在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Serine/threonine-protein kinase haspin (GSG2)

Recombinant Human Serine/threonine-protein kinase haspin (GSG2)

  • 中文名稱：
    人HASPIN重組蛋白
  • 貨號：
    CSB-YP819485HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HASPIN重組蛋白
  • 貨號：
    CSB-EP819485HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HASPIN重組蛋白
  • 貨號：
    CSB-EP819485HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HASPIN重組蛋白
  • 貨號：
    CSB-BP819485HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HASPIN重組蛋白
  • 貨號：
    CSB-MP819485HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HASPIN
  • Uniprot No.：
  • 別名：
    germ cell associated 2; Germ cell-specific gene 2 protein; GSG2; H-haspin; Haploid germ cell-specific nuclear protein kinase; HASP_HUMAN; Serine/threonine-protein kinase haspin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-798
  • 氨基酸序列
    MAASLPGPGS RLFRTYGAAD GRRQRRPGRE AAQWFPPQDR RRFFNSSGSS DASIGDPSQS DDPDDPDDPD FPGSPVRRRR RRPGGRVPKD RPSLTVTPKR WKLRARPSLT VTPRRLGLRA RPPQKCSTPC GPLRLPPFPS RDSGRLSPDL SVCGQPRDGD ELGISASLFS SLASPCPGSP TPRDSVISIG TSACLVAASA VPSGLHLPEV SLDRASLPCS QEEATGGAKD TRMVHQTRAS LRSVLFGLMN SGTPEDSEFR ADGKNMRESC CKRKLVVGNG PEGPGLSSTG KRRATGQDSC QERGLQEAVR REHQEASVPK GRIVPRGIDR LERTRSSRKS KHQEATETSL LHSHRFKKGQ KLGKDSFPTQ DLTPLQNVCF WTKTRASFSF HKKKIVTDVS EVCSIYTTAT SLSGSLLSEC SNRPVMNRTS GAPSSWHSSS MYLLSPLNTL SISNKKASDA EKVYGECSQK GPVPFSHCLP TEKLQRCEKI GEGVFGEVFQ TIADHTPVAI KIIAIEGPDL VNGSHQKTFE EILPEIIISK ELSLLSGEVC NRTEGFIGLN SVHCVQGSYP PLLLKAWDHY NSTKGSANDR PDFFKDDQLF IVLEFEFGGI DLEQMRTKLS SLATAKSILH QLTASLAVAE ASLRFEHRDL HWGNVLLKKT SLKKLHYTLN GKSSTIPSCG LQVSIIDYTL SRLERDGIVV FCDVSMDEDL FTGDGDYQFD IYRLMKKENN NRWGEYHPYS NVLWLHYLTD KMLKQMTFKT KCNTPAMKQI KRKIQEFHRT MLNFSSATDL LCQHSLFK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
  • 基因功能參考文獻：
    1. The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B. PMID: 28343965
    2. The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved. PMID: 28343969
    3. Autosomal recessive RP associated with mutations in the male germ cell-associated kinase (MAK) gene is associated with preservation of foveal vision even in advanced stages of retinal degeneration despite similar rates of peripheral visual field loss to other forms of autosomal recessive RP PMID: 29103961
    4. This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors PMID: 27139824
    5. Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin pool. PMID: 25854549
    6. Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing. PMID: 24732914
    7. Haspin inhibitors reveal centromeric roles of Aurora B in chromosome movement and spindle checkpoint signaling PMID: 23071152
    8. Aurora B phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B and Haspin functions in mitosis PMID: 21658950
    9. findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells PMID: 20929775
    10. phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B during mitosis PMID: 20705812
    11. Haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. PMID: 19910498
    12. Haspin is a relatively newly discovered kinase that phosphorylates histone H3 during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW] PMID: 19997740
    13. This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis PMID: 15681610
    14. Haspin is required to maintain centromeric cohesion during mitosis. PMID: 17084365

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome. Cytoplasm, cytoskeleton, spindle. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, Haspin subfamily
  • 組織特異性：
    Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferatin
  • 數據庫鏈接：

    HGNC: 19682

    OMIM: 609240

    KEGG: hsa:83903

    STRING: 9606.ENSP00000325290

    UniGene: Hs.534059



主站蜘蛛池模板： 国产精品99精品无码视亚| 麻豆av一区二区天美传媒| 国产亚洲精品aaaa片app| 欧美猛少妇色xxxxx猛叫| 亚洲精品久久久久久婷婷| 免费国产a国产片高清网站 | 在线岛国片免费无码av| 精品国产免费观看久久久| 国产女人叫床高潮大片| 久久久久麻豆v国产精华液好用吗| 欧美影院成年免费版| 粗了大了 整进去好爽视频| 无码日本精品xxxxxxxxx| 久久人人97超碰爱香蕉| 精品一卡2卡三卡4卡乱码精品视频| 男女啪啦啦超猛烈动态图| 欧美老熟妇乱xxxxx| 久久精品国产99国产精品澳门 | 一区二区无码免费视频网站| 国产乱子伦精品免费视频| 国产亚洲精品第一综合麻豆| 性一交一乱一伦一色一情孩交| 日本簧片在线观看| 精品婷婷色一区二区三区| 久久免费精品国产72精品九九| 日本一区二区三区免费播放| 久久婷婷五月综合97色一本一本| 最爽无遮挡行房视频| 国产精品一区二区久久乐下载| 国内熟妇人妻色无码视频在线| 熟女人妻视频| 国产三级久久久精品麻豆三级| 男人边吻奶边挵进去视频| 欧美大香线蕉线伊人久久| 亚洲成av人片一区二区梦乃| 非洲人与性动交ccoo| 久久精品国产亚洲夜色av网站| 狠狠色噜噜狠狠狠狠米奇777| 精品无码专区毛片| 国产欧美久久一区二区三区 | 无码中出人妻中文字幕av|