在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Spindle and kinetochore-associated protein 1 (SKA1)

Recombinant Human Spindle and kinetochore-associated protein 1 (SKA1)

  • 中文名稱：
    人SKA1重組蛋白
  • 貨號：
    CSB-YP846589HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SKA1重組蛋白
  • 貨號：
    CSB-EP846589HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SKA1重組蛋白
  • 貨號：
    CSB-EP846589HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SKA1重組蛋白
  • 貨號：
    CSB-BP846589HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SKA1重組蛋白
  • 貨號：
    CSB-MP846589HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SKA1
  • Uniprot No.：
  • 別名：
    2810433K01Rik; AV117428; C18orf24; MGC10200; Ska1; SKA1_HUMAN; Spindle and kinetochore associated complex subunit 1; Spindle and kinetochore associated protein 1; Spindle and kinetochore-associated protein 1; Spindle and KT (kinetochore) associated 1; Spindle and KT associated 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-255
  • 氨基酸序列
    ASSDLEQLC SHVNEKIGNI KKTLSLRNCG QEPTLKTVLN KIGDEIIVIN ELLNKLELEI QYQEQTNNSL KELCESLEED YKDIEHLKEN VPSHLPQVTV TQSCVKGSDL DPEEPIKVEE PEPVKKPPKE QRSIKEMPFI TCDEFNGVPS YMKSRLTYNQ INDVIKEINK AVISKYKILH QPKKSMNSVT RNLYHRFIDE ETKDTKGRYF IVEADIKEFT TLKADKKFHV LLNILRHCRR LSEVRGGGLT RYVIT
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules. In the complex, it mediates the interaction with microtubules.
  • 基因功能參考文獻：
    1. decreased neuronal cell SKA complex genes' expression levels affect neuronal cell viability and neurite development PMID: 29268205
    2. High SKA1 expression is associated with early recurrence and progression in patients with NMIBC, indicating SKA1 may serve as a promising prognostic biomarker for this disease. PMID: 29865039
    3. End-binding protein 1 (EB1) depletion results in a significant reduction of spindle and kinetochore-associated protein 1 (Ska1) recruitment onto microtubules and defects in mitotic chromosome alignment. PMID: 27225956
    4. SKA1 might be a promising target for cancer gene therapy in human ACC. PMID: 28340379
    5. Results show that SKA1 expression is regulated by mir-10a. Its knockdown inhibits migration and invasion in renal cell carcinoma cells. PMID: 28746769
    6. Study indicated that hypoxia mediated downregulation of SKA1 expression increased the chemotherapy resistance in human osteosarcoma cells. PMID: 28278080
    7. Kinetochores mature through Ska1/ska2/Ska3 complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint. PMID: 28495837
    8. In conclusion, our findings suggest that spindle and kinetochore-associated protein 1 could serve as a potential therapeutic target in prostate cancer patients. PMID: 28651496
    9. expression positively associated with tumor-node-metastasis stage and recurrence of salivary adenoid cystic carcinoma PMID: 26881872
    10. Thus, the Ska complex, specifically the Ska1 C-terminal domain, recruits PP1 to kinetochores to oppose spindle checkpoint signaling kinases and promote anaphase onset. PMID: 26981768
    11. SKA1 is required for metastasis and cisplatin resistance of non-small cell lung cancer. PMID: 26985856
    12. knockdown of SKA1 could potently suppress bladder cancer cell proliferation in vitro and lentivirus-mediated silencing of SKA1 might serve as a novel strategy for gene therapy of bladder cancer. PMID: 26197237
    13. Results show that high SKA1 expression is predictive of poor prognosis of papillary thyroid carcinoma (PTC), implying it as a promising new target for PTC therapies. PMID: 26063960
    14. SKA1 could be used for gastric cancer early diagnosis as a biomarker. PMID: 24627241
    15. the kinetochore-associated Ska complex interacts with tubulin monomers via the carboxy-terminal winged-helix domain of Ska1, providing the structural basis for the ability to bind both straight and curved microtubule structures. PMID: 24413531
    16. Ska1 over-expression promotes tumourigenesis PMID: 24827423
    17. Data suggest that SKA1 plays an important role in the proliferation of hepatocellular carcinoma cells PMID: 24010405
    18. the conserved kinetochore-localized Ska1 complex tracks with depolymerizing microtubule ends and associates with both the microtubule lattice and curved protofilaments PMID: 23085020
    19. The structure of the Ska core complex is a W-shaped dimer of coiled coils, formed by intertwined interactions between Ska1, Ska2, and Ska3. PMID: 22483620
    20. Data suggest that Aurora B phosphorylation antagonizes the interaction between the Ska1-3 complex and the KMN network, thereby controlling Ska recruitment to KTs and stabilization of KT-MT attachments. PMID: 22371557
    21. These data suggest that the Ska1/Ska2 complex plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing. PMID: 17093495
    22. The full Ska1 complex forms assemblies on microtubules that can facilitate the processive movement of microspheres along depolymerizing microtubules. PMID: 19289083

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    SKA1 family
  • 數據庫鏈接：

    HGNC: 28109

    OMIM: 616673

    KEGG: hsa:220134

    STRING: 9606.ENSP00000285116

    UniGene: Hs.134726



主站蜘蛛池模板： 天天躁日日躁狠狠躁av中文| 国产98在线 | 免费| 日韩亚洲欧美中文高清在线| 爽爽影院免费观看视频| 国产精品一区二区av| 极品粉嫩福利午夜在线播放| 国产一国产aa毛片| 久久人人爽天天玩人人妻精品| 亚洲熟妇色xxxxx亚洲| 亚洲爆乳成av人在线蜜芽| 国产av无码专区亚汌a√| 午夜成人无码福利免费视频| 私人毛片免费高清影视院| 国产又粗又猛又大爽老大爷| 成人无码嫩草影院| 国产拍揄自揄精品视频| 中文字幕亚洲无线码| 99久久久无码国产精品古装| 免费国产高清毛不卡片基地| 日韩欧美亚洲综合久久影院| 亚洲 欧美 国产 日韩 精品| 亚洲欧洲日产国码韩国| 国产日韩欧美亚欧在线观看| 色综合久久一区二区三区| 国产人澡人澡澡澡人碰视频| 亚洲中文有码字幕日本第一页| 亚洲另类激情专区小说| 无码丰满熟妇| 超碰国产精品人人做人人爱| 亚洲欧美中文高清在线专区 | 国产真实乱人偷精品人妻| 亚洲欧美一区二区三区| 女人与公拘交酡全过程| 文中字幕一区二区三区视频播放 | 国产超碰人人做人人爽av大片| 久久人人爽爽人人爽人人片av| 超碰人人超碰人人| 日本一区二区a√成人片| 亚洲人成日韩中文字幕无卡 | 99久久精品国产一区二区三区| 免费看撕开奶罩揉吮奶头视频|