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  4. Recombinant Human Solute carrier family 22 member 7 (SLC22A7), partial

Recombinant Human Solute carrier family 22 member 7 (SLC22A7), partial

  • 中文名稱：
    人SLC22A7重組蛋白
  • 貨號：
    CSB-YP897308HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC22A7重組蛋白
  • 貨號：
    CSB-EP897308HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC22A7重組蛋白
  • 貨號：
    CSB-EP897308HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC22A7重組蛋白
  • 貨號：
    CSB-BP897308HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC22A7重組蛋白
  • 貨號：
    CSB-MP897308HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC22A7
  • Uniprot No.：
  • 別名：
    hOAT2; liver specific transporter; NLT; Novel liver transporter; OAT2; Organic anion transporter 2; Organic anion transporter member 7; Organic anion transporter member 7 Fragment; S22A7_HUMAN; SLC22A7; solute carrier family 22 (organic anion transporter) member 7; Solute carrier family 22; Solute carrier family 22 member 7
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.
  • 基因功能參考文獻：
    1. Lrh-1 transcriptionally regulates Oat2. PMID: 29669824
    2. two human organic anion transporters OAT2 and OAT7 activities were assessed. PMID: 28945155
    3. SLC22A7 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort. PMID: 28371506
    4. Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity. PMID: 26230641
    5. suggest that OAT2-mediated cGMP uptake does not occur via exchange with monocarboxylates, dicarboxylates, and hydroxyl ions PMID: 26377792
    6. the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine PMID: 25904762
    7. At physiologic creatinine concentrations, specific activity of OAT2 transport was over twofold higher than OCT2 or OCT3, establishing OAT2 as a likely creatinine transporter, challenging the view that creatinine is solely transported by a cationic pathway PMID: 24646860
    8. mitochondrial pathways may affect SLC 22A7 function to promote the occurrence of hepatocellular carcinoma PMID: 23543312
    9. Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2 PMID: 22981274
    10. Transport of the antivirals into human embryonic kidney cells was stimulated 10- to 20-fold by expression of OAT2. PMID: 22190696
    11. Expression of rat OAT2 in HEK (human embryonic kidney)-293 cells stimulates accumulation of zwitterion trigonelline; subsequently, orotic acid is identified as an excellent and specific substrate of OAT2 from human. PMID: 21446918
    12. results suggest that genetic polymorphisms may not be a significant contributing factor to variations in the hOAT2 expression or hOAT2 transport activity PMID: 19854166
    13. elucidation of the molecular mechanism for renal tetracycline transport by human organic anion transporters (hOATs) using proximal tubular cells stably expressing hOATs PMID: 11855680
    14. hOAT2 is a highly efficient, facilitative transporter of cGMP and may be involved in cGMP signaling in many tissues. PMID: 18216183

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  • 亞細胞定位：
    Basolateral cell membrane; Multi-pass membrane protein. Note=Apical side of the renal tubule.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 組織特異性：
    Expressed in liver and kidney.
  • 數據庫鏈接：

    HGNC: 10971

    OMIM: 604995

    KEGG: hsa:10864

    STRING: 9606.ENSP00000361666

    UniGene: Hs.485438



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