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  4. Recombinant Human Ribonuclease UK114 (HRSP12)

Recombinant Human Ribonuclease UK114 (HRSP12)

  • 中文名稱：
    人RIDA重組蛋白
  • 貨號：
    CSB-YP010744HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RIDA重組蛋白
  • 貨號：
    CSB-EP010744HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RIDA重組蛋白
  • 貨號：
    CSB-BP010744HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RIDA重組蛋白
  • 貨號：
    CSB-MP010744HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RIDA
  • Uniprot No.：
  • 別名：
    14.5 kDa translational inhibitor protein; 2-iminobutanoate/2-iminopropanoate deaminase; Heat responsive protein 12; Heat-responsive protein 12; Hrsp12; p14.5; Perchloric acid soluble protein; PSP; Reactive intermediate imine deaminase A homolog; Ribonuclease UK114; RIDA; Translational inhibitor p14.5; Translational inhibitor protein p14.5; UK114; UK114 antigen homolog; UK114_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-137
  • 氨基酸序列
    MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALK NMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSR IEIEAVAIQGPLTTASL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.; Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
  • 基因功能參考文獻：
    1. x-ray crystallography study of p14.5 PMID: 14997576
    2. analysis of ligand binding sites of protein p14.5 PMID: 16198412
  • 亞細胞定位：
    Cytoplasm. Nucleus. Peroxisome. Mitochondrion.
  • 蛋白家族：
    RutC family
  • 組織特異性：
    Expressed predominantly in liver and kidney. Lower levels in lung and brain.
  • 數據庫鏈接：

    HGNC: 16897

    OMIM: 602487

    KEGG: hsa:10247

    STRING: 9606.ENSP00000254878

    UniGene: Hs.18426



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