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  4. Recombinant Human Rho guanine nucleotide exchange factor 15 (ARHGEF15), partial

Recombinant Human Rho guanine nucleotide exchange factor 15 (ARHGEF15), partial

  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 15(ARHGEF15) ,partial
  • 貨號(hào)：
    CSB-YP002045HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 15(ARHGEF15) ,partial
  • 貨號(hào)：
    CSB-EP002045HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 15(ARHGEF15) ,partial
  • 貨號(hào)：
    CSB-EP002045HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 15(ARHGEF15) ,partial
  • 貨號(hào)：
    CSB-BP002045HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 15(ARHGEF15) ,partial
  • 貨號(hào)：
    CSB-MP002045HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGEF15
  • Uniprot No.：
  • 別名：
    ARGEF15; ARHGEF15; ARHGF_HUMAN; E5; Ephexin-5; Ephexin5; FLJ13791; KIAA0915; MGC44868; Rho guanine exchange factor 15; Rho guanine nucleotide exchange factor (GEF) 15; Rho guanine nucleotide exchange factor 15; Vsm RhoGEF; Vsm-RhoGEF
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
  • 基因功能參考文獻(xiàn)：
    1. pathological elevation of Ephexin5 expression critically drives Abeta-induced memory impairment PMID: 28346227
    2. upregulation of ARHGEF15 contributes to the development of aggressive PDAC by increasing the growth and motility of the pancreatic cancer cells, thereby worsening the prognosis of these patients. PMID: 27145964
    3. Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility. PMID: 23029280
    4. This paper presents functional studies determined in rat, mouse, and human tissues and cell lines. PMID: 12775584
  • 亞細(xì)胞定位：
    Cell projection, dendrite.
  • 組織特異性：
    Expressed in the vascular smooth muscle of coronary artery.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15590

    OMIM: 608504

    KEGG: hsa:22899

    STRING: 9606.ENSP00000355026

    UniGene: Hs.443109



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