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  4. Recombinant Human Serum paraoxonase/arylesterase 2 (PON2)

Recombinant Human Serum paraoxonase/arylesterase 2 (PON2)

  • 中文名稱：
    人PON2重組蛋白
  • 貨號：
    CSB-YP613586HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PON2重組蛋白
  • 貨號：
    CSB-EP613586HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PON2重組蛋白
  • 貨號：
    CSB-EP613586HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PON2重組蛋白
  • 貨號：
    CSB-BP613586HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PON2重組蛋白
  • 貨號：
    CSB-MP613586HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PON2
  • Uniprot No.：
  • 別名：
    A esterase 2 ; A-esterase 2; Aromatic esterase 2; Paraoxonase 2; Paraoxonase nirs; PON 2; PON2; PON2_HUMAN; Serum aryldialkylphosphatase 2; Serum paraoxonase/arylesterase 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-354
  • 氨基酸序列
    MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH WANVVYYSPN EVKVVAEGFD SANGINISPD DKYIYVADIL AHEIHVLEKH TNMNLTQLKV LELDTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNNPPS SEVLRIQNIL CEKPTVTTVY ANNGSVLQGS SVASVYDGKL LIGTLYHRAL YCEL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.
  • 基因功能參考文獻(xiàn)：
    1. The decrease in monocyte/macrophage PON2 enzymatic activity observed in type 2 diabetes cannot be totally explained by abdominal obesity and insulin resistance. PMID: 28637359
    2. these results showed that PON2 could represent a molecular biomarker for bladder cancer and suggest a potential role of the enzyme as a prognostic factor for this neoplasm PMID: 28430636
    3. Study observed a genetic effect in ischemic stroke patients of the north area of the Gran Canaria island linked to the rs7493 variant in the PON2 gene with worse atherogenic ultrasonographic profile in ischemic stroke patients. Conversely, the Cys311Cys homozygosity, which is usually associated with an increased risk of stroke in the general population, was also related to a better ultrasonographic profile. PMID: 28566152
    4. Paraoxonase 2 (PON2) possesses antiatherogenic properties and is associated with lower Reactive Oxygen Species levels. PON2 is involved in the antioxidative and anti-inflammatory response in intestinal epithelial cells. PMID: 29308836
    5. PON2 is a new potential biomarker for therapy resistance or a prognostic tumor marker. PMID: 27322774
    6. PON-2 regulates ENaC activity by modulating its intracellular trafficking and surface expression PMID: 28768768
    7. Paraoxonase 2 facilitates pancreatic ductal cancer growth and metastasis by stimulating GLUT1-mediated glucose transport. PMID: 28803777
    8. Results suggest that valproic acid (VPA) reduces paraoxonase 2 (PON2) expression in glioblastoma multiforme (GBM) cells, which in turn increases reactive oxygen species (ROS) production and induces Bim protein production that inhibits cancer progression via the PON2-Bim cascade. PMID: 28108734
    9. High soluble expression levels were achieved with a yield of 76 mg of fully human PON2 variants per liter of culture media PMID: 27623343
    10. The PON2 Ser311Cys polymorphism is associated with coronary heart disease risk in Caucasians. PMID: 27609416
    11. Thi study found that the CC genotype of the PON2 S311C polymorphism is a risk factor for ischemic stroke. PMID: 26978533
    12. PON2 SNPs rs12026 and rs7493 were associated with intracerebral hemorrhage. The C alleles of rs12026 and rs7493 contributed to a decreased risk of ICH. PMID: 26227792
    13. Data indicate the relationship between ubiqutination of lysine (Lys) 168 and paraoxonase 2 (PON2) catalytic activity. PMID: 26656916
    14. D1-like receptors inhibit ROS production by altering PON2 distribution in membrane microdomains in the short-term, and by increasing PON2 expression in the long-term. PMID: 25740199
    15. PON2 is a central regulator of host cell responses to Pseudomonas aeruginosa N-(3-oxo-dodecanoyl)-L-homoserine lactone PMID: 26056385
    16. PON2 levels reflect the cells' irradiation sensitivity. PMID: 25708945
    17. Newborns with PON2 148AG/GG genotype and exposed to high concentrations of MBP and MEHP had higher risks of LBW and SBL PMID: 25913154
    18. A modest dose-dependent allele effect between the PON2 c.311C > G polymorphism, increased triglyceride concentrations and decreased LDL particle size distribution. PMID: 24807171
    19. Taken together, our data suggest a model by which DJ-1 exerts its antioxidant activities, at least partly through regulation of PON2. PMID: 25210784
    20. Maternal genetic susceptibility GSTT1 and PON2 rs12026 could significantly modify the association of organic solvents with gestational age. PMID: 24845160
    21. changes in PON2 in the placenta in labour PMID: 24816800
    22. PON2 and PON3 (i) are associated with mitochondria and mitochondria-associated membranes, (ii) modulate mitochondria-dependent superoxide production, and (iii) prevent apoptosis. PMID: 25038992
    23. There were no statistically significant differences among all comparisons in pon2 mutation in patient with ischemic stroke. PMID: 24636586
    24. No significant differences were found for PON2-311 genotypes or allele frequencies in patients with dementia due to Alzheimer's disease. PMID: 24088404
    25. S311C PON2 polymorphism is associated with the accelerated decline in kidney function in the chronic glomerulonephritis patients. PMID: 24727057
    26. Quercetin supplementation increases PON2 levels in cultured monocytes in vitro but not in human volunteers in vivo. PMID: 19865538
    27. Data indicate that paraoxonase 2 (PON2) is a transmembrane protein that localizes to the plasma membrane in small intestinal tissue. PMID: 24421402
    28. A case-control study of Chinese workers exposed to occupational noise, PON2 gene polymorphisms(rs7493, rs12026, rs7785846 and rs7786401)was associated with a higher risk to noise-induced hearing loss. No higher risk was found for genotype rs12704796. PMID: 23327886
    29. In the presence of metabolic syndrome and diabetes, PON2-311CC was associated with an increased risk of significant coronary stenosis. PMID: 23053877
    30. hypertension, HDL-cholesterol concentration, and the presence of C allele in PON2 gene were independently associated with atherothrombotic events; study sheds light on role of PON2 as a possible cofactor in determining risk of events together with the well-known risk markers HDL-cholesterol and hypertension PMID: 23225229
    31. Data suggest that mRNA expression and activity of PON-2 enzyme in monocytes and macrophages can be modulated by dietary factors (here, traditional Brazilian beverages/tea made from green or roasted yerba mate). PMID: 22964087
    32. lower PPARgamma and PON2 gene expression in the BALF of children with CF is associated specifically with P. aeruginosa infection and neutrophilia. PMID: 22860094
    33. Paraoxonase (PON) family members seem central to a wide variety of human illnesses, but appreciation of their antioxidative function in the gastrointestinal tract is in its infancy PMID: 22744335
    34. Low serum paraoxonase activity is a risk factor for Alzheimer disease; furthermore, multiple variants in PON influence serum paraoxonase activity and their effects may be synergistic. PMID: 20980077
    35. PON2 acts as a QS-quenching factor in keratinocytes and may have an important role in cutaneous defense against bacterial infections. PMID: 22534874
    36. The aim of this study was to perform a meta-analysis to investigate a more authentic association between PON2 Ser311Cys polymorphism and ischemic stroke. PMID: 22183305
    37. The association of PON2, with Parkinson's disease among Indians may point toward an inherent population-specific genetic predisposition PMID: 22016051
    38. Single-nucleotide polymorphisms in PON2 is associated with chronic kidney disease in Type 2 diabetes. PMID: 21765051
    39. the studied PON2 polymorphism is not associated with late-onset Alzheimer's disease PMID: 21757906
    40. Deficiency of PON2 caused apoptosis of selective tumor cells. PMID: 21368884
    41. The data of this study suggested that PON2 polymorphisms are not involved in ALS pathogenesis in an Italian population. PMID: 20381198
    42. This meta-analysis suggested no association between the PON2 polymorphisms and coronary heart disease risk. PMID: 21146823
    43. PON2 genetic variation is significantly and independently associated with variation in serum PON activity and no obvious association between PON2 tagSNPs and SLE risk. PMID: 21223581
    44. The PON2 311C allele is suggested as a possible predisposing factor for severe cases of ischemic stroke. PMID: 19930448
    45. genetic variants, including Ala/Ala of SCYA11 (eotaxin) Ala23Thr, Cys/Cys or Cys/Ser of PON2 (paraoxonase 2) Ser311Cys and Arg/Arg of ADRB3 (beta3-adrenergic receptor) Trp64Arg, were independently associated with incident cardiac end-point. PMID: 20536507
    46. PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity PMID: 20530481
    47. differences between PON2 mRNA and protein distributions could be due to missence mutations in the PON2 gene, causing nontranslation of mRNA to protein in some tissues PMID: 20503442
    48. a possible role for PON2 C311S polymorphism in the pathogenesis of cardiac ischemic damage PMID: 19540141
    49. PON2*S and apoE4 alleles have interactive effect on the development of the two most common forms of dementias AD and VD, and further support the hypothesis that cardiovascular factors contribute to the development of AD. PMID: 11803456
    50. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese. PMID: 14741412

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  • 亞細(xì)胞定位：
    Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Paraoxonase family
  • 組織特異性：
    Widely expressed with highest expression in liver, lung, placenta, testis and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9205

    OMIM: 602447

    KEGG: hsa:5445

    STRING: 9606.ENSP00000222572

    UniGene: Hs.514420



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