在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Reticulon-1 (RTN1), partial

Recombinant Human Reticulon-1 (RTN1), partial

  • 中文名稱：
    人RTN1重組蛋白
  • 貨號：
    CSB-YP619090HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RTN1重組蛋白
  • 貨號：
    CSB-EP619090HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RTN1重組蛋白
  • 貨號：
    CSB-EP619090HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RTN1重組蛋白
  • 貨號：
    CSB-BP619090HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RTN1重組蛋白
  • 貨號：
    CSB-MP619090HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    RTN1; NSP; Reticulon-1; Neuroendocrine-specific protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity.
  • 基因功能參考文獻：
    1. Data suggest that reticulon 1A (RTN1A) functions not only as an endoplasmic reticulum-shaping protein but also as a protein that promotes contacts between endoplasmic reticulum and mitochondria. PMID: 28760823
    2. Results suggest evidence of genetic association between common variants in RTN1 and end-stage kidney disease in African-Americans and European-Americans. PMID: 26496126
    3. RTN1A is a key mediator for proteinuria-induced tubular cell toxicity and renal fibrosis. PMID: 26739891
    4. RTN1A contributes to progression of kidney disease by inducing ER stress. PMID: 26227493
    5. MANF is a protein that interacts with RTN1-C PMID: 25543119
    6. RTN-1C involvement in the regulation of Endoplasmic reticulum-mitochondria cross-talk, defines a role for RTN-1C in maintaining the function of contacts between the two organelles. PMID: 25573430
    7. RTN1-C induces PDI redistribution in endoplasmic reticulum vesicles, and concomitantly modulates its activity by decreasing the levels of its S-nitrosylated form. PMID: 23559015
    8. In the present study a potential metal ion binding motif (HxE/D) at the C-terminal of the RTN1-C has been identified and its capability to bind metals investigated by UV-vis, CD, multidimensional NMR spectroscopy and biological assays. PMID: 22522967
    9. RTN-1C is able to specifically regulate gene expression, modulating transcript clusters which have been implicated in the onset of neurodegenerative disorders PMID: 20708685
    10. RTN1-A and RTN1-B share N-terminal 168 amino acid region, suggesting that the 168 amino acid region might play a role in regulating the endocytic process PMID: 14995077
    11. Data demonstrate that reticulon 1 interacts specifically with spastin. PMID: 16602018
    12. analyzed the endoplasmic reticulum (ER) localization signal of human RTN1-A. Mutant proteins lacking the first (39 residues) or second (36 residues) hydrophobic segment showed ER localization PMID: 17303085
    13. These data indicate that RTN-1C is able to modulate the cellular sensitivity to different apoptotic pathways representing a promising molecular target for new drug development. PMID: 17596210
    14. Nucleic acid binding of the RTN1-C C terminal region is reported with a view towards the functional role of a reticulon protein. PMID: 19140693
    15. RTN-1C protein binds to DNA and that its biological function is regulated by acetylation and is coupled to the inhibition of HDAC activity. PMID: 19668229

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 組織特異性：
    Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.
  • 數據庫鏈接：

    HGNC: 10467

    OMIM: 600865

    KEGG: hsa:6252

    STRING: 9606.ENSP00000267484

    UniGene: Hs.368626



主站蜘蛛池模板： 大学生高潮无套内谢视频| 狠狠色丁香久久综合婷婷| 国产国语亲子伦亲子| 麻豆 美女 丝袜 人妻 中文| 香蕉av福利精品导航| 亚洲va久久久噜噜噜久久男同| 国产精品嫩草99av在线| 丰满少妇被猛烈进av毛片| 国产在线精品视频免费观看| 性一交一乱一色一视频| 日韩人妻无码精品专区906188| 亚洲精品成人av在线观看爽翻天| 丰满熟女人妻一区二区三| 2018av天堂在线视频精品观看| 婷婷五月日韩av永久免费| 久久婷婷五月综合色奶水99啪| 国产精品涩涩涩视频网站| 爱性久久久久久久久| 国产在线欧美日韩精品一区 | 9lporm自拍视频区| 中文字幕人妻无码系列第三区| 色欲久久久天天天综合网精品| 国产精品美脚玉足脚交| 国产午夜福利不卡在线秋霞秋霞| 国产成人无码a区精油按摩| 色与欲影视天天看综合网| 久久69精品久久久久久hb| 精品人妻va出轨中文字幕| 久久人人爽天天玩人人妻精品 | 亚欧av无码乱码在线观看性色| 大肉大捧一进一出好爽视频| 97国产精品麻豆性色aⅴ人妻波| 天天av天天av天天透| 国产三级精品三级| 色翁荡息又大又硬又粗又爽| 免费看撕开奶罩揉吮奶头视频| 精品久久久中文字幕人妻| av天堂永久资源网| 日韩精品无码久久久久久| 无码国产成人午夜在线观看| 亚洲熟妇av乱码在线观看|