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  4. Recombinant Human Serine hydroxymethyltransferase, mitochondrial (SHMT2)

Recombinant Human Serine hydroxymethyltransferase, mitochondrial (SHMT2)

  • 中文名稱：
    人SHMT2重組蛋白
  • 貨號：
    CSB-YP021274HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SHMT2重組蛋白
  • 貨號：
    CSB-EP021274HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SHMT2重組蛋白
  • 貨號：
    CSB-EP021274HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SHMT2重組蛋白
  • 貨號：
    CSB-BP021274HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SHMT2重組蛋白
  • 貨號：
    CSB-MP021274HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SHMT2
  • Uniprot No.：
  • 別名：
    Epididymis secretory sperm binding protein Li 51e; GLY A+; GLYA; glycine auxotroph A; human complement for hamster; Glycine hydroxymethyltransferase; GLYM_HUMAN; HEL S 51e; mitochondrial; Serine hydroxymethyltransferase 2 (mitochondrial); Serine hydroxymethyltransferase; Serine hydroxymethyltransferase mitochondrial; Serine methylase; SHMT 2; SHMT; SHMT2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    30-504
  • 氨基酸序列
    N AAQTQTGEAN RGWTGQESLS DSDPEMWELL QREKDRQCRG LELIASENFC SRAALEALGS CLNNKYSEGY PGKRYYGGAE VVDEIELLCQ RRALEAFDLD PAQWGVNVQP YSGSPANLAV YTALLQPHDR IMGLDLPDGG HLTHGYMSDV KRISATSIFF ESMPYKLNPK TGLIDYNQLA LTARLFRPRL IIAGTSAYAR LIDYARMREV CDEVKAHLLA DMAHISGLVA AKVIPSPFKH ADIVTTTTHK TLRGARSGLI FYRKGVKAVD PKTGREIPYT FEDRINFAVF PSLQGGPHNH AIAAVAVALK QACTPMFREY SLQVLKNARA MADALLERGY SLVSGGTDNH LVLVDLRPKG LDGARAERVL ELVSITANKN TCPGDRSAIT PGGLRLGAPA LTSRQFREDD FRRVVDFIDE GVNIGLEVKS KTAKLQDFKS FLLKDSETSQ RLANLRQRVE QFARAFPMPG FDEH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex.
  • 基因功能參考文獻：
    1. Findings support the hypothesis that age-associated respiration defects in fibroblasts of elderly humans are caused not by mtDNA mutations but by epigenetic regulation of nuclear genes including SHMT2. PMID: 29323231
    2. SHMT2 Desuccinylation is associated with Cancer Cell Proliferation. PMID: 29180469
    3. Our data confirm the heterogeneity of breast tumors at a functional proteomic level and dissects the relationship between metabolism-related proteins, pathological features and patient survival. These observations highlight the importance of SHMT2 and ASCT2 as valuable individual prognostic markers and potential targets for personalized breast cancer therapy PMID: 29020998
    4. Data suggest that serine hydroxymethyltransferase 2 (SHMT2) may be a potential target in the treatment of hepatocellular carcinoma (HCC). PMID: 27391339
    5. High SHMT2 expression is associated with idiopathic pulmonary fibrosis. PMID: 27836973
    6. These results indicate that SHMT2 may be a valuable prognostic biomarker in ER-negative breast cancer cases PMID: 27666119
    7. our results for the first time showed that miR-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC. PMID: 26662310
    8. The SHMT-2 is the direct targets of miR-370 and miR-373, respectively, in human articular chondrocytes. PMID: 26103880
    9. High SHMT2 expression increases glycine-dependent nucleotide synthesis leading to bladder cancer growth. PMID: 26975021
    10. SHMT2 is required for glioblastoma multiforme cells to adapt to the tumour environment, but also renders these cells sensitive to glycine cleavage system inhibition PMID: 25855294
    11. This paper compares the mitochondrial and cytoplasmic forms of this enzyme and suggests that the two genes are a result of a single gene duplication. PMID: 9573390

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  • 亞細胞定位：
    Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane. Cytoplasm. Nucleus.
  • 蛋白家族：
    SHMT family
  • 數據庫鏈接：

    HGNC: 10852

    OMIM: 138450

    KEGG: hsa:6472

    STRING: 9606.ENSP00000333667

    UniGene: Hs.741179



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