在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human SPRY domain-containing SOCS box protein 1 (SPSB1)

In Stock
  • 中文名稱:
    人SPSB1重組蛋白
  • 貨號:
    CSB-EP853389HUa0
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    SPSB1
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    36.9 kDa
  • 表達區域:
    1-273aa
  • 氨基酸序列
    MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
  • 基因功能參考文獻:
    1. EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1. PMID: 28084329
    2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain. PMID: 26032413
    3. Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer. PMID: 24786206
    4. SSB1/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability. PMID: 19683501
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytosol.
  • 蛋白家族:
    SPSB family
  • 數據庫鏈接:

    HGNC: 30628

    OMIM: 611657

    KEGG: hsa:80176

    STRING: 9606.ENSP00000330221

    UniGene: Hs.738680



主站蜘蛛池模板: 无码欧美黑人xxx一区二区三区 | 久久国产中文娱乐网| 天天狠天天透天天伊人| 精品久久久久久人妻无码中文字幕| 国产成人精品福利网站| 啪啪后入内射日韩| 99精品国产一区二区三区a片| 久久久久波多野结衣高潮| 亚洲人午夜射精精品日韩| 国产成人欧美日本在线观看| 国产日产欧产美韩系列影片| 欧美大胆少妇bbw| 日本丰满少妇高潮呻吟| 在线看片免费人成视频影院看| 午夜福利av无码一区二区| 特黄特色大片免费播放| 不卡无码av一区二区三区| 亚洲精品久久66国产高清| 午夜精品一区二区三区在线视| 国产精品免费观看久久| 亚洲aⅴ在线无码天堂777| 成人黄网站高清免费视频| 亚洲成av人片在线观看无码| 日韩日韩日韩日韩日韩| 99久久免费国产精品四虎| 国内极度色诱视频网站| 五月开心播播网| 无码人妻aⅴ一区二区三区玉蒲团 日本三级香港三级人妇三 | 日本无码人妻精品一区二区蜜桃| 亚洲精品aa片在线观看国产| 国产美女自慰在线观看| 久久影院午夜理论片无码| 国精品人妻无码一区二区三区性色| 国内揄拍国内精品少妇| 边添小泬边狠狠躁视频| 久久亚洲道色宗和久久| 欧美潮喷少妇100| 亚洲人精品午夜射精日韩| 丁香五月缴情在线| 久久人搡人人玩人妻精品| 少妇饥渴xxhd麻豆xxhd骆驼|