在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human SPRY domain-containing SOCS box protein 1 (SPSB1)

In Stock
  • 中文名稱:
    人SPSB1重組蛋白
  • 貨號:
    CSB-EP853389HUa0
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    SPSB1
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    36.9 kDa
  • 表達區域:
    1-273aa
  • 氨基酸序列
    MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
  • 基因功能參考文獻:
    1. EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1. PMID: 28084329
    2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain. PMID: 26032413
    3. Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer. PMID: 24786206
    4. SSB1/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability. PMID: 19683501
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytosol.
  • 蛋白家族:
    SPSB family
  • 數據庫鏈接:

    HGNC: 30628

    OMIM: 611657

    KEGG: hsa:80176

    STRING: 9606.ENSP00000330221

    UniGene: Hs.738680



主站蜘蛛池模板: 九九线精品视频在线观看 | 免费看又色又爽又黄的国产软件| 亚洲国产av精品一区二区蜜芽| 最新av偷拍av偷窥av网站| 久久久婷婷五月亚洲97号色| 色8激情欧美成人久久综合电影| 天堂va欧美ⅴa亚洲va在线| 老熟女高潮喷水了| 国产精品日韩av在线播放| 亚洲中文字幕久久精品无码va| 西西人体www44rt大胆高清| 无码人妻精品一区二区蜜桃色欲| 麻豆av一区二区三区久久| 夜晚被公侵犯的人妻深田字幕| 亚洲国产精品久久久久秋霞小| 久久超乳爆乳中文字幕| 天天操夜夜操| 国产亚洲精品电影网站在线观看| 国产欧美成人一区二区a片| 亚洲国产aⅴ成人精品无吗 | 国产成人精品无码a区在线观看| 狠狠色婷婷久久一区二区三区| 色综合色欲色综合色综合色综合r| 西西艺术人像摄影| 免费裸体无遮挡黄网站免费看| 国产一区二区三区成人欧美日韩在线观看| 欧美日韩不卡高清在线看| 成人网站www污污污网站 | 亚洲日韩va无码中文字幕| 国内裸体无遮挡免费视频| av无码人妻波多野结衣| 亚洲精品久久久久中文字幕| 色狠狠色噜噜av天堂一区| 国产欧美另类精品久久久| 大伊香蕉精品视频在线| 国产免费视频| 久久综合给合久久国产免费| 日亚韩在线无码一区二区三区| 中文字幕色av一区二区三区| 欧美亚洲日韩国产综合电影| 国产一卡二卡三新区2022|