在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Transforming growth factor beta activator LRRC32 (LRRC32), partial

Recombinant Human Transforming growth factor beta activator LRRC32 (LRRC32), partial

  • 中文名稱：
    人LRRC32重組蛋白
  • 貨號：
    CSB-YP618886HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LRRC32重組蛋白
  • 貨號：
    CSB-EP618886HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LRRC32重組蛋白
  • 貨號：
    CSB-EP618886HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LRRC32重組蛋白
  • 貨號：
    CSB-BP618886HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LRRC32重組蛋白
  • 貨號：
    CSB-MP618886HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    D11S833E; GARP; Garpin; Glycoprotein A repetitions predominant; Leucine rich repeat containing 32; Leucine-rich repeat-containing protein 32; LRC32_HUMAN; LRRC32
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
  • 基因功能參考文獻：
    1. GARP is a surface molecule of regulatory T cells with roles in the regulatory function and TGF-beta releasing [review] PMID: 27095576
    2. Data show that the Treg activation marker GARP (glycoprotein A repetitions predominant) is expressed on primary melanoma. PMID: 27248166
    3. High GARP expression is associated with pancreatic cancer and liver metastases from colorectal cancer. PMID: 26885615
    4. study showed that stimulated, human B lymphocytes produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production. PMID: 28607112
    5. GARP plays an important role in the pathogenesis of atopic dermatitis. PMID: 27884290
    6. CD4(+) CD25(+) GARP(+) Treg cells are defective in dilated cardiomyopathy patients and GARP seems to be a better molecular definition of the regulatory phenotype. PMID: 28207945
    7. these results define the oncogenic effects of the GARP-TGFbeta axis in the tumor microenvironment PMID: 27913437
    8. LRRC32 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    9. GARP deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction. PMID: 26357016
    10. since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb PMID: 26584734
    11. GARP is regulated by miRNAs and controls latent TGF-beta1 production by human regulatory T cells. PMID: 24098777
    12. we investigated in detail miR-142-3 pregulation of GARP expression in regulatory CD25(+) CD4 T cells PMID: 23650616
    13. Findings support the idea that GARP is a new latent TGFbeta-binding protein that regulates the bioavailability of TGFbeta and provides a cell surface platform for alphaV integrin-dependent TGFbeta activation. PMID: 22278742
    14. There are 2 independent signals, one in C11orf30 and the other in LRRC32, that are strongly associated with serum IgE levels. C11orf30-LRRC32 region may represent a common locus for atopic diseases via pathways involved in regulation of serum IgE levels PMID: 22070912
    15. GARP is a key receptor controlling FOXP3 in T(reg) cells following T-cell activation in a positive feedback loop assisted by LGALS3 and LGMN PMID: 19453521
    16. the processing and expression of LRRC32 PMID: 21615933
    17. on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP) associated with asthma risk PMID: 21907864
    18. GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression PMID: 18628982
    19. Platelets and activated Tregs co-express latent TGF-beta and GARP on their membranes. PMID: 19651619
    20. Expression of GARP on activated regulatory T cells correlates with their suppressive capacity. PMID: 19666573
    21. Data show that latent TGF-beta, i.e. both LAP and mature TGF-beta, binds to GARP, which is present on the surface of stimulated Treg clones but not on Th clones. PMID: 19750484

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell surface.
  • 組織特異性：
    Preferentially expressed in regulatory T-cells (Tregs).
  • 數據庫鏈接：

    HGNC: 4161

    OMIM: 137207

    KEGG: hsa:2615

    STRING: 9606.ENSP00000260061

    UniGene: Hs.151641



主站蜘蛛池模板： 扒开双腿疯狂进出爽爽爽视频| 日本真人边吃奶边做爽免费视频| 欧美人与动性xxxxx交性| 亚洲熟女乱色一区二区三区| 国产成a人亚洲精品无码樱花| 日韩一卡二卡三卡四卡免费观在线| 中国国产1级毛卡片| 欧美噜噜久久久xxx| 日本乱妇乱子视频网站-百度| 欧美人与动牲交xxxxbbbb| 最新版天堂资源中文官网 | av边做边流奶水无码免费| 亚洲熟妇丰满多毛xxxx| 欧美日韩国产精品自在自线| 国产手机在线亚洲精品观看| 亚洲成av人影院无码不卡| 国产二级一片内射视频插放| 亚洲中文字幕无码av| 国产原创av中文在线观看| 夜夜夜夜猛噜噜噜噜噜| av无码精品一区二区三区宅噜噜| 忍着娇喘人妻被中出中文字幕| 精品熟女少妇av久久免费软件| 99精品众筹模特自拍视频 | 亚洲中字幕日产av片在线| 国产偷v国产偷v亚洲高清| 蜜桃视频网站| 国内无遮挡18禁无码网站免费| 亚洲性无码av在线dvd| 男女做爰真人视频直播| 国产揉捏爆乳巨胸挤奶视频| 亚洲 欧美 动漫 少妇 自拍| 色综亚洲国产vv在线观看| 国产成人精品高清在线观看99| 免费能直接看黄的视频| 亚洲线精品一区二区三区影音先锋 | 男人撕开奶罩揉吮奶头视频| 国产美女被遭高潮免费网站| 国产精品无码av一区二区三区| 给我免费的视频在线观看| 丰满多毛的陰户视频|