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  4. Recombinant Human Thyroid receptor-interacting protein 11 (TRIP11), partial

Recombinant Human Thyroid receptor-interacting protein 11 (TRIP11), partial

  • 中文名稱：
    人TRIP11重組蛋白
  • 貨號：
    CSB-YP620888HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TRIP11重組蛋白
  • 貨號：
    CSB-EP620888HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TRIP11重組蛋白
  • 貨號：
    CSB-EP620888HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TRIP11重組蛋白
  • 貨號：
    CSB-BP620888HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TRIP11重組蛋白
  • 貨號：
    CSB-MP620888HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TRIP11
  • Uniprot No.：
  • 別名：
    TRIP11; CEV14; Thyroid receptor-interacting protein 11; TR-interacting protein 11; TRIP-11; Clonal evolution-related gene on chromosome 14 protein; Golgi-associated microtubule-binding protein 210; GMAP-210; Trip230
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function. It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex. Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription.
  • 基因功能參考文獻(xiàn)：
    1. Decreased expressions of TRIP11, THRA, and THRB correlated with poor survival of renal cell cancer patients. Expressions of TRIP11 and HIF-1beta correlated with tumor grades. PMID: 29022645
    2. The authors conclude that the Golgi uses GMAP-210 as a filter to select transport vesicles according to their size and bulk lipid composition. PMID: 27458799
    3. role for GMAP-210 in several trafficking steps at the ER-Golgi interface PMID: 25717001
    4. GMAP-210 has a role for membrane tethering in maintaining Golgi structure and a role for Rab2 binding in linking tethering with downstream docking and fusion events at the Golgi apparatus. PMID: 25473115
    5. Rb is present in HIF1alpha-ARNT/HIF1beta transcriptional complexes associated with TRIP230 as determined by co-immuno-precipitation, GST-pull-down and ChIP assays PMID: 24919196
    6. identification of a mutation affecting GMAP-210 in mice, and then in humans, as the cause of a lethal skeletal dysplasia PMID: 20089971
    7. The overexpression of this protein blocks anterograde and retrograde transport between the endoplasmic reticulum and the Golgi apparatus. PMID: 12383348
    8. demonstrate that the thyroid hormone receptor/retinoblastoma-interacting protein 230 (TRIP230) interacts directly with aryl hydrocarbon receptor nuclear translocator(ARNT) and is essential for both hypoxic and TCDD-mediated transcriptional responses PMID: 15485806
    9. the attachment of golgin GMAP-210 to lipid membranes PMID: 18451304
    10. Localisation of GMAP-210 (TRIP11) to Golgi is the result of the combined action of two domains (N- and C-terminal) that recognize different sub-regions of the Golgi apparatus. PMID: 19715559

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  • 相關(guān)疾病：
    Achondrogenesis 1A (ACG1A)
  • 亞細(xì)胞定位：
    Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Endoplasmic reticulum-Golgi intermediate compartment membrane. Note=Associates with the ends of centrosome-nucleated microtubules.
  • 組織特異性：
    Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung. Isoform 1 and isoform 2 are expressed in art
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12305

    OMIM: 200600

    KEGG: hsa:9321

    STRING: 9606.ENSP00000267622

    UniGene: Hs.632339



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