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  4. Recombinant Human Sterile alpha motif domain-containing protein 9 (SAMD9), partial

Recombinant Human Sterile alpha motif domain-containing protein 9 (SAMD9), partial

  • 中文名稱：
    人SAMD9重組蛋白
  • 貨號：
    CSB-YP705524HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SAMD9重組蛋白
  • 貨號：
    CSB-EP705524HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SAMD9重組蛋白
  • 貨號：
    CSB-EP705524HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SAMD9重組蛋白
  • 貨號：
    CSB-BP705524HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SAMD9重組蛋白
  • 貨號：
    CSB-MP705524HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SAMD9
  • Uniprot No.：
  • 別名：
    C7orf5; DRIF1; expressed in aggressive fibromatosis; KIAA2004; NFTC; OEF1; OEF2; SAM domain-containing protein 9; SAMD9; SAMD9_HUMAN; sterile alpha motif domain containing 9; Sterile alpha motif domain-containing protein 9
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion.
  • 基因功能參考文獻：
    1. In humans, both SAMD9 and SAMD9L are poxvirus restriction factors, although the latter requires interferon induction in many cell types. PMID: 29447249
    2. findings establish SAMD9/SAMD9L mutations as a new class of germline lesions with variable clinical phenotypes, including familial MDS PMID: 28487541
    3. Progressive loss of mutated SAMD9 through the development of monosomy 7 (-7), deletions of 7q (7q-), and secondary somatic loss-of-function (nonsense and frameshift) mutations in SAMD9 rescued the growth-restricting effects of mutant SAMD9 proteins in bone marrow and was associated with increased length of survival. PMID: 28346228
    4. SAMD9 mutation is associated with MIRAGE syndrome. PMID: 27182967
    5. Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to SAMD9 or WDR6. PMID: 26242627
    6. SAMD9 is down-regulated in non-small cell lung cancer. Knockdown of SAMD9 expression increased the invasion, migration and proliferation in H1299 cells in vitro and overexpression of SAMD9 suppressed proliferation and invasion in A549 cells. PMID: 25450373
    7. When SAMD9 is stimulated due to failure of the viral antagonism during infection, the resulting antiviral granules exhibit properties different from those of the canonical stress granules. PMID: 25428864
    8. Over-expression of SAMD9 is correlated with the metastasis of esophageal squamous cell carcinoma PMID: 24721411
    9. M062 also binds and antagonizes cellular SAMD9 in human cells, suggesting that SAMD9 is a novel innate antiviral factor against poxviruses. PMID: 21248034
    10. SAMD9, an IFN-gamma-responsive protein, interacts with RGL2 to diminish the expression of EGR1, a protein of direct relevance to the pathogenesis of ectopic calcification and inflammation. PMID: 21160498
    11. SAMD9 could be a key molecule to control cancer cell death by inactivated Sendai virus particle or IFN-beta treatment. PMID: 19830690
    12. Mutation analysis revealed a homozygous mutation in the SAMD9 gene (K1495E), which was found to segregate with the disease in all families and to interfere with the protein expression. PMID: 16960814
    13. SAMD9 and SAMD9L are a novel family of genes, which play a role regulating cell proliferation and suppressing the neoplastic phenotype; the human gene exists in rat, but is lost in mouse, due to a mouse specific rearrangement PMID: 17407603
    14. PIvotal role in calcification and thus implicated in various hereditary diseases such as atherosclerosis, calcinosis and autoimmune diseases. PMID: 17507861
    15. SAMD9 may have a role in the TNF-alpha signaling pathway and in the regulation of extra-osseous calcification PMID: 18094730

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  • 相關疾病：
    Tumoral calcinosis, normophosphatemic, familial (NFTC); MIRAGE syndrome (MIRAGE)
  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Widely expressed. Very low levels are detected in skeletal muscle. Not detected in brain. Down-regulated in aggressive fibromatosis, as well as in breast and colon cancers. Up-regulated in fibroblasts from patients with normophosphatemic tumoral calcinosi
  • 數據庫鏈接：

    HGNC: 1348

    OMIM: 610455

    KEGG: hsa:54809

    STRING: 9606.ENSP00000369292

    UniGene: Hs.65641



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