区| 亚洲一区二区三区成人网站| 亚洲最新版av无码中文字幕|