在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human SOSS complex subunit B1 (OBFC2B)

  • 中文名稱:
    人NABP2重組蛋白
  • 貨號:
    CSB-YP858412HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NABP2重組蛋白
  • 貨號:
    CSB-EP858412HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NABP2重組蛋白
  • 貨號:
    CSB-EP858412HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NABP2重組蛋白
  • 貨號:
    CSB-BP858412HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NABP2重組蛋白
  • 貨號:
    CSB-MP858412HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    NABP2
  • Uniprot No.:
  • 別名:
    NABP2; OBFC2B; SSB1; LP3587; SOSS complex subunit B1; Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-211
  • 氨基酸序列
    MTTETFVKDI KPGLKNLNLI FIVLETGRVT KTKDGHEVRT CKVADKTGSI NISVWDDVGN LIQPGDIIRL TKGYASVFKG CLTLYTGRGG DLQKIGEFCM VYSEVPNFSE PNPEYSTQQA PNKAVQNDSN PSASQPTTGP SAASPASENQ NGNGLSAPPG PGGGPHPPHT PSHPPSTRIT RSQPNHTPAG PPGPSSNPVS NGKETRRSSK R
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
  • 基因功能參考文獻:
    1. findings demonstrate a novel hSSB1 regulatory mechanism for the repair of damaged DNA PMID: 27273218
    2. Our data highlights that BLM helicase and hSSB1 function in a dynamic complex in cells and that this complex is likely required for BLM protein stability and function. PMID: 28506294
    3. the detailed molecular mechanism in solution of ssDNA binding by hSSB1, a major player in the maintenance of genomic stability, is reported. PMID: 27387285
    4. In the absence of hSSB1, human 8-oxoguanine glycosylase 1 does not localize to chromatin, resulting in the accumulation of 8-oxoguanine in the genome. PMID: 26261212
    5. The findings demonstrate the importance of hSSB1 in maintaining and repairing DNA replication forks and for overall genomic stability. PMID: 24753408
    6. Identification of EEf1E1 and OBFC2B as novel BRCA1-partner genes in the DNA double-strand break repair pathway. PMID: 24104880
    7. SOSS complexes, containing SSB1, do not localize with Replication Protein A (RPA) to replication sites in human cells, yet have a strong effect on double-strand break resection and homologous recombination. PMID: 23178594
    8. Cells deficient in hSSB1 exhibit increased radiosensitivity, defective checkpoint activation and enhanced genomic instability coupled with a diminished capacity for DNA repair. PMID: 18449195
    9. INTS3 controls the SSB1-mediated DNA damage response. PMID: 19786574

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment.
  • 蛋白家族:
    SOSS-B family, SOSS-B1 subfamily
  • 數據庫鏈接:

    HGNC: 28412

    OMIM: 612104

    KEGG: hsa:79035

    STRING: 9606.ENSP00000267023

    UniGene: Hs.240170



主站蜘蛛池模板: 国产乱辈通伦影片在线播放亚洲| 特黄做受又硬又粗又大视频小说| 久久精品囯产精品亚洲| 国产精品成人永久在线四虎| 久久精品囯产精品亚洲| 国产亚洲精品a片久久久| 337p粉嫩大胆色噜噜噜| 欧美午夜精品久久久久久浪潮| 欧美亚洲精品中文字幕乱码| 人人妻人人澡人人爽国产| 无码免费无线观看在线视| 麻豆国产精成人品观看免费| 日本阿v网站在线观看中文| 亚洲欧美精品伊人久久| 香港经典a毛片免费观看hd| 亚洲精品一区二区国产精华液| 亚洲色成人www永久在线观看| 久久99精品久久久久久| 久久国产劲暴∨内射新川| 免费人成视频网站在线下载| 好吊射视频988gaocom| 精品香蕉99久久久久网站| 狼色精品人妻在线视频| 亚洲理论在线a中文字幕| 国产精品亚洲二区在线看| 国产欧美日韩va另类在线播放| av在线观看地址| 中文天堂在线www最新版官网| 成年女人看片永久免费视频 | 久久亚洲精品中文字幕无码| 乱子伦一区二区三区| 猫咪www免费人成网站无码| 免费人成网站视频在线观看国内 | 国产午夜福利久久精品| 国产真人做爰毛片视频直播 | 色综合久久久久综合99| 国产成人精品日本亚洲语音| 国产午夜毛片v一区二区三区 | 久久精品国产色蜜蜜麻豆| 亚洲国产精品久久久天堂麻豆宅男| 欧洲黑大粗无码免费|