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  4. Recombinant Human Tolloid-like protein 1 (TLL1), partial

Recombinant Human Tolloid-like protein 1 (TLL1), partial

  • 中文名稱：
    人TLL1重組蛋白
  • 貨號：
    CSB-YP023595HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TLL1重組蛋白
  • 貨號：
    CSB-EP023595HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TLL1重組蛋白
  • 貨號：
    CSB-EP023595HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TLL1重組蛋白
  • 貨號：
    CSB-BP023595HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TLL1重組蛋白
  • 貨號：
    CSB-MP023595HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TLL1
  • Uniprot No.：
  • 別名：
    ASD6; TLL; TLL1; TLL1_HUMAN; Tolloid like 1; Tolloid-like protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.
  • 基因功能參考文獻：
    1. Multivariate analysis showed rs17047200 AT/TT to be an independent risk factor for HCC (hazard ratio, 1.78; P = .008). PMID: 28163062
    2. This SNP [TLL1 gene ]could not be confirmed as a risk factor for CHD [coronary heart disease]in T2DM [type-2 Diabetes mellitus]patients PMID: 25233961
    3. This study identified TLL1 as a new susceptibility gene for PTSD. PMID: 23726511
    4. TLL-1 gene mutation with an insertion mutation of base A in exon 10 is common in Chinese patients with sporadic congenital heart diseases. PMID: 22883091
    5. We identified a variant in a single PPAR pathway gene, TLL1, that is associated with the extent of coronary artery disease independently of clinical predictors, specifically in patients with type 2 diabetes mellitus. PMID: 21911782
    6. Data demonstrate that TLL-1, which has intermediate activity, forms a calcium-ion dependent dimer with monomers stacked side-by-side. PMID: 20043912
    7. tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains PMID: 16507574
    8. The crystal structures of the protease domains of human BMP-1 and the closely related Tolloid-like protease 1 (TLL-1), are reported. PMID: 18824173
    9. Mutations in mammalian tolloid-like 1 gene detected in adult patients with Atrial septal defect PMID: 18830233
    10. These results indicate that the hypoxia responsive motif is directly involved in the activation of the mTll-1 transcription under hypoxic conditions. PMID: 19723501

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  • 相關疾病：
    Atrial septal defect 6 (ASD6)
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase M12A family
  • 數據庫鏈接：

    HGNC: 11843

    OMIM: 606742

    KEGG: hsa:7092

    STRING: 9606.ENSP00000061240

    UniGene: Hs.106513



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