在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Translation initiation factor eIF-2B subunit beta (EIF2B2)

  • 中文名稱:
    人EIF2B2重組蛋白
  • 貨號:
    CSB-EP007515HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    EIF2B2
  • Uniprot No.:
  • 別名:
    EI2BB_HUMAN; EIF 2Bbeta; EIF-2Bbeta; EIF2B; EIF2B GDP GTP exchange factor subunit beta; EIF2B2; EIF2B2; EIF2BB; Eukaryotic translation initiation factor 2B; Eukaryotic translation initiation factor 2B beta; Eukaryotic translation initiation factor 2B; subunit 2; Eukaryotic translation initiation factor 2B; subunit 2 beta; Eukaryotic translation initiation factor 2B; subunit 2 beta; 39kDa; S20I15; S20III15; Translation initiation factor eIF-2B subunit beta
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    66.0kDa
  • 表達區域:
    1-351aa
  • 氨基酸序列
    MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
  • 基因功能參考文獻:
    1. Data show that eIF2Balpha and eIF2Bbeta bind to adjacent surfaces on eIF2alpha-N-terminal domains (NTDs). PMID: 29036434
    2. It would be better to consider Vanishing White Matter Disease as an eIF2B-related multisystem disorder, not just as a neurological disorder. PMID: 28041799
    3. An Italian patient is described with a c.638A>G mutation in exon 5 of EIF2B2 gene with very slow progressive vanishing white matter disease. PMID: 22729508
    4. analysis of vanishing white matter disease caused by EIF2B2 mutation with the presentation of an adrenoleukodystrophy phenotype [case report] PMID: 22285377
    5. Mutation in EIF2B2 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy. PMID: 12707859
    6. Biochemical analyses indicate that mutations analyzed in eIF2Balpha and -epsilon reduce the steady-state level of the affected subunit, while the most severe mutant tested, eIF2Bbeta(V341D), forms complexes with reduced stability and lower eIF2B activity. PMID: 14993275
    7. The role of the residues Ser2 and Ser67 contribute to the important role of the N-terminal region of eIF2beta for its function in mammals. PMID: 16225457
    8. CACH syndrome is linked to mutations in the five EIF2B--REVIEW PMID: 17878805
    9. Study reports 9 novel mutations in EIF2B genes in 8 patients, increasing number of known mutations to >120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B protein (alpha, beta, gamma, delta, epsilon). PMID: 18263758

    顯示更多

    收起更多

  • 相關疾病:
    Leukodystrophy with vanishing white matter (VWM)
  • 蛋白家族:
    EIF-2B alpha/beta/delta subunits family
  • 數據庫鏈接:

    HGNC: 3258

    OMIM: 603896

    KEGG: hsa:8892

    STRING: 9606.ENSP00000266126

    UniGene: Hs.409137



主站蜘蛛池模板: 国产成人亚洲综合| 欧美乱妇xxxxxbbbbb| 亚洲欧美日韩成人一区在线| 欧美人与性动交α欧美精品| 成人性生交片无码免费看 | 香蕉精品亚洲二区在线观看| 精品无人乱码高清| 欧美成人a在线网站| 亚洲精品97久久中文字幕无码| 人妻无码中文字幕一区二区三区| 天堂在/线资源中文在线8 | h人成在线看免费视频| 成人免费无码不卡毛片视频| av鲁丝一区鲁丝二区鲁丝三区| 瑜伽裤国产一区二区三区| 国产av高清无亚洲| 久热爱精品视频线路一| 人妻中文乱码在线网站| 黄桃av无码免费一区二区三区| 亚洲在线国产日韩欧美| 日产精品卡1卡2卡三卡在线| √天堂中文最新版在线中文| 丁香花在线影院观看在线播放| 丁香五月激情综合色婷婷| 国产日韩综合av在线观看一区| 国产妇女馒头高清泬20p多| 亚洲综合一区无码精品| www激情内射在线看| 2020国产精品午夜福利在线观看 | 欧美熟妇xxxxx欧美老妇不卡| 浪荡女天天不停挨cao日常视频| 老熟女老太婆爽| 国产精品三级在线观看无码| 玩弄漂亮少妇高潮白浆| 男女啪啦猛视频免费| 秋霞特色aa大片| 青青草国产精品日韩欧美| 捆绑白丝粉色jk震动捧喷白浆| 天堂中文官网在线| 成人欧美一区二区三区1314| 人人妻人人爽人人做夜欢视频九色|