在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Translocation protein SEC62 (SEC62), partial

Recombinant Human Translocation protein SEC62 (SEC62), partial

  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-YP857446HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-EP857446HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-EP857446HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-BP857446HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SEC62重組蛋白
  • 貨號：
    CSB-MP857446HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SEC62; TLOC1; Translocation protein SEC62; Translocation protein 1; TP-1; hTP-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
  • 基因功能參考文獻：
    1. Results show higher SEC62 in the lymph node metastases from head and neck squamous cell carcinomas and cervical cancer of unknown primary patients compared with the primary tumor. Tumors from N1 to N3 stage exhibit increasing SEC62 expression in the lymphatic metastases. Its knockdown resulted in tumor cell line migration inhibition while, its overexpression stimulated cell migration. PMID: 28002801
    2. High Sec62 expression is associated with dysplastic cervical lesions. PMID: 27553742
    3. identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis PMID: 27749824
    4. these studies identify TLOC1 and SKIL as driver genes at 3q26 and more broadly suggest that cooperating genes may be coamplified in other regions with somatic copy number gain. PMID: 23764425
    5. Sec62 overproduction significantly correlates with reduced non-small lung cancer patient survival. PMID: 24304694
    6. Phosphorylation of Sec63 by CK2 enhanced its binding to Sec62 PMID: 23287549
    7. Silencing the SEC62 gene inhibits post-translational transport of small presecretory proteins into endoplasmic reticulum. PMID: 22375059
    8. the Sec62-dependent translocation pathway serves as a fail-safe mechanism to ensure efficient secretion of small proteins and provides cells with an opportunity to regulate secretion of small proteins independent of the signal recognition particle pathway PMID: 22648169
    9. These results revealed that cyclin B1 and Sec62 may be candidate biomarkers and potential therapeutic targets for HBV-related HCC recurrence after surgery. PMID: 22682366
    10. The results indicate that SEC62 represents a potential candidate oncogene in the amplified 3q region in cases of non-small cell lung cancer. PMID: 22197383
    11. Our data indicate a crucial function of Sec62 in the response to thapsigargin-induced endoplasmic reticulum stress. PMID: 21557272
    12. after silencing of SEC62 the cell migration and the invasive potential of the cells was blocked or at least dramatically reduced while cell viability was hardly affected. SEC62 gene may indeed be considered a target gene in the therapy of various tumors PMID: 20669223
    13. The gene TLOC1/SEC62 revealed the highest frequency (50%) of copy number gains in the prostate cancer and was found to be up-regulated at the mRNA level. PMID: 16547154

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SEC62 family
  • 數據庫鏈接：

    HGNC: 11846

    OMIM: 602173

    KEGG: hsa:7095

    STRING: 9606.ENSP00000337688

    UniGene: Hs.744859



主站蜘蛛池模板： 欧美国产日韩a在线视频| 亚洲国产精品美女久久久久| 黑人巨大精品欧美一区二区免费| 国产乱人伦精品一区二区| 精品乱码久久久久久中文字幕| 国产毛片不卡野外视频| 国产亚洲人成网站在线观看| 日本爽爽爽爽爽爽在线观看免 | 亚洲香蕉网久久综合影视| 无线乱码一二三区免费看| 免费观看又污又黄的网站| 国产亚洲人成a在线v网站| 午夜a理论片在线播放| 国产成人愉拍免费视频| 窝窝午夜看片| 俄罗斯美女真人性做爰| 天堂在/线中文在线资源8| 亚洲另类激情专区小说| 荫蒂被男人添的好舒服爽免费视频 | 国产成人免费永久在线平台| 无码人妻一区二区三区免费| 久久精品国产欧美日韩99热| 18禁免费吃奶摸下激烈视频| 成人性生交大片免费看视频app| 亚洲性夜夜天天天| 免费无码午夜福利片69| 中文字幕av无码一区二区三区电影| 久久99国产亚洲高清观看首页| 日产国产精品亚洲系列| 鲁一鲁av2019在线| 人妻av无码专区| 久久99成人免费| 亚洲国产精品无码中文在线| 四虎影视在线永久免费观看| 无码精品人妻一区二区三区影院 | 日本熟妇浓毛hdsex| 在线人人车操人人看视频| 少妇呻吟白浆高潮啪啪69| 国产成人精品一区二三区| 欧美性猛交xxxx黑人| 日韩人妻无码精品专区综合网|