在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Transcription factor Spi-B (SPIB)

Recombinant Human Transcription factor Spi-B (SPIB)

  • 中文名稱：
    人SPIB重組蛋白
  • 貨號：
    CSB-YP022568HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SPIB重組蛋白
  • 貨號：
    CSB-EP022568HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SPIB重組蛋白
  • 貨號：
    CSB-EP022568HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SPIB重組蛋白
  • 貨號：
    CSB-BP022568HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SPIB重組蛋白
  • 貨號：
    CSB-MP022568HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SPIB
  • Uniprot No.：
  • 別名：
    SPI B; Spi B transcription factor; Spib; SPIB_HUMAN; Transcription factor Spi-B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-262
  • 氨基酸序列
    MLALEAAQLD GPHFSCLYPD GVFYDLDSCK HSSYPDSEGA PDSLWDWTVA PPVPATPYEA FDPAAAAFSH PQAAQLCYEP PTYSPAGNLE LAPSLEAPGP GLPAYPTENF ASQTLVPPAY APYPSPVLSE EEDLPLDSPA LEVSDSESDE ALVAGPEGKG SEAGTRKKLR LYQFLLGLLT RGDMRECVWW VEPGAGVFQF SSKHKELLAR RWGQQKGNRK RMTYQKLARA LRNYAKTGEI RKVKRKLTYQ FDSALLPAVR RA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation.
  • 基因功能參考文獻：
    1. Results provide evidence that SPIB is a specific transcription factor that participates in pH-mediated regulation of AQP1 gene expression. PMID: 29554889
    2. These results show that the mechanism of action of lenalidomide in ABC-DLBCL cells involves downregulation of SPIB transcription by cereblon-induced degradation of IKAROS. PMID: 28893618
    3. High SPIB expression is associated with Lung Cancer metastasis. PMID: 28754672
    4. our data indicate that SPIB expression is a clinically novel poor prognostic factor in DLBCL that contributes to treatment resistance, at least in part, through an anti-apoptotic mechanism. PMID: 27348272
    5. Findings establish a molecular hierarchy among POU2F2, SPIB and ID2 during B-cell differentiation, and suggest that aberrant expression of these transcription factors plays an important role in arresting plasmacytic differentiation in WM. PMID: 24801987
    6. The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model. PMID: 23439650
    7. Our data indicate that the CBFbeta-SMMHC's C-terminus is essential to induce embryonic hematopoietic defects and leukemogenesis. PMID: 23165482
    8. Fine mapping identified 26 single-nucleotide polymorphisms (SNPs) across the CLEC16A-SOCS1 and 11 SNPs across the SPIB locus with significant association to primary biliary cirrhosis. PMID: 22257840
    9. Data show that in a cereblon-dependent fashion, lenalidomide downregulates IRF4 and SPIB, transcription factors that together prevent IFNbeta production. PMID: 22698399
    10. The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1. PMID: 22510878
    11. The effect of mutating Spi-B-binding sites within the JC virus promoter/enhancer on early viral gene expression strongly suggests a role for Spi-B binding to the viral promoter/enhancer in the activation of early viral gene expression. PMID: 22071512
    12. These results suggest that Spi-B could regulate JC virus gene expression in susceptible cells, and may play an important role in JC virus activity in the immune and nervous systems. PMID: 20826618
    13. Spi-B is expressed in plasmacytoid dendritic cell precursors and inhibits T-, B-, and NK-cell development PMID: 12393575
    14. Spi-B is a key regulator of human pDC development. PMID: 15583020
    15. DL1-induced activation of the Notch1 pathway controls the lineage commitment of early thymic precursors by altering the levels between Spi-B and GATA-3. PMID: 16317090
    16. By chromatin immunoprecipitation and assays using an inducible Spi-B construct BLIMP1 and XBP-1 were identified as direct target genes of Spi-B mediated repression. PMID: 18552212
    17. findings suggest that the concurrent action of Spi-B and E2-2 controls the development of progenitor cells into the plasmacytoid dendritic cell lineage PMID: 18792017

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    ETS family
  • 組織特異性：
    Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver.
  • 數據庫鏈接：

    HGNC: 11242

    OMIM: 606802

    KEGG: hsa:6689

    STRING: 9606.ENSP00000471921

    UniGene: Hs.437905



主站蜘蛛池模板： 中文字幕高清免费日韩视频在线| 久久久久久综合岛国免费观看| 99精品国产一区二区三区不卡 | 在线播放无码后入内射少妇| 亚洲伊人丝袜精品久久| 欧美一性一乱一交一免费视频| 伊人久久精品无码av一区| 人妻互换免费中文字幕| 国产乡下三级全黄三级bd| 任我爽精品视频在线观看| 久久精品国产久精久精| 国产麻豆天美果冻无码视频| 俄罗斯大荫蒂女人毛茸茸| 国产日产亚洲系列最新美使用方法 | 男人添女人囗交做爰视频| 精品产区wnw2544| 成人亚欧欧美激情在线观看| 曰本女人牲交高潮视频| 色窝窝无码一区二区三区色欲| 国产亚洲成av片在线观看| 日本亚洲欧美在线视观看| 国产欧美亚洲日韩图片| 97精品人人a片免费看| 国产香蕉国产精品偷在线| 欧美成人精品午夜免费影视| 午夜福利伦伦电影理论片在线观看| 亚洲国产精品无码久久久久高潮| 国产高清不卡无码视频| 欧美日韩精品一区二区性色a+v | 被窝的午夜无码福利专区| 草的我好爽视频| 加勒比一本heyzo高清视频| 久久久久国色av免费看图片| 国产精品自在拍一区二区不卡| 日本va欧美va精品发布| 99热这里只就有精品22| 两个男人吮她的花蒂和奶水视频 | 亚洲自偷自偷偷色无码中文| 国产jk精品白丝av在线观看| 久在线精品视频线观看| 夜夜欢性恔真人免费视频|