在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Serine incorporator 5 (SERINC5), partial

Recombinant Human Serine incorporator 5 (SERINC5), partial

  • 中文名稱：
    人SERINC5重組蛋白
  • 貨號：
    CSB-YP021050HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SERINC5重組蛋白
  • 貨號：
    CSB-EP021050HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SERINC5重組蛋白
  • 貨號：
    CSB-EP021050HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SERINC5重組蛋白
  • 貨號：
    CSB-BP021050HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SERINC5重組蛋白
  • 貨號：
    CSB-MP021050HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SERINC5
  • Uniprot No.：
  • 別名：
    C5orf12; SERC5_HUMAN; SERINC5; Serine incorporator 5; TPO1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes.
  • 基因功能參考文獻：
    1. Experiments using SERINC5(S5) S5- SERINC2(S5) chimeric proteins revealed two functional domains for restriction: one necessary for S5 incorporation into virions, which does not seem to be necessary for restriction, and a second one necessary to change the HIV-1 envelope conformation, localize to DRMs, and block infection. PMID: 29268082
    2. Data suggest that restriction of HIV-1 particle infectivity by host-cell SERINC5 (which is antagonized by viral Nef) does not depend on alterations in lipid composition and organization of HIV-1 particles and suggest that channeling serine into lipid biosynthesis may not be a cardinal cellular function of SERINC5. (SERINC5 = serine incorporator 5; Nef = nef gene product, HIV1gp9) PMID: 28659343
    3. Ser5-001 isoform transcripts are produced at least 10-fold more than the others; only Ser5-001 produces stable proteins that are targeted to the plasma membrane; only Ser5-001 shows strong anti-HIV-1 activity; the extra transmembrane domain is required for Ser5 stable expression and plasma membrane localization; results suggest plasma membrane localization is required for Ser5 antiviral activity PMID: 28275190
    4. The increased HIV-1 sensitivity to anti-gp41 antibodies and peptides suggests that SER5 also delays refolding of the remaining fusion-competent Env trimers. PMID: 28179429
    5. results suggest that the antagonism of HIV-1 Nef to SERINC5 restriction of virion infectivity is mediated by a dual mechanism that is related to CD4 downregulation PMID: 27681140
    6. SERINC3 and SERINC5 together restricted HIV-1 replication, and this restriction was evaded by Nef PMID: 26416733
    7. identification of the host transmembrane protein SERINC5, and to a lesser extent SERINC3, as a potent inhibitor of HIV-1 particle infectivity that is counteracted by Nef PMID: 26416734
    8. results from a first genome-wide association study of Borderline personality disorder, which shows a promising signal on chromosome 5 corresponding to SERINC5, a protein involved in myelination. PMID: 23979607
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    10. the apparent occurrence of an unusual TG 3' splice site in intron 11 is discussed PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.; Cytoplasm, perinuclear region.
  • 蛋白家族：
    TDE1 family
  • 組織特異性：
    Highly expressed in placenta, skeletal muscle, spleen, thymus, testis and peripheral leukocyte and is expressed weakly in the heart, liver and fetal brain.
  • 數據庫鏈接：

    HGNC: 18825

    OMIM: 614551

    KEGG: hsa:256987

    STRING: 9606.ENSP00000420863

    UniGene: Hs.288232



主站蜘蛛池模板： 国产真实老熟女无套内射| 欧洲美女黑人粗性暴交视频| 精品国产经典三级在线看| 久久久久久伊人高潮影院| 国产高潮流白浆视频| 7777色鬼xxxx欧美色妇| 99国产精品久久久久久久成人热 | 两性色午夜视频免费老司机| 久久精品无码一区二区www| 少妇又色又紧又爽又刺激视频| 精品国产av一二三四区| 久久久久女教师免费一区| 亚洲第一极品精品无码| 伊人精品成人久久综合| 图片区小说区另类春色| 亚洲老熟女性亚洲| 少妇久久久久久久久久| 无码人妻视频一区二区三区| 18禁黄网站禁片免费观看国产| 又黄又湿啪啪响18禁| 亚洲精品黑牛一区二区三区| 真人与拘做受免费视频| 双腿张开被9个男人调教| 又湿又黄裸乳漫画无遮挡网站| 天堂亚洲国产中文在线| 黑人巨大精品欧美一区二区免费| 久久精品中文字幕无码绿巨人| 国产综合色产在线精品| 最新国产精品好看的精品 | 亚洲va久久久噜噜噜久久男同| 亚洲va在线va天堂va欧美va| 天堂中文在线8最新版地址 | 一二三四在线观看免费视频| 在线亚洲高清揄拍自拍一品区| 五月婷婷久久草| 国产成人无码a区视频在线观看| 欧美孕妇变态重口另类| 久久中文精品无码中文字幕| 波多野结衣超清无码专区| 久久国产一区二区三区| 国产精品videossex久久发布|