在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Sentrin-specific protease 3 (SENP3)

Recombinant Human Sentrin-specific protease 3 (SENP3)

  • 中文名稱：
    人SENP3重組蛋白
  • 貨號(hào)：
    CSB-YP887980HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人SENP3重組蛋白
  • 貨號(hào)：
    CSB-EP887980HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人SENP3重組蛋白
  • 貨號(hào)：
    CSB-EP887980HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SENP3重組蛋白
  • 貨號(hào)：
    CSB-BP887980HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SENP3重組蛋白
  • 貨號(hào)：
    CSB-MP887980HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SENP3
  • Uniprot No.：
  • 別名：
    SENP3; SENP3_HUMAN; Sentrin / SUMO specific protease 3; Sentrin specific protease 3; Sentrin-specific protease 3; Sentrin/SUMO-specific protease SENP3; SMT3IP1; SSP3; SUMO 1 specific protease 3; SUMO-1-specific protease 3; SUMO1 specific protease 3 ; SUMO1/sentrin/SMT3 specific peptidase 3; SUSP3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-574
  • 氨基酸序列
    MKETIQGTGS WGPEPPGPGI PPAYSSPRRE RLRWPPPPKP RLKSGGGFGP DPGSGTTVPA RRLPVPRPSF DASASEEEEE EEEEEDEDEE EEVAAWRLPP RWSQLGTSQR PRPSRPTHRK TCSQRRRRAM RAFRMLLYSK STSLTFHWKL WGRHRGRRRG LAHPKNHLSP QQGGATPQVP SPCCRFDSPR GPPPPRLGLL GALMAEDGVR GSPPVPSGPP MEEDGLRWTP KSPLDPDSGL LSCTLPNGFG GQSGPEGERS LAPPDASILI SNVCSIGDHV AQELFQGSDL GMAEEAERPG EKAGQHSPLR EEHVTCVQSI LDEFLQTYGS LIPLSTDEVV EKLEDIFQQE FSTPSRKGLV LQLIQSYQRM PGNAMVRGFR VAYKRHVLTM DDLGTLYGQN WLNDQVMNMY GDLVMDTVPE KVHFFNSFFY DKLRTKGYDG VKRWTKNVDI FNKELLLIPI HLEVHWSLIS VDVRRRTITY FDSQRTLNRR CPKHIAKYLQ AEAVKKDRLD FHQGWKGYFK MNVARQNNDS DCGAFVLQYC KHLALSQPFS FTQQDMPKLR RQIYKELCHC KLTV
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
  • 基因功能參考文獻(xiàn)：
    1. Important role of SENP3 in lipid metabolism during the development of non-alcoholic fatty liver disease. PMID: 27853276
    2. SENP3 knockdown reduced cadmium-induced caspase 3 cleavage and cell death in PC12 cells, while SENP3 overexpression enhanced cell death. PMID: 28747609
    3. Our data identified SUMOylation as a previously undescribed post-translational modification of STAT3 and SENP3 as a critical positive modulator of tobacco- or cytokine-induced STAT3 activation. PMID: 27181202
    4. The data demonstrate that SUMO2 conjugation and SENP3-driven deSUMOylation of PELP1 is instrumental for ordered progression of ribosome maturation, and they provide molecular insight into the dynamics of ribosome maturation. PMID: 27814492
    5. our findings for the first time specifically supported that SUMO-specific protease 3 might play an important role in the regulation of epithelial ovarian cancer progression and could serve as a potential biomarker for prognosis as well as provide a promising therapeutic target against epithelial ovarian cancer PMID: 28351334
    6. In early-onset pre-eclampsia, enhanced deSUMOylation of HIF1A by SENP3 may in part contribute to increased HIF1A activity and stability found in this pathology. PMID: 27016777
    7. High SENP3 expression is associated with stomach neoplasms. PMID: 26511642
    8. SENP3, which is increased in gastric cancer cells, potentiates the transcriptional activity of FOXC2 through de-SUMOylation, in favor of the induction of specific mesenchymal gene expression in gastric cancer metastasis. PMID: 25216525
    9. Evidence show that mTOR-mediated phosphorylation of SENP3 facilitates the interaction with NPM1, thereby promoting nucleolar targeting. PMID: 25288641
    10. SENP3 is associated with MLL1/MLL2 complexes and catalyzes deSUMOylation of RbBP5. PMID: 24930734
    11. ROS induced SENP3 redistribution from the nucleoli to the nucleoplasm. PMID: 23467634
    12. The shift of HIF-1 transactivation by reactive oxidative species is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status. PMID: 22684029
    13. These results suggest that SMT3IP1 is a new regulator of the p53-Mdm2 pathway. PMID: 21316347
    14. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. PMID: 20181954
    15. Results demonstrate that SENP1 is the most efficient SUMO protease acting on Elk-1, and that SENP3 has little effect on Elk-1. SENP2 has an intermediate effect, but its ability to activate Elk-1 is independent from its SUMO-deconjugating activity. PMID: 20337593
    16. These results define SENP3 as an essential factor for ribosome biogenesis and suggest that deconjugation of SUMO2 from NPM1 by SENP3 is critically involved in 28S rRNA maturation. PMID: 18259216
    17. SMT3IP1 desumoylates nucleophosmin and might controls its physiological functions at both the nucleolus and other subcellular compartments. PMID: 18639523
    18. Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway. PMID: 18946085
    19. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. PMID: 19015314
    20. SENP3 is a redox sensor that regulates HIF-1 transcriptional activity under oxidative stress through the de-SUMOylation of p300 PMID: 19680224

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm.
  • 蛋白家族：
    Peptidase C48 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17862

    OMIM: 612844

    KEGG: hsa:26168

    STRING: 9606.ENSP00000403712

    UniGene: Hs.513926



主站蜘蛛池模板： 国产真实露脸乱子伦 | 国产三级aⅴ在在线观看| 亚洲中文字幕无码乱线| 无遮挡又黄又刺激的视频| 亚洲性无码av中文字幕| 国产女人高潮抽搐叫床视频| 日韩一区二区三区四区区区| 夜夜躁狠狠躁日日躁| 国产精品国产三级国产普通话| 亚洲 欧美 另类 制服 日韩| 天天爽夜夜爽视频精品| 日韩激情无码不卡码| 天堂中文在线资源| 精品一卡二卡三卡四卡网站 | 成人一区二区免费视频| 非洲黑人最猛性xxxx交| 欧美尺码专线欧洲b1b1| 男女做爰猛烈啪啪吃奶伸舌头下载| 国产女人乱人伦精品一区二区| 国产无套内射久久久国产| 亚洲人成伊人成综合网中文| 人妻无码中文字幕永久在线| 久久av无码精品人妻糸列| 亚洲产国偷v产偷v自拍色戒| 国产成人92精品午夜福利| 亚洲一卡2卡3卡4卡5卡乱码观看| 中文字幕丰满孑伦无码专区 | 国产卡二卡三卡四卡免费网址| 中文字幕亚洲码在线| 亚洲国产精品成人久久| 国产黄网永久免费视频大全| 国产农村乱子伦精品视频| 制服 丝袜 人妻 专区一本| 久久婷婷五月综合色欧美| 亚洲欧美日韩在线资源观看| 337p日本欧洲亚洲大胆在线| 熟妇女人妻丰满少妇中文字幕| 国产女人喷潮视频免费| 五 月 丁 香 综合中文| 亚洲人成网站18禁止无码| 亚洲aⅴ在线无码天堂777|