在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (TAB3)

Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (TAB3)

  • 中文名稱：
    人TAB3重組蛋白
  • 貨號：
    CSB-YP850806HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TAB3重組蛋白
  • 貨號：
    CSB-EP850806HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TAB3重組蛋白
  • 貨號：
    CSB-EP850806HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TAB3重組蛋白
  • 貨號：
    CSB-BP850806HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TAB3重組蛋白
  • 貨號：
    CSB-MP850806HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    MAP3K7IP 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NAP1 ; NF-kappa-B-activating protein 1; NFkB activating protein 1; TAB-3; Tab3; TAB3_HUMAN; TAK1 binding protein 3; TAK1-binding protein 3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; TGF-beta-activated kinase 1-binding protein 3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-712
  • 氨基酸序列
    AQSSPQLDI QVLHDLRQRF PEIPEGVVSQ CMLQNNNNLE ACCRALSQES SKYLYMEYHS PDDNRMNRNR LLHINLGIHS PSSYHPGDGA QLNGGRTLVH SSSDGHIDPQ HAAGKQLICL VQEPHSAPAV VAATPNYNPF FMNEQNRSAA TPPSQPPQQP SSMQTGMNPS AMQGPSPPPP PPSYMHIPRY STNPITVTVS QNLPSGQTVP RALQILPQIP SNLYGSPGSI YIRQTSQSSS GRQTPQSTPW QSSPQGPVPH YSQRPLPVYP HQQNYQPSQY SPKQQQIPQS AYHSPPPSQC PSPFSSPQHQ VQPSQLGHIF MPPSPSTTPP HPYQQGPPSY QKQGSHSVAY LPYTASSLSK GSMKKIEITV EPSQRPGTAI NRSPSPISNQ PSPWNQHSLY TATTPPSSSP SRGISSQPKP PFSVNPVYIT YTQPTGPSCT PSPSPRVIPN PTTVFKITVG RATTENLLNL VDQEERSAAP EPIQPISVIP GSGGEKGSHK YQRSSSSGSD DYAYTQALLL HQRARMERLA KQLKLEKEEL ERLKSEVNGM EHDLMQRRLR RVSCTTAIPT PEEMTRLRSM NRQLQINVDC TLKEVDLLQS RGNFDPKAMN NFYDNIEPGP VVPPKPSKKD SSDPCTIERK ARRISVTSKV QADIHDTQAA AADEHRTGST QSPRTQPRDE DYEGAPWNCD SCTFLNHPAL NRCEQCEMPR YT
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.; May be an oncogenic factor.
  • 基因功能參考文獻：
    1. these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of Esophageal squamous cell carcinoma. PMID: 30226617
    2. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 signaling as a novel pathogenic substrate for polyvalvular syndrome. PMID: 27452334
    3. Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in triple negative breast cancer metastasis. PMID: 27009840
    4. Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells. PMID: 26476534
    5. TAB3 regulated ovarian cancer cell bioactivity and chemotherapy performance via the NF-kappaB pathway. PMID: 27651027
    6. Upregulation of miR-532-5p and subsequent suppression of the SESTD1 and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection. PMID: 26676784
    7. miR-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE PMID: 26555189
    8. miR-26b suppresses NF-kappaB signaling and sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis by inhibiting the expression of TAK1 and TAB3. PMID: 24565101
    9. conclude that TRIM38 negatively regulates TNFalpha- and IL-1beta-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha- and IL-1beta-induced signaling pathways PMID: 24434549
    10. Studies show that three proteins expressed in HEK-293T cells (NAP1, TANK and TBKBP1) interact with TBK1. PMID: 23286385
    11. MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha. PMID: 22660635
    12. human TAB2 and TAB3, ubiquitin-chain sensory proteins involved in NF-kappaB signalling, are directly inactivated by enteropathogenic Escherichia coli NleE, a conserved bacterial type-III-secreted effector responsible for blocking host NF-kappaB signalling PMID: 22158122
    13. These results point to the existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with TAK1. PMID: 22081109
    14. TAB3 is involved in IL-1-induced NF-kappaB activation by physically linking TAK1 to TRAF6. PMID: 14633987
    15. Identification of TAB3 as a binding partner of the protein kinase TAK1. PMID: 14670075
    16. TAB3 transforming growth factor is a constituent of the NF-kappaB pathway functioning upstream of tumor necrosis factor alpha-associated factor 6/transforming growth factor beta-activated kinase PMID: 14766965
    17. Data show that TAB2 and TAB3 are receptors that bind preferentially to polyubiquitin chains through a highly conserved zinc finger (ZnF) domain, and activate NF-kappa B and IKK. PMID: 15327770
    18. The TAB2/TAB3 interaction with TAK1 is crucial for the activation of signaling cascades mediated by interleukin-1, tumor necrosis factor, and receptor activator of nuclear factor-kappa B ligand (RANKL). PMID: 17158449

    顯示更多

    收起更多

  • 組織特異性：
    Widely expressed. Constitutively overexpressed in certain tumor tissues.; [Isoform 1]: Major transcript.; [Isoform 2]: Minor transcript.
  • 數據庫鏈接：

    HGNC: 30681

    OMIM: 300480

    KEGG: hsa:257397

    STRING: 9606.ENSP00000288422

    UniGene: Hs.188256



主站蜘蛛池模板： 97精品国自产在线偷拍| 国产无遮挡a片又黄又爽漫画| 成人无码www在线看免费 | 人人人妻人人澡人人爽欧美一区| 国产成人愉拍免费视频| 中文字幕av久久激情亚洲精品| 131美女爱做视频| 亚洲狠狠婷婷综合久久久久图片 | 欧美成人精精品一区二区| 久爱www成人网免费视频| 免费天堂无码人妻成人av电影| 午夜成人影院网站18进| 欧美亚洲日韩国产综合电影| 先锋影音最新色资源站| 久久久中日ab精品综合 | 亚洲色欲久久久久综合网| 中国亚洲女人69内射少妇| 噜噜高清欧美内射短视频| 婷婷伊人久久大香线蕉av| 日日做夜狠狠爱欧美黑人| 色护士极品影院| 国产无遮挡又黄又爽在线观看| 久久人人97超碰超国产| 日本免费一区二区三区日本| 欧美精品18videosex性欧美| 久久久久无码精品国产不卡| 老色69久久九九精品高潮| 亚洲色www成人永久网址| 亚洲色欲色欲www在线看| 黑人与中国少妇xxxx视频| 国产精品国产亚洲区艳妇糸列短篇| 天堂а√中文最新版地址在线| 中国熟妇内谢69xxxxx| 婷婷色综合视频在线观看 | 天天爱天天做狠狠久久做| 日本三级带日本三级带黄| 国内高清a自拍视频| 亚洲精品国产精品国产自2022| 国产精品无码无需播放器| 无码粉嫩虎白一线天在线观看 | 99精品视频一区在线观看|