在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Rho guanine nucleotide exchange factor 4 (ARHGEF4)

  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 4(ARHGEF4)
  • 貨號:
    CSB-YP882083HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 4(ARHGEF4)
  • 貨號:
    CSB-EP882083HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 4(ARHGEF4)
  • 貨號:
    CSB-EP882083HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 4(ARHGEF4)
  • 貨號:
    CSB-BP882083HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Rho guanine nucleotide exchange factor 4(ARHGEF4)
  • 貨號:
    CSB-MP882083HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    ARHGEF4; KIAA1112Rho guanine nucleotide exchange factor 4; APC-stimulated guanine nucleotide exchange factor 1; Asef; Asef1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-690
  • 氨基酸序列
    MPWEEPAGEK PSCSHSQKAF HMEPAQKPCF TTDMVTWALL CISAETVRGE APSQPRGIPH RSPVSVDDLW LEKTQRKKLQ KQAHVERRLH IGAVHKDGVK CWRKTIITSP ESLNLPRRSH PLSQSAPTGL NHMGWPEHTP GTAMPDGALD TAVCADEVGS EEDLYDDLHS SSHHYSHPGG GGEQLAINEL ISDGSVVCAE ALWDHVTMDD QELGFKAGDV IEVMDATNRE WWWGRVADGE GWFPASFVRL RVNQDEPADD DAPLAGNSGA EDGGAEAQSS KDQMRTNVIN EILSTERDYI KHLRDICEGY VRQCRKRADM FSEEQLRTIF GNIEDIYRCQ KAFVKALEQR FNRERPHLSE LGACFLEHQA DFQIYSEYCN NHPNACVELS RLTKLSKYVY FFEACRLLQK MIDISLDGFL LTPVQKICKY PLQLAELLKY THPQHRDFKD VEAALHAMKN VAQLINERKR RLENIDKIAQ WQSSIEDWEG EDLLVRSSEL IYSGELTRVT QPQAKSQQRM FFLFDHQLIY CKKDLLRRDV LYYKGRLDMD GLEVVDLEDG KDRDLHVSIK NAFRLHRGAT GDSHLLCTRK PEQKQRWLKA FAREREQVQL DQETGFSITE LQRKQAMLNA SKQQVTGKPK AVGRPCYLTR QKHPALPSNR PQQQVLVLAE PRRKPSTFWH SISRLAPFRK
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
  • 基因功能參考文獻:
    1. Our results indicate a possible contribution of CNVs in LEPR, NEGR1, ARHGEF4, and CPXCR1 and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children. PMID: 28428959
    2. These data demonstrate, that in addition to microtubule-independent Tiam1 activation, HGF engages additional microtubule- and APC-dependent pathway of Asef activation. PMID: 25101856
    3. these results demonstrate potent anti-inflammatory effects by HGF and delineate a key role of Asef in the mediation of the HGF barrier protective and anti-inflammatory effects. PMID: 25539852
    4. Expression of Asef was associated with lower estimated glomerular filtration rate in kidney disease. PMID: 23941980
    5. Expression of ARHGEF4 (Rho guanine nucleotide exchange factor 4) is restricted to the brain and may regulate the actin cytoskeletal network, cell morphology and migration, and neuronal function PMID: 22543972
    6. structures thus elucidate the molecular mechanism of Asef recognition by APC PMID: 21788986
    7. Forced expression of Asef in vitro induced and maintained proliferation of haemaopoietic progenitor cells and co-operated with TEL-AML1 greatly to enhance proliferation and haemopoietic colony size PMID: 19628279
    8. Positive role of Tyr94 phosphorylation in EGF-induced Asef activation following the activation of Rac1. PMID: 18653540
    9. Asef and APC function downstream of HGF and PI3-kinase, and play critical roles in growth factor-mediated regulation of cell morphology and migration PMID: 19525225

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 3]: Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side.
  • 組織特異性:
    Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors.
  • 數據庫鏈接:

    HGNC: 684

    OMIM: 605216

    KEGG: hsa:50649

    STRING: 9606.ENSP00000316845

    UniGene: Hs.469935



主站蜘蛛池模板: 国产精品久久久久久久久久久久午衣片 | 免费无码又爽又刺激软件下载直播| 亚洲成av人片不卡无码| 香蕉午夜福利院| 欧美 日产 国产在线观看| 日韩在线看片免费人成视频播放| 精品久久久久久中文字幕人妻最新| 一区二区乱子伦在线播放| 亚洲欧美日韩中文播放| 亚洲va中文在线播放| 国产男女免费完整视频在线| 久久精品人人做人人爽| 狠狠97人人婷婷五月| 无码人妻丰满熟妇区毛片| 色综合亚洲一区二区小说| 特级毛片全部免费播放| 亚洲精品久久久久玩吗| 成人区人妻精品一区二区不卡视频| 18禁黄网站禁片无遮挡观看| 韩国三级无码hd中文字幕| 亚洲色欲色欲www在线观看| 中国大陆高清aⅴ毛片| 在线亚洲日产一区二区| 国产肉丝袜在线观看| 国产成人无码精品久久久露脸| 国产欧美精品aaaaaa片| 亚洲国产成人极品综合| 国产精品aⅴ视频在线播放| 国产精品亚洲二区在线观看 | 中文字幕无码免费不卡视频| 欧美精品黑人粗大破除| 亚洲精品中国国产嫩草影院美女 | 日韩日韩日韩日韩日韩| 无码av岛国片在线播放| 婷婷色五月开心五月| 东京热无码av一区二区| 内射毛片内射国产夫妻| 污18禁污色黄网站免费| 亚洲第一在线综合网站| 色五月激情五月| 亚洲精品国产av成拍色拍个|