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  4. Recombinant Human SH3 and PX domain-containing protein 2B (SH3PXD2B), partial

Recombinant Human SH3 and PX domain-containing protein 2B (SH3PXD2B), partial

  • 中文名稱：
    人SH3PXD2B重組蛋白
  • 貨號：
    CSB-YP021240HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SH3PXD2B重組蛋白
  • 貨號：
    CSB-EP021240HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SH3PXD2B重組蛋白
  • 貨號：
    CSB-EP021240HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SH3PXD2B重組蛋白
  • 貨號：
    CSB-BP021240HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SH3PXD2B重組蛋白
  • 貨號：
    CSB-MP021240HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SH3PXD2B
  • Uniprot No.：
  • 別名：
    SH3PXD2B; FAD49; KIAA1295; TKS4; SH3 and PX domain-containing protein 2B; Adapter protein HOFI; Factor for adipocyte differentiation 49; Tyrosine kinase substrate with four SH3 domains
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
  • 基因功能參考文獻：
    1. We report a sibling pair with Frank-ter Haar syndrome (FTHS) caused by a homozygous, novel mutation pLys133Glnfs*13 in the SH3PXD2B gene. PMID: 29100834
    2. Suggest the importance of Tks adaptor proteins in melanoma growth and metastasis in vivo is likely via functional invadopodia formation. PMID: 27802184
    3. Misfolded Frank-ter Haar syndrome protein Tks4(R43W) is transported via the microtubule system to the aggresomes. PMID: 26183326
    4. a new function for Tks4 in the regulation of growth factor-dependent cell migration. PMID: 22829589
    5. SH3PXD2B is a scaffold protein that plays a key role in regulating the actin cytoskeleton via Src and cortactin. PMID: 21886807
    6. Tks4 and Tks5 directly bind to NoxA1. The integrity of the N-terminal PRR of NoxA1 is essential for this direct interaction with the Tks proteins. PMID: 20609497
    7. The Nox1-dependent generation of reactive oxygen species is dependent on Src phosphorylation of NoxA1 and Tks4. Blockage of phosphorylation of NoxA1 and Tks4 decreases Nox1-dependent ROS generation and blocks SrcYF-induced invadopodia formation. PMID: 20943948
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    9. These findings establish a role for TKS4 in Frank-Ter Haar syndrome and embryonic development. PMID: 20137777
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 19228371

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  • 相關疾?。?/div>
    Frank-Ter Haar syndrome (FTHS)
  • 亞細胞定位：
    Cytoplasm. Cell projection, podosome.
  • 蛋白家族：
    SH3PXD2 family
  • 組織特異性：
    Expressed in fibroblasts.
  • 數據庫鏈接：

    HGNC: 29242

    OMIM: 249420

    KEGG: hsa:285590

    STRING: 9606.ENSP00000309714

    UniGene: Hs.285666



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