在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Steroid hormone receptor ERR1 (ESRRA)

  • 中文名稱:
    Recombinant Human Steroid hormone receptor ERR1 (ESRRA)
  • 貨號:
    CSB-EP007834HUa0
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    51.5 kDa
  • 表達區域:
    1-423aa
  • 氨基酸序列
    MSSQVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGEQGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAVAGGPRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
  • 基因功能參考文獻:
    1. The present data indicated that ERRa acted as an oncogene in colon cancer cells, and the combined targeting of ERRa and MEK might be a promising therapeutic strategy for colon cancer treatment PMID: 30185207
    2. This work reveals a molecular mechanism by which ERRalpha-induced metabolic reprogramming promotes survival of lapatinib-resistant cancer cells. PMID: 27402251
    3. data showed that activation of NF-kappaB/IL-6 is involved in ERRalpha induced migration and invasion of non-small cell lung cancer cells; it suggested that ERRalpha might be a potential target for non-small cell lung cancer treatment PMID: 29862528
    4. Results show that ERRA is an interacting partner of PGC1a in a subset of human melanoma cells. Also, ERRA promotes mitochondrial oxidative metabolism in melanoma cells. PMID: 28596418
    5. LSD1 and ERRalpha coregulate several target genes involved in cell migration, including the MMP1 matrix metallo-protease, also activated through H3K9 demethylation at the transcriptional start site. PMID: 28348226
    6. TGF-beta treatment can trigger the epithelial-mesenchymal transition of osteosarcoma cells via ERRalpha/Snail pathways. PMID: 27532429
    7. LC3B and ESRRA might be a useful prognostic factor in patients with muscle-invasive bladder cancer. The co-expression of LC3B and ESRRA might be a prognostic and therapeutic target for patients with bladder cancer. PMID: 29599373
    8. These findings indicate that ERRalpha may serve as a novel molecular target for the treatment of endometrial cancer PMID: 27153547
    9. Gls is a novel ERRalpha target gene. PMID: 27501743
    10. can trigger the proliferation and migration of colorectal cancer cells via up regulation of IL-8 PMID: 28993941
    11. curcumin suppressed the ERRalpha gene expression through upregulation of miR-125a. Data from this study revealed a novel mechanism for curcumin-mediated apoptotic cell death, which involves tumor cell killing via activating miR-125a/ERRalpha pathway. PMID: 27231954
    12. blocking the ERRalpha-controlled mitochondrial program largely inhibits the PLA2R1-induced tumor-suppressive response. Together, our data document ERRalpha and its mitochondrial program as downstream effectors of the PLA2R1-JAK2 pathway leading to oncosuppression. PMID: 27041564
    13. results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRalpha expression, resulting in increased cell invasion capacities. PMID: 27227989
    14. HO-1-derived CO enhances mitochondrial biogenesis in astrocytes by activating L-type Ca(2+) channel-mediated PGC-1alpha/ERRalpha axis, leading to maintenance of astrocyte function and neuroprotection/recovery against damage of brain function PMID: 27639646
    15. in ERalpha negative breast cancer, the low level of ERalpha reduced miR-497 expression, which promoted ERRalpha expression that enhanced cell proliferation, migration, and invasion by increasing MIF expression and MMP9 activity. PMID: 27456360
    16. these data show that ERRalpha expression predicts response to tamoxifen treatment, and ERRalpha could be a biomarker of tamoxifen sensitivity and a prognostic factor in TNBC. PMID: 26542058
    17. ERRalpha suppression inhibits angiogenesis in HUVECs PMID: 26586335
    18. Incomplete autophagy and cell death by a necrotic processes, as a consequence of the cell energy failure, induced by pharmacological reduction of ERRalpha in adrenocortical carcinoma cells. PMID: 26312764
    19. CD68(+)CD163(+) macrophages secreted cytokines, such as IL17A, that upregulated ERalpha expression. PMID: 26744532
    20. Inhibition of ERRalpha suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin. PMID: 26160845
    21. mediates metabolic transition, which is required for induced pluripotency PMID: 25865501
    22. An ERRalpha 23-repeats polymorphisms with BMD in postmenopausal Egyptian women. PMID: 25903400
    23. Over-expression of ESRRA due to its gene amplification in OSCC PMID: 26639757
    24. targeting of ERRalpha and pathways regulating transcriptional HIF-2alpha are promising therapeutic avenues in neuroblastoma PMID: 25912138
    25. ERRalpha promoted the migration and invasion of A549 cells by inducing EMT, and Slug was involved in the process. Targeting ERRalpha might be an efficient approach for lung cancer treatment. PMID: 25480584
    26. control exerted by ERRalpha on RHOA stability is required for directional migration PMID: 25288732
    27. These results suggest ERRalpha activation as a mechanism of tumor aggressiveness and imply that targeting ERRa may be a promising approach in ovarian cancer treatment. PMID: 24419103
    28. this study demonstrated that ERR alpha plays an important role in the development of MTX resistance through blocking MTX-induced ROS production and attenuating the activation of p53 mediated apoptosis signaling pathway PMID: 24967384
    29. Estrogen receptor alpha coupled to the Bmi1 regulation pathway plays an important role in breast cancer progression. PMID: 24559156
    30. miR-125a post-transcriptionally regulates ESRRA in oral squamous cell carcinoma PMID: 25266720
    31. The frequency of the ESRRA/C11orf20 gene fusion in serous ovarian carcinomas of stages III and IV must be very low. PMID: 24504521
    32. Cell cycle dependent oscillatory expression of estrogen receptor-alpha links Pol II elongation to neoplastic transformation. PMID: 24979764
    33. ERRalpha is downregulated in uterosacral ligaments in pelvic organ prolapse PMID: 23700042
    34. ERRalpha can promote the hypoxic growth adaptation of prostate cancer cells via a protective interaction with HIF-1alpha, suggesting ERRalpha as a potential therapeutic target for cancer treatment. PMID: 24425001
    35. Data indicate that a stable cell clones have an intact peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha)/estrogen-related receptor alpha (ERRalpha) axis can be used to detect environmental chemicals that act on the signaling pathway. PMID: 24457025
    36. There are 3 ERRalpha response elements (ERR response element, ERRE) in the osteocalcin promoter, and ERRalpha interacted cooperatively with PGC-1alpha could improve the osteocalcin promoter activity. PMID: 23788330
    37. analysis of twenty members across three generations identified a rare missense mutation in the estrogen-related receptor alpha (ESRRA) gene that segregated with eating disorders PMID: 24216484
    38. ERRalpha coordinates colon cancer cell proliferation and tumorigenic capacity with energy metabolism. PMID: 23720198
    39. analysis of clinical datasets from liver tissues showed a negative correlation between expressions of ERRalpha and PTEN in patients with liver cancer. PMID: 23836899
    40. the expression of ERRalpha mRNA was significantly increased during the late stage of osteogenic differentiation of human periodontal ligament tissue-derived mesenchymal stem cells. PMID: 23525223
    41. ERRa and OPN are co-expressed and higher in colorectal cancer cells as opposed to normal mucosa. Data provide compelling evidence that OPN is a direct target of ERRa, the induction of which could clearly contribute to colorectal cancer pathogenesis. PMID: 23680656
    42. ERRalpha can act as a transcriptional activator of Runx2-I in presence of peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1alpha). PMID: 23403054
    43. the role played by ERRalpha in the regulation of lactate dehydrogenases A and B PMID: 23516535
    44. A possible role of ERRalpha in adrenal development and adrenocortical carcinoma. PMID: 23123734
    45. ERRalpha and PGC-1beta are key players in the etiology of breast cancer by coordinating the transcriptional regulation of genes located in the 17q12 region, a process that also involves interference with the repressive function of ERalpha on ERBB2 expression. PMID: 20961995
    46. Data identify ERRalpha as a new regulator of the Wnt-signaling pathway during osteoblast differentiation, through a cell-intrinsic mechanism not affecting beta-catenin nuclear translocation. PMID: 22333182
    47. ERRalpha-induced adipogenesis is triggered by modulating the expression of PGC-1beta. PMID: 21732060
    48. Data observed in DMD and aging skeletal muscle enrichment in motifs for candidate transcription factors that may coordinate either the immune/fibrosis responses (ETS1, IRF1, NF1) or the mitochondrial metabolism (ESRRA). PMID: 22096509
    49. these data suggest that RaRF sequesters ERRalpha in the nucleolus through a specific interaction, thereby inhibiting its transcriptional activity. PMID: 22266318
    50. Exposure to XCT790, a synthetic inverse agonist of the orphan nuclear oestrogen-related receptor alpha (ERRalpha), also induced EGFR and HB-EGF expression to the same extent as AM251. PMID: 21449913

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Nuclear hormone receptor family, NR3 subfamily
  • 數據庫鏈接:

    HGNC: 3471

    OMIM: 601998

    KEGG: hsa:2101

    STRING: 9606.ENSP00000000442

    UniGene: Hs.110849



主站蜘蛛池模板: 亚洲中文久久精品无码1| 夜夜躁狠狠躁日日躁202| 天天躁夜夜躁天干天干2020| 国产成人青青久久大片| 国产成人精品综合久久久| 欧美精品乱码99久久蜜桃| 一区二区视频传媒有限公司| 日韩亚洲国产中文永久| 小荡货好紧好爽奶头大视频 | av无码天堂一区二区三区| 高清国产av一区二区三区| 性一交一乱一伦一色一情孩交| 国产麻豆9l精品三级站| 午夜精品久久久久久久四虎| 亚洲人成网站18禁止中文字幕| 熟妇人妻一区二区三区四区 | 5个黑人躁我一个视频| 久久综合给合久久狠狠狠97色69 | 国产福利视频| 综合无码成人aⅴ视频在线观看| 大香网伊人久久综合网2018| 欧美性猛交ⅹxxx乱大交妖精| 国内揄拍国产精品人妻门事件 | 日本成本人三级在线观看| 欧美肥老太交性506070| 日韩精品一区二区在线观看| 亚洲综合色在线视频www| 中老年熟妇激情啪啪大屁股| 欧美日韩在线视频一区| 久久777国产线看观看精品 | 成人性生交大片免费看小说| 亚洲中文字幕无码av正片| 国产香蕉尹人在线观看视频| 久久成人影院精品777| 国产精品综合一区二区三区| 国产美女精品视频线播放| 国产精品爽爽久久久久久| 天天狠天天透天干天干| 国产日韩av一区二区三区五区| 人妻饥渴偷公乱中文字幕| 特级无码毛片免费视频播放▽|