在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human S-adenosylmethionine synthase isoform type-1 (MAT1A)

Recombinant Human S-adenosylmethionine synthase isoform type-1 (MAT1A)

  • 中文名稱：
    人MAT1A重組蛋白
  • 貨號：
    CSB-YP013516HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MAT1A重組蛋白
  • 貨號：
    CSB-EP013516HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MAT1A重組蛋白
  • 貨號：
    CSB-BP013516HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MAT1A重組蛋白
  • 貨號：
    CSB-MP013516HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MAT1A
  • Uniprot No.：
  • 別名：
    MAT1A; AMS1; MATA1S-adenosylmethionine synthase isoform type-1; AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-395
  • 氨基酸序列
    MNGPVDGLCD HSLSEGVFMF TSESVGEGHP DKICDQISDA VLDAHLKQDP NAKVACETVC KTGMVLLCGE ITSMAMVDYQ RVVRDTIKHI GYDDSAKGFD FKTCNVLVAL EQQSPDIAQC VHLDRNEEDV GAGDQGLMFG YATDETEECM PLTIILAHKL NARMADLRRS GLLPWLRPDS KTQVTVQYMQ DNGAVIPVRI HTIVISVQHN EDITLEEMRR ALKEQVIRAV VPAKYLDEDT VYHLQPSGRF VIGGPQGDAG VTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW VAKSLVKAGL CRRVLVQVSY AIGVAEPLSI SIFTYGTSQK TERELLDVVH KNFDLRPGVI VRDLDLKKPI YQKTACYGHF GRSEFPWEVP RKLVF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
  • 基因功能參考文獻：
    1. Increased MAT1A expression is associated with recurrence in hepatocellular carcinoma. PMID: 29448301
    2. Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR of CD44 was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44. PMID: 27816361
    3. A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively. PMID: 28186605
    4. S-adenosyl-L-methionine diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes. PMID: 27076759
    5. 5-Aza-CdR showed no effects on MAT2A methylation. PMID: 24377546
    6. The mutations in the other 10 patients showed autosomal recessive inheritance and included eight novel MAT1A mutations. PMID: 24231718
    7. Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B. PMID: 23425511
    8. Methionine adenosyltransferase I/III deficiency is caused by mutations in the MAT1A gene. (Review) PMID: 22951388
    9. upregulation of miR-664, miR-485-3p, and miR-495 contributes to lower MAT1A expression in HCC, and enhanced tumorigenesis may provide potential targets for HCC therapy. PMID: 23241961
    10. Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A levels. PMID: 22807109
    11. we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular carcinoma. PMID: 22318685
    12. Human Dead-box protein 3 (DDX3X), a RNA helicase regulating RNA splicing, export, transcription and translation was down-regulated upon MAT1A expression. PMID: 22270009
    13. genetic variant MAT1A 3U1510 displayed a significant interaction with dietary n-3:n-6 polyunsaturated fatty acids ratio in determining plasma homocysteine PMID: 21185701
    14. Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity. PMID: 21813468
    15. Methylation of the MAT1A coding region can inhibit gene transcription. This represents a key mechanism for decreased MAT1A expression in hepatocellular carcinoma. PMID: 21678410
    16. Results show a rather high frequency of hypermethioninaemia due to MAT I/III deficiency (MAT1A dominant mutation) in the Galician neonatal population. PMID: 18500573
    17. MAT and tripolyphosphatase (PPPase) activities of 18 MAT1A variants, six of them novel, and none of them previously assayed for activity. With the exception of G69S and Y92H, all recombinant proteins showed impairment (usually severe) of MAT activity. PMID: 20675163
    18. expression of the MAT1A gene is mediated by C/EBP and is indirectly upregulated by T(3) in hepatoma cell lines PMID: 20146079
    19. MAT1A variants were strongly associated with hypertension and stroke; improving folate and vitamin B-6 status may decrease cardiovascular disease risk of only a subset of the population, depending on genotype. PMID: 20335551
    20. Mutations in the MAT1A gene are the most prevalent cause of isolated hypermethioninemia in Taiwanese. PMID: 15935930

    顯示更多

    收起更多

  • 相關疾病：
    Methionine adenosyltransferase deficiency (MATD)
  • 蛋白家族：
    AdoMet synthase family
  • 組織特異性：
    Expressed in liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6903

    OMIM: 250850

    KEGG: hsa:4143

    STRING: 9606.ENSP00000361280

    UniGene: Hs.282670



主站蜘蛛池模板： 国产亚洲精品资源在线26u| 亚洲中文字幕在线精品2021| 久久午夜无码鲁丝片直播午夜精品 | 先锋影音av最新资源| 色综合久久网| 国产9 9在线 | 中文| 新版天堂资源中文www连接| 国产欧美丝袜在线二区| 国产亚洲欧美在线专区| 美女裸体跪姿扒开屁股无内裤| 亚洲国产成人久久综合人| 久久天天躁狠狠躁夜夜2o2o| 一本一道av无码中文字幕﹣百度 | 亚洲中文字幕不卡无码| 18禁免费吃奶摸下激烈视频| 少妇系列之白嫩人妻| 久久久综合香蕉尹人综合网| 精品av中文字幕在线毛片| 亚洲午夜精品久久久久久人妖| 永久免费的av在线电影网无码 | 色婷婷我要去我去也| 国产av亚洲精品久久久久久小说 | 欧美性猛交xxxx富婆| 欧美人与动zozo在线播放| 丰满少妇大力进入| 色翁荡熄又大又硬又粗又视频图片 | 欧美日韩亚洲国产综合乱| 女人另类牲交zozozo| 妺妺窝人体色www在线小说| 国产制服丝袜亚洲高清| 在线观看无码av网址| 无码人妻精品一区二区| 四虎影视精品永久在线观看| 蜜臀少妇人妻在线| 亚洲人成电影网站色www| 国产成人无码免费视频在线| 老司机午夜精品视频资源| 亚洲色欲色欲大片www无码| 欧美日韩免费做爰大片人| 国产精品无码a∨果冻传媒| а√天堂8资源在线官网|