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  4. Recombinant Human Sodium- and chloride-dependent betaine transporter (SLC6A12), partial

Recombinant Human Sodium- and chloride-dependent betaine transporter (SLC6A12), partial

  • 中文名稱：
    人SLC6A12重組蛋白
  • 貨號：
    CSB-YP021690HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC6A12重組蛋白
  • 貨號：
    CSB-EP021690HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC6A12重組蛋白
  • 貨號：
    CSB-EP021690HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC6A12重組蛋白
  • 貨號：
    CSB-BP021690HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC6A12重組蛋白
  • 貨號：
    CSB-MP021690HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC6A12
  • Uniprot No.：
  • 別名：
    Betaine/GABA transporter 1; BGT-1; BGT1; Gamma aminobutyric acid transporter; GAT2; Na(+)/Cl(-) betaine/GABA transporter; S6A12_HUMAN; Slc6a12; Sodium- and chloride-dependent betaine transporter; Solute carrier family 6 (neurotransmitter transporter), member 12; Solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; Solute carrier family 6 member 12
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
  • 基因功能參考文獻：
    1. The SLC6A12 expression levels in peripheral blood mononuclear cells were significantly higher in TLE patients. PMID: 26690518
    2. T40 may be important for the trafficking and insertion of BGT1 in the plasma membrane PMID: 24829506
    3. JAK2 is a novel regulator of the GABA transporter BGT1. PMID: 22405821
    4. This study found that rs216250 of SLC6A12 was correlated with the Scale for the Assessment of Negative Symptoms (SANS) scores. PMID: 21367462
    5. Results showed that two polymorphisms and a haplotype in SLC6A12, were significantly associated with AIA after multiple testing corrections. PMID: 20597903
    6. The primary structure of BGT-1 predicts two putative phosphorylation sites for the Ca2+/diacylglycerol-dependent protein kinase (PKC), which regulates BGT-1 function by phosphorylation events in a transport system expressed in cultured astrocytoma cells. PMID: 12111824
    7. BGT-1 is expressed from mRNA and transports GABA in platelets. PMID: 16198020

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  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A12 subfamily
  • 組織特異性：
    Liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.
  • 數據庫鏈接：

    HGNC: 11045

    OMIM: 603080

    KEGG: hsa:6539

    STRING: 9606.ENSP00000352702

    UniGene: Hs.437174



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