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  4. Recombinant Human Thioredoxin-related transmembrane protein 1 (TMX1), partial

Recombinant Human Thioredoxin-related transmembrane protein 1 (TMX1), partial

  • 中文名稱：
    人TMX1重組蛋白
  • 貨號：
    CSB-YP023950HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TMX1重組蛋白
  • 貨號：
    CSB-EP023950HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TMX1重組蛋白
  • 貨號：
    CSB-EP023950HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TMX1重組蛋白
  • 貨號：
    CSB-BP023950HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TMX1重組蛋白
  • 貨號：
    CSB-MP023950HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TMX1
  • Uniprot No.：
  • 別名：
    PDIA11; Protein disulfide isomerase family A, member 11; Thioredoxin domain containing 1; Thioredoxin domain containing; Thioredoxin domain-containing protein 1; Thioredoxin-related transmembrane protein 1; TMX; TMX1; TMX1_HUMAN; Transmembrane Trx-related protein; TXNDC; TXNDC1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
  • 基因功能參考文獻：
    1. TMX1 selectively intervenes in clearance of membrane-tethered Endoplasmic Reticulum-Associated Degradation substrates. TMX1 preferentially acts on membrane-tethered folding-defective polypeptides essentially ignoring the same misfolded ectodomains, when not associated to the Endoplasmic Reticulum membrane. PMID: 29932915
    2. TMX1 increases mitochondrial ATP production and apoptosis progression. PMID: 27502484
    3. Here we show that TMX1, one of the few transmembrane members of the family, forms functional complexes with the ER lectin calnexin and preferentially intervenes during maturation of cysteine-containing, membrane-associated proteins PMID: 26246604
    4. We conclude that TMX plays a major role in host defense under the type of inflammatory conditions associated with oxidative stress. PMID: 22924822
    5. the silencing of TMX in the prostatic cell line DU145 reduced the sensitivity of the cells to ricin intoxication further confirming a role for this enzyme in intracellular ricin activation. PMID: 22228764
    6. TMX1 is enriched on the mitochondria-associated membrane. Targeting TMX to the MAM requires palmitoylation of two membrane-proximal cytosolic cysteines. PMID: 22045338
    7. These results suggest a specific role for transmembrane thioredoxin-related protein TMX and its mechanism of action in redox-based ER quality control. PMID: 19741092

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Ubiquitous. Highly expressed in kidney, liver, placenta and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15487

    OMIM: 610527

    KEGG: hsa:81542

    STRING: 9606.ENSP00000393316

    UniGene: Hs.125221



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