在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Tau-tubulin kinase 1 (TTBK1), partial

Recombinant Human Tau-tubulin kinase 1 (TTBK1), partial

  • 中文名稱：
    人TTBK1重組蛋白
  • 貨號：
    CSB-YP732936HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TTBK1重組蛋白
  • 貨號：
    CSB-EP732936HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TTBK1重組蛋白
  • 貨號：
    CSB-EP732936HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TTBK1重組蛋白
  • 貨號：
    CSB-BP732936HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TTBK1重組蛋白
  • 貨號：
    CSB-MP732936HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TTBK1
  • Uniprot No.：
  • 別名：
    BDTK; Brain derived tau kinase; Brain-derived tau kinase; KIAA1855; Tau tubulin kinase 1; Tau-tubulin kinase 1; TTBK1; TTBK1_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
  • 基因功能參考文獻(xiàn)：
    1. Our findings suggest a possible etiology for the two most common frontotemporal lobar degeneration subtypes through a TTBK1/2 activation driven mechanism of neurodegeneration PMID: 29409526
    2. TTBK1/2 kinases may represent attractive targets for therapeutic intervention for TDP-43 proteinopathies such as Amyotrophic lateral sclerosis and Frontotemporal lobar degeneration-TDP. PMID: 25473830
    3. X-ray diffraction data were collected and the structure of TTBK1 was determined by molecular replacement both as an apo structure and in complex with a kinase inhibitor PMID: 24637750
    4. The study suggested that a role for TTBK1 in pre-tangle formation prior to the formation of fibrillar tau and strengthen the idea that tau is phosphorylated at Ser422 at an early/intermediate stage in NFT formation. PMID: 23088643
    5. TTBK1 may play an important role in the pathogenesis of sporadic late-onset Alzheimer's disease in a Han Chinese population. PMID: 21219968
    6. This study demonistrated that TTBK1 is a promising new candidate tau phosphorylation-related gene for Alzheimer's disease risk. PMID: 20096481
    7. TTBK1 in AD brain may be one of the underlying mechanisms inducing CDK5 and calpain activation, NR2B downregulation, and subsequent memory dysfunction. PMID: 19118186

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CK1 Ser/Thr protein kinase family
  • 組織特異性：
    Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscl
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19140

    KEGG: hsa:84630

    STRING: 9606.ENSP00000259750

    UniGene: Hs.485436



主站蜘蛛池模板： www亚洲精品少妇裸乳一区二区| 亚洲国产av无码一区二区三区| 亚洲图片校园另激情类小说| 亚洲第一无码av无码专区| 中文无码天天av天天爽| 国产美女极度色诱视频www| 亚洲这里只有久热精品伊人| 麻豆丰满少妇chinese| 亚洲精品无码中文久久字幕| 性欧美老妇另类xxxx| 女邻居丰满的奶水| 国产高清在线精品一本大道| 午夜成人亚洲理论片在线观看| 亚洲成av人最新无码| 在线永久免费观看黄网站| 久久精品2021国产| 成人无码av网站在线观看| 69综合精品国产二区无码| 亚欧洲乱码视频一二三区| 99re6热视频这里只精品首页| 最新69成人精品视频免费| 国产av一区二区精品久久| 麻花传媒在线观看免费| 国语国产精精品国产国语清晰对话| 漂亮人妻熟睡中被公侵犯中文版| 国产精品嫩草99av在线| 手机在线看永久av片免费| 无码精品一区二区三区在线| 国产成人a区在线观看| 国产欧美丝袜在线二区| av鲁丝一区鲁丝二区鲁丝三区| 久久成人麻豆午夜电影| 中文人妻av久久人妻水密桃| 亚洲国产品综合人成综合网站| 东北女人啪啪对白| 老鸭窝视频在线观看| 中国肥老太婆高清video| 中文午夜人妻无码看片| 免费观看黄网站在线播放| 亚洲国产成人久久一区二区三区| 亚洲精品久久久久久久久久久捆绑 |