在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Sorting nexin-6 (SNX6)

  • 中文名稱:
    人SNX6重組蛋白
  • 貨號:
    CSB-YP890766HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SNX6重組蛋白
  • 貨號:
    CSB-EP890766HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人SNX6重組蛋白
  • 貨號:
    CSB-EP890766HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SNX6重組蛋白
  • 貨號:
    CSB-BP890766HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SNX6重組蛋白
  • 貨號:
    CSB-MP890766HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    SNX6; Sorting nexin-6; TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6; N-terminally processed]
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-406
  • 氨基酸序列
    MMEGLDDGPD FLSEEDRGLK AINVDLQSDA ALQVDISDAL SERDKVKFTV HTKSSLPNFK QNEFSVVRQH EEFIWLHDSF VENEDYAGYI IPPAPPRPDF DASREKLQKL GEGEGSMTKE EFTKMKQELE AEYLAIFKKT VAMHEVFLCR VAAHPILRRD LNFHVFLEYN QDLSVRGKNK KEKLEDFFKN MVKSADGVIV SGVKDVDDFF EHERTFLLEY HNRVKDASAK SDRMTRSHKS AADDYNRIGS SLYALGTQDS TDICKFFLKV SELFDKTRKI EARVSADEDL KLSDLLKYYL RESQAAKDLL YRRSRSLVDY ENANKALDKA RAKNKDVLQA ETSQQLCCQK FEKISESAKQ ELIDFKTRRV AAFRKNLVEL AELELKHAKG NLQLLQNCLA VLNGDT
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B. May contribute to transcription regulation.
  • 基因功能參考文獻:
    1. study confirms the utility of proximity-labeling methods, such as BioID, to screen for interactors of cell-surface receptors and has uncovered a role of one of these interactors, SNX6, in the IGF1R signaling cascade. PMID: 29530981
    2. These results identify SNX6 as a key regulator of lamin A synthesis and incorporation into the nuclear envelope. PMID: 25535984
    3. Study observed that SNX6 increases BRMS1-dependent transcriptional repression. Moreover, over-expression of SNX6 was capable of diminishing trans-activation in a dose-dependent manner. PMID: 20830743
    4. SNX6 modulates the retrograde trafficking and basal levels of BACE1, thereby regulating BACE1-mediated APP processing and Abeta biogenesis PMID: 20354142
    5. These observations indicate that in addition to SNX1/2, SNX6 in association with the dynein/dynactin complex drives the formation and movement of tubular retrograde intermediates. PMID: 19935774
    6. SNX5 and SNX6 may constitute functional equivalents of Vps17p in mammalian retromer PMID: 17148574

    顯示更多

    收起更多

  • 亞細胞定位:
    Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm. Nucleus.
  • 蛋白家族:
    Sorting nexin family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14970

    OMIM: 606098

    KEGG: hsa:58533

    STRING: 9606.ENSP00000355217

    UniGene: Hs.276523



主站蜘蛛池模板: 天天做天天爱天天综合网| 日日摸日日碰夜夜爽av| 狂野欧美性猛交xxxx| 久久亚洲私人国产精品va| 午夜免费啪视频在线18| 成 人 网 站不卡在线观看| 国产良妇出轨视频在线观看| 亚洲人ⅴsaⅴ国产精品| 欧美性猛交xxxx免费看蜜桃| 色欲av无码一区二区三区| 成人午夜免费无码区| 成人无码亚洲精品无码| 成 人片 黄 色 大 片| 欧美黑人性暴力猛交喷水黑人巨大 | 国产色在线 | 亚洲| 精品麻豆国产色欲色欲色欲www| 国产亚洲曝欧美曝妖精品| 成人性做爰aaa片免费| 国产成人无码av| 久久久久久人妻毛片a片| 无码日韩做暖暖大全免费不卡 | 免费观看四虎精品国产地址| 男人猛躁进女人免费播放| 欧美牲交a欧美牲交aⅴ一| 国产亚洲美女精品久久久| 色猫咪免费人成网站在线观看| 人人超人人超碰超国产| 精品亚洲成a人在线观看| 伊人蕉久中文字幕无码专区| 樱花草在线社区www日本影院| 久久伊人av综合影院| 美女视频黄a视频全免费| 特殊重囗味sm在线观看无码| 色欲综合久久中文字幕网| 久久久久波多野结衣高潮| 久久久综合香蕉尹人综合网 | 天天拍夜夜添久久精品| 亚洲综合激情五月丁香六月 | 亚洲aⅴ综合av国产八av| 亚洲国产中文字幕在线视频综合| 狠狠色噜噜狠狠色综合久|