在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human SPRY domain-containing SOCS box protein 1 (SPSB1)

In Stock
  • 中文名稱:
    人SPSB1重組蛋白
  • 貨號:
    CSB-EP853389HUa0
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    SPSB1
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    36.9 kDa
  • 表達區域:
    1-273aa
  • 氨基酸序列
    MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
  • 基因功能參考文獻:
    1. EGF signaling upregulates an E3 ubiquitin (Ub) ligase adaptor, SPRY domain-containing SOCS box protein 1 (SPSB1), which recruits Elongin B/C-Cullin complexes to conjugate lysine 29-linked poly Ubiquitin chains onto hnRNP A1. PMID: 28084329
    2. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain. PMID: 26032413
    3. Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer. PMID: 24786206
    4. SSB1/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability. PMID: 19683501
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytosol.
  • 蛋白家族:
    SPSB family
  • 數據庫鏈接:

    HGNC: 30628

    OMIM: 611657

    KEGG: hsa:80176

    STRING: 9606.ENSP00000330221

    UniGene: Hs.738680



主站蜘蛛池模板: 日本xxx在线观看免费播放| 老司机久久精品最新免费| 国产精品边做奶水狂喷无码| 又爽又黄又无遮挡的激情视频| 女女女女女裸体处开bbb| 色情无码www视频无码区小黄鸭| 自慰系列无码专区| 一本一本久久a久久综合精品 | 欧美日韩不卡高清在线看| 国产免费一区二区三区不卡| 国产一区二区三区在线观看免费| 丰满多毛的大隂户视频| 白丝乳交内射一二三区| 一区二区三区四区在线 | 欧洲| 曰本av中文字幕一区二区| 国产午夜福利在线播放| 精产国品一二三产区m553麻豆| 国模裸体无码xxxx视频| 成在线人av无码高潮喷水| 性亚洲videofree高清| 成人动漫综合网| 亚洲中文字幕无码av永久| 亚洲欧美成人综合图区| 久久97超碰色中文字幕总站| 强行糟蹋人妻hd中文字| 国产日韩欧美亚洲精品中字| 国产熟妇精品高潮一区二区三区| 国产日韩欧美一区二区东京热| 国产精品186在线观看在线播放| 久久精品国产精油按摩| 欧美va久久久噜噜噜久久| 黑人巨茎美女高潮视频| 国内精品久久久久久久影视| 2021久久超碰国产精品最新| 国产免费又色又爽粗视频| 夜夜爽一区二区三区精品| 无码中字出轨中文人妻中文中| 国产又色又爽又黄的视频在线| 精品一区二区三区免费毛片爱 | 少妇激情艳情综合小视频| 国产成人无码aⅴ片在线观看|