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  4. Recombinant Human Stabilin-2 (STAB2), partial

Recombinant Human Stabilin-2 (STAB2), partial

  • 中文名稱：
    人STAB2重組蛋白
  • 貨號：
    CSB-YP851979HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人STAB2重組蛋白
  • 貨號：
    CSB-EP851979HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人STAB2重組蛋白
  • 貨號：
    CSB-EP851979HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人STAB2重組蛋白
  • 貨號：
    CSB-BP851979HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人STAB2重組蛋白
  • 貨號：
    CSB-MP851979HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    STAB2
  • Uniprot No.：
  • 別名：
    190 kDa form stabilin-2; 190 kDa hyaluronan receptor for endocytosis; EGF-like; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; Fasciclin; FEEL-2; FEEL2; FELL; FEX2; HARE; Hyaluronan receptor for endocytosis; laminin-type EGF-like and link domain-containing scavenger receptor 2; link domain-containing scavenger receptor 2; STAB-2; Stab2; STAB2_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS.
  • 基因功能參考文獻：
    1. Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor. PMID: 29589907
    2. Data show that the hyaluronan receptor for endocytosis (HARE) NPLY2519 motif is necessary for both extracellular signal-regulated kinases ERK1/2 and NF-kappa B (NF-kappaB)signaling and that Tyr2519 is critical for these functions. PMID: 27100626
    3. Stabilin-2 can play a critical role in the first entrapping step of LN metastasis through homotypic interaction with the lymphatic endothelium and appears to be a tumor biomarker predicting for LN metastasis in patients with solid tumors PMID: 27919991
    4. HARE/Stabilin-2 splice variants are expressed in bone marrow, lymph node, and spleen PMID: 25446080
    5. a Link domain complex N-glycan is required specifically for HARE.hyaluronic acid-mediated activation of ERK1/2 and NF-kappaB-mediated gene expression PMID: 24942734
    6. Loss of Stabilin-2 expression in peri-tumourous transdifferentiated liver endothelial cells correlates with increased survival by preventing endothelial-tumour cell adhesive interactions and microvascular invasion. PMID: 23870052
    7. HARE may be part of a systemic tissue-stress sensor feedback system that responds to abnormal tissue turnover or damage as a danger signal PMID: 24247245
    8. stabilin-2 acts as a receptor for necrotic cell clearance. PMID: 23416077
    9. Hyaluronan binding to HARE mediates NF-kappaB-activated gene expression in a dose-dependent manner. PMID: 23530033
    10. knockdown of endogenous alphavbeta5 expression or treatment with a function-blocking alphavbeta5 antibody significantly decreased stabilin-2-mediated phagocytosis in the absence of soluble factors PMID: 22566688
    11. Ligament Flavum (LF) hypertrophy is accompanied by increased CD44 and CD44v5 expression. CD44v6 expression is not enhanced in LF hypertrophy. PMID: 22052472
    12. The results indicate that Link domain N-glycans stabilize interactions that facilitate HA binding to HARE. PMID: 20466649
    13. code for homologous transmembrane proteins featuring seven fasciclin-like adhesion domains, 18-20 epidermal-growth-factor domains, one X-link domain and three to six B-(X(7))-B hyaluronan-binding motifs PMID: 11829752
    14. amino acid sequence of 190-kDa protein composed of 1416 amino acids and alignment with rat sequence PMID: 12626425
    15. HARE has a role in endocytosis and species-specific glycosaminoglycan affinity PMID: 15208308
    16. A majority of HARE isoform is intracellular, within the endocytic system, suggesting transient surface residency typical of an active endocytic recycling receptor. PMID: 17145755
    17. study provides evidence that stabilin-2 is a novel phosphatidylserine receptor, which performs a key function in the rapid clearance of cell corpses PMID: 17962816
    18. GULP is a likely downstream molecule in the stabilin-2-mediated signaling pathway and plays an important role in stabilin-2-mediated phagocytosis PMID: 18230608
    19. when HARE binds HA, that leads to activation of ERK1/2, important mediators of intracellular signal transduction. PMID: 18387958
    20. HARE in the sinusoidal endothelial cells of lymph nodes and liver likely mediates the efficient systemic clearance of Hep and many different Hep-binding protein complexes from the lymphatic and vascular c PMID: 18434317
    21. HARE binds to hyaluronan and heparin simultaneously PMID: 18499864
    22. Thymosin beta4 is a downstream molecule of stabilin-2 that plays a role in stabilin-2-mediated cell corpse clearance. PMID: 18519035
    23. although NPLY may be the most important motif, it functions together with two other endocytic motifs; thus three signal sequences (YSYFRI, FQHF, and NPLY) provide redundancy to mediate coated pit targeting and endocytosis of HARE PMID: 18539600
    24. Epidermal growth factor (EGF)-like domain repeats (EGFrp) in stabilin-2 can directly and specifically recognize phosphatidylserine. PMID: 18573870
    25. Both unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) are cleared by HARE/Stab2. The differences in the affinities of HARE binding to LMWH and UFH likely explain the longer in vivo circulating half-life of LMWH compared with UFH. PMID: 19359419

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Only a small amount appears to be present at the cell surface (PubMed:17145755).
  • 組織特異性：
    Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
  • 數據庫鏈接：

    HGNC: 18629

    OMIM: 608561

    KEGG: hsa:55576

    STRING: 9606.ENSP00000373539

    UniGene: Hs.408249



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