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  4. Recombinant Human Ras-related protein Rap-1b (RAP1B)

Recombinant Human Ras-related protein Rap-1b (RAP1B)

  • 中文名稱：
    人RAP1B重組蛋白
  • 貨號：
    CSB-YP019323HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RAP1B重組蛋白
  • 貨號：
    CSB-EP019323HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RAP1B重組蛋白
  • 貨號：
    CSB-EP019323HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RAP1B重組蛋白
  • 貨號：
    CSB-BP019323HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RAP1B重組蛋白
  • 貨號：
    CSB-MP019323HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    GTP-binding protein smg p21B; K-REV; OK/SW-cl.11; RAL1B; rap1b; RAP1B member of RAS oncogene family; RAP1B_HUMAN; Ras family small GTP binding protein RAP1B; RAS related protein RAP1B; Ras-related protein Rap-1b; Small GTP binding protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    1-181
  • 氨基酸序列
    MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS C
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
  • 基因功能參考文獻：
    1. Talin-F0 domain binds to Rap1b like canonical Rap1 effectors despite little sequence homology, and disruption of the binding strongly impairs integrin activation, cell adhesion, and cell spreading. PMID: 29170462
    2. Aberrant expression of lncRNA AFAP1-AS, a competing endogenous RNA of miR-181a, may involve in the onset and progression of Hirschsprung disease by augmenting the miR-181a target gene, RAP1B. PMID: 28924375
    3. In RCC tissues and renal carcinoma cells, miR-28-5p is expressed at a low level and RAP1B is expressed at a high level. miR-28-5p inhibits the tumorigenesis of RCC by directly downregulating RAP1B and influencing the activation of two MAP kinases in the MAPK signaling pathway, p38 and Erk1/2. PMID: 27729617
    4. describe the methods for expression and purification of the plexin cytoplasmic region in E. coli, and characterization of its GAP activity using a photometric assay. We also provide a protocol for measuring GAP activity of single-chain constructs with Rap covalently linked to the plexin cytoplasmic region PMID: 27787845
    5. Data show that RAP1B expression was up-regulated in esophageal squamous cell carcinoma (ESCC) clinical samples and RAP1B interacted with DVL2 and activated Wnt/beta-catenin signaling. PMID: 28119087
    6. The protein expression of RAP1B and HIF-1 alpha contributed to gastric cancer malignant behavior and poor prognosis. PMID: 26329876
    7. Cholera toxin and beta-adrenergic receptor activation phosphorylate Rap1B and inhibit its prenylation and membrane localization. PMID: 26209110
    8. Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. PMID: 25569036
    9. Adenosine signaling reduces prenylation and plasma membrane localization of Rap1B, resulting in enhanced tumor cell scattering and invasiveness. PMID: 23716715
    10. High concentrations of extracellular adenosine in the tumor microenvironment can chronically activate A2B receptors to suppress Rap1B prenylation and signaling at the cell membrane, resulting in reduced cell-cell contact and promoting cell scattering. PMID: 23716716
    11. TMZ as a standard chemotherapeutic agent for GBM inhibits the Rap1B expression and actin cytoskeleton remodeling to exert its cell killing by upregulating miR-181a/b/c/d subunits PMID: 24573637
    12. Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone. PMID: 24790136
    13. findings show Rap1b expression decreased significantly in tubules of renal biopsies from patients with diabetic nephropathy (DN); findings indicate Rap1b ameliorates tubular injury and slows progression of DN by modulation of mitochondrial dysfunction via C/EBP-beta-PGC-1alpha signaling PMID: 24353183
    14. Hepatitis B virus down-regulated miR-101-3p expression, which resulted in up-regulation of Rap1b, and down-regulation of miR-101-3p or up-regulation of Rap1b promoted proliferation and migration of hepatocellular carcinoma cells PMID: 24697700
    15. phosphorylation of CalDAG-GEFI is a critical mechanism by which PKA controls Rap1b-dependent platelet aggregation PMID: 23611601
    16. miR-139 decreases proliferation by directly targeting RAP1B PMID: 22642900
    17. miR-518b was down-regulated in esophageal squamous cell carcinoma tissues and correlated with metastasis and survival. Furthermore, Rap1b was revealed to be directly regulated by miR-518b PMID: 22958893
    18. Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton (integrin alpha(IIb)beta(3)) PMID: 11994301
    19. Data show that stimulation of a G(i)-dependent signaling pathway causes activation of Rap1B through the action of the PI3K product PtdIns(3,4,5)P(3) and that this process may contribute to potentiation of platelet aggregation. PMID: 12407113
    20. RAP1B is prominently expressed in the nucleus of squamous carcinomas. PMID: 13679863
    21. PAR-1 and PAR-4 signal Rap1B activation, the ability of thrombin to activate this GTPase independently of secreted ADP involves costimulation of both receptors as well as binding to GPIb-IX-V. PMID: 15078882
    22. TPO integrates G(i), but not G(q), stimulation, supports integrin alpha(IIb)beta(3) activation platelet aggregation independently of phospholipase C but requires PI3-kinase and Rap1B PMID: 15863506
    23. The RAP1B gene mutation is a rare event in myelodysplastic syndromes(MDS) bone marrow cells, in detecting RAP1B mutations, random mutagenesis was performed in RAP1B exons 2 and 3. PMID: 16118622
    24. Rap1b is an important element in integrin-dependent outside-in signaling during platelet adhesion and regulates the cross talk between adhesive receptors. PMID: 16357324
    25. These results demonstrate that Rap2b, but not the more abundant Rap1b, is associated to lipid rafts in human platelets. PMID: 18582561
    26. structure of Epac2 in complex with a cAMP analogue (Sp-cAMPS) and RAP1B by X-ray crystallography and single particle electron microscopy PMID: 18660803
    27. Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation. PMID: 18842593
    28. a mechanistic explanation for the differential effects of Rap1 phosphorylation by PKA on effector protein interaction PMID: 19651783

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  • 亞細胞定位：
    Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction.
  • 蛋白家族：
    Small GTPase superfamily, Ras family
  • 數據庫鏈接：

    HGNC: 9857

    OMIM: 179530

    KEGG: hsa:5908

    STRING: 9606.ENSP00000250559

    UniGene: Hs.369920



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