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  4. Recombinant Human Single-stranded DNA-binding protein, mitochondrial (SSBP1)

Recombinant Human Single-stranded DNA-binding protein, mitochondrial (SSBP1)

  • 中文名稱：
    人SSBP1重組蛋白
  • 貨號：
    CSB-YP022706HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SSBP1重組蛋白
  • 貨號：
    CSB-EP022706HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SSBP1重組蛋白
  • 貨號：
    CSB-EP022706HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SSBP1重組蛋白
  • 貨號：
    CSB-BP022706HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SSBP1重組蛋白
  • 貨號：
    CSB-MP022706HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    mitochondrial; Mt SSB; Mt-SSB; MtSSB; PWP1 interacting protein 17; PWP1-interacting protein 17; SENSOR OF SINGLE-STRANDED DNA COMPLEX; Single stranded DNA binding protein 1; Single stranded DNA binding protein; Single stranded DNA binding protein mitochondrial; Single-stranded DNA-binding protein; SOSS B1; SOSS COMPLEX, SUBUNIT B1; SSBP 1; SSBP; SSBP_HUMAN; SSBP1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    17-148
  • 氨基酸序列
    ESET TTSLVLERSL NRVHLLGRVG QDPVLRQVEG KNPVTIFSLA TNEMWRSGDS EVYQLGDVSQ KTTWHRISVF RPGLRDVAYQ YVKKGSRIYL EGKIDYGEYM DKNNVRRQAT TIIADNIIFL SDQTKEKE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair.
  • 基因功能參考文獻：
    1. This study identified SSBP1 as a putative N6-methyldeoxyadenosine binding protein. PMID: 30412255
    2. NEIL1 and homotetrameric mtSSB form a larger ternary complex in presence of DNA, however, the tetrameric form of mtSSB gets disrupted by NEIL1 in the absence of DNA as revealed by the formation of a smaller NEIL1-mtSSBmonomer complex. PMID: 29522991
    3. These results indicated that SSDBP1 may induce cell chemoresistance of cisplatin through promoting DNA repair, resistance-related gene expression, cell proliferation, and inhibiting apoptosis. PMID: 28210897
    4. Data show that single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) forms a tetramer and is stabilized by two cysteines (C81 and C99) as well as a subset of charged and hydrophobic residues. PMID: 28609781
    5. DNA synthesis determines the binding mode of the human mtSSB. PMID: 28486639
    6. The data presented in this study suggests that while SSBP1 has predominantly been considered in a DNA repair context, it is likely to have roles in many other cellular processes. In particular, the identification of numerous proteins with roles in mRNA metabolism, transcriptional transactions and ribosomal processes, may suggest these as important areas of SSBP1 function. PMID: 27938330
    7. Data suggest that human mitochondrial SSB shares many physicochemical properties with E coli SSB and that the differences may be explained by the lack of an acidic, disordered C-terminal tail in human mitochondrial SSB protein. (SSB = single-stranded DNA-binding protein) PMID: 28615444
    8. Data suggest that human mitochondrial SSB and E coli SSB both protect and expose single-stranded DNA; implications from these studies toward understanding DNA replication and DNA repair abound. (SSB = single-stranded DNA-binding protein) [EDITORIAL] PMID: 28778884
    9. hSSB1 is directly phosphorylated by DNA-PK at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival. PMID: 28448822
    10. The stimulatory effect of mtSSB on Pol gamma on these ssDNA templates is not species-specific. PMID: 26446790
    11. This study determined that hSSB1 acetylation at K94 mediated by the acetyltransferase p300 and the deacetylases SIRT4 and HDAC10 impaired its ubiquitin-mediated degradation by proteasomes. PMID: 26170237
    12. SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity PMID: 25762445
    13. Fbxl5 interacts with and targets hSSB1 for ubiquitination and degradation, which could be prevented by ATM-mediated hSSB1 T117 phosphorylation. PMID: 25249620
    14. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites. PMID: 23986477
    15. Results indicate that hSSB1 may regulate DNA damage checkpoints by positively modulating p53 and its downstream target p21. PMID: 23184057
    16. mtSSB potentially prevents formation of DNA breaks in ssDNA, ensuring that base removal primarily occurs in dsDNA. PMID: 23290262
    17. Local enrichment of UNG1 at DNA-bound mtSSB may furthermore facilitate rapid access to- and processing of the damage once the dsDNA conformation is restored. PMID: 22153281
    18. mtSSB uses distinct structural elements to interact functionally with its mtDNA replisome partners and to promote proper mtDNA replication in animal cells PMID: 21953457
    19. hSSB1 may positively modulate p21 to regulate cell cycle progression and DNA damage response, implicating hSSB1 as a novel, promising therapeutic target for cancers such as hepatocellular carcinoma PMID: 21242961
    20. Results describe the role of mitochondrial single-stranded DNA binding protein in the maintenance of mitochondrial DNA in cultured human cells. PMID: 20434493
    21. Data show that mtSSB bound both CKS1 and CKS2 and underwent CDK-dependent phosphorylation. PMID: 19786724
    22. SSDP1 gene encodes a protein with a conserved N-terminal FORWARD domain;The SSDP1 mRNA transcripts are distributed ubiquitously in adult human and mouse tissues. PMID: 12479417
    23. PDIP38 is located in the mitochondrial matrix. TFAM and mitochondrial single-stranded DNA binding protein (mtSSB) are co-immunoprecipitated with PDIP38 PMID: 16428295
    24. Zta interaction with mtSSB serves the dual function of facilitating viral and blocking mitochondrial DNA replication. PMID: 18305033
    25. Identification of human mitochondrial SSB (HmtSSB) as a novel protein-binding partner of tumour suppressor p53, in mitochondria. PMID: 19066201
    26. hSSB1 and hSSB2 form two separate complexes with similar structures, and both complexes participate in DNA damage response. PMID: 19605351
    27. following DNA damage, SSB1 and Integrator3 relocate to the DNA damage sites and regulate the accumulation of TopBP1 and BRCA1 there PMID: 19759019

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  • 亞細胞定位：
    Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid.
  • 組織特異性：
    Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level).
  • 數據庫鏈接：

    HGNC: 11317

    OMIM: 600439

    KEGG: hsa:6742

    STRING: 9606.ENSP00000265304

    UniGene: Hs.490394



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