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  4. Recombinant Human Torsin-2A (TOR2A)

Recombinant Human Torsin-2A (TOR2A)

  • 中文名稱：
    人TOR2A重組蛋白
  • 貨號：
    CSB-YP702498HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TOR2A重組蛋白
  • 貨號：
    CSB-EP702498HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TOR2A重組蛋白
  • 貨號：
    CSB-EP702498HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TOR2A重組蛋白
  • 貨號：
    CSB-BP702498HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TOR2A重組蛋白
  • 貨號：
    CSB-MP702498HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TOR2A
  • Uniprot No.：
  • 別名：
    TOR2A; TORP1; UNQ6408/PRO21181; Torsin-2A; Torsin family 2 member A; Torsin-related protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    27-321
  • 氨基酸序列
    AWDL ASLRCTLGAF CECDFRPDLP GLECDLAQHL AGQHLAKALV VKALKAFVRD PAPTKPLVLS LHGWTGTGKS YVSSLLAHYL FQGGLRSPRV HHFSPVLHFP HPSHIERYKK DLKSWVQGNL TACGRSLFLF DEMDKMPPGL MEVLRPFLGS SWVVYGTNYR KAIFIFISNT GGKQINQVAL EAWRSRRDRE EILLQELEPV ISRAVLDNPH HGFSNSGIME ERLLDAVVPF LPLQRHHVRH CVLNELAQLG LEPRDEVVQA VLDSTTFFPE DEQLFSSNGC KTVASRIAFF L
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. Increased expression of salusin-beta is associated with Diabetes Mellitus-Induced Endothelial Dysfunction. PMID: 29359008
    2. the effects of salusin-alpha on the expression of some pro- and anti-inflammatory cytokines and on TNF-alpha-induced inflammatory responses in human umbilical vein endothelial cells (HUVECs) were examined PMID: 29223158
    3. Salusin-beta mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway. PMID: 28647373
    4. Overexpression of salusin-beta is associated with ovarian cancer. PMID: 28184918
    5. Study provides evidence results that salusin-beta induces foam formation and monocyte adhesion via miR155/NOX2/NFkappaB-mediated ACAT-1 and VCAM-1 expressions in vascular smooth muscle cells. PMID: 27004848
    6. These results demonstrate contrasting actions of salusin-beta in the control of water intake via the central and peripheral systems and highlight it as a potent endogenous antidipsogenic neuropeptide. PMID: 26869388
    7. salusin-alpha might serve as a potential biomarker for predicting the development and progression of coronary artery disease. PMID: 23611255
    8. Plasma salusin-alpha and salusin-beta levels are increased in endometrioma patients and positively correlated with endometrioma size. PMID: 26008602
    9. Serum salusin-Beta levels were associated with the presence and severity of coronary artery disease. PMID: 25730454
    10. Salusin-beta but not saluin-alpha is able to promote inflammatory responses in human umbilical vein endothelial cells. PMID: 25210730
    11. circulating salusin-beta levels are suppressed following physiological parasympathetic stimulation and appear to constitute a negative feedback relationship with the parasympathetic nervous system PMID: 25063054
    12. the mechanism of salusins in atherosclerosis PMID: 24621517
    13. Salusin-beta is an antimicrobial peptide with potent antibacterial activity against Gram-positive microorganisms. PMID: 24881665
    14. The Salusin-alpha, salusin-beta are locally synthesized in the arteries and veins and might be important markers in the cardiopulmonary bypass. PMID: 22884920
    15. Human circulating salusin-beta, is a potent hemodynamics and atherogenesis regulator. PMID: 24098553
    16. Salusins, newly identified regulators of hemodynamics and mitogenesis, are increased within the serum of women with polycystic ovary syndrome. PMID: 22827297
    17. There was no positive relationship between serum salusin-alpha and salusin-beta levels and preeclampsia. PMID: 22533552
    18. Salusin-beta accelerates the development of atherosclerotic lesions in APOE knockout mice whilst salusin-alpha exerts anti-atherosclerotic effects. PMID: 20684826
    19. Our results suggest that the interaction of tyrosine hydroxylase and mutant torsinA may contribute to the phenotype and reported dopaminergic dysfunction in torsinA-mediated dystonia. PMID: 19761814
    20. the identification and characterization of two related peptides of 28 and 20 amino acids, which we designated salusin-alpha and salusin-beta. Salusins are translated from an alternatively spliced mRNA of TOR2A PMID: 12910263
    21. Human salusin beta is a surrogate ligand of mouse MrgA1. PMID: 16697365
    22. Decrease in serum salusin-alpha, an anti-atherogenic peptide, may be associated with carotid atherosclerosis in hypertensive patients. PMID: 18497465
    23. salusin-alpha is biosynthesized and released from human-derived cells. PMID: 18804130

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  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    ClpA/ClpB family, Torsin subfamily
  • 組織特異性：
    Isoform 1 is expressed ubiquitously, except in cardiac and endothelial tissues.
  • 數據庫鏈接：

    HGNC: 11996

    OMIM: 608052

    KEGG: hsa:27433

    UniGene: Hs.444106



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