Recombinant Human Ras-related protein Rab-40A-like (RAB40AL)

中文名稱：

人RAB40AL重組蛋白
貨號：

CSB-YP019203HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人RAB40AL重組蛋白
貨號：

CSB-EP019203HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人RAB40AL重組蛋白
貨號：

CSB-EP019203HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RAB40AL重組蛋白
貨號：

CSB-BP019203HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人RAB40AL重組蛋白
貨號：

CSB-MP019203HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

RAB40AL
Uniprot No.：

P0C0E4
別名：

RAB40AL; RLGP; Ras-related protein Rab-40A-like; Ras-like GTPase
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區(qū)域：

1-278
氨基酸序列

MSAPGSPDQA YDFLLKFLLV GDRDVGKSEI LESLQDGTAE SPYSHLGGID YKTTTILLDG QRVKLKLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFEGMDRWIK KIEEHAPGVP KILVGNRLHL AFKRQVPREQ AQAYAERLGV TFFEVSPLCN FNIIESFTEL ARIVLLRHRL NWLGRPSKVL SLQDLCCRTI VSCTPVHLVD KLPLPIALRS HLKSFSMAKG LNARMMRGLS YSLTTSSTHK RSSLCKVKIV CPPQSPPKNC TRNSCKIS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
基因功能參考文獻：
1. Our findings are inconsistent with a causative effect of RAB40AL p.D59G on cognitive impairment combined with severe to profound bilateral hearing loss but indicate that p.D59G is a common genetic variation. PMID: 25370018
2. Data question the role of RAB40AL mutation as a disease-causing change and the involvement of RAB40AL in Martin-Probst syndrome. PMID: 25044830
3. We herein present an unrelated 20-year-old male with similar manifestations also with p.D59G in the RAB40AL gene, which supports the existence of this condition previously coined as Martin-Probst syndrome PMID: 24863632
4. This is the first study to show that mutation of RAB40AL is associated with a human disorder. PMID: 22581972
相關(guān)疾病：

Mental retardation, X-linked, syndromic, Martin-Probst type (MRXSMP)
亞細(xì)胞定位：

Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Mitochondrion.
蛋白家族：

Small GTPase superfamily, Rab family
組織特異性：

Expressed in brain, lung, heart, skeletal muscle, kidney and liver. Highest expression in brain. Expressed in fetal brain and kidney.
數(shù)據(jù)庫鏈接：

HGNC: 25410

OMIM: 300405

KEGG: hsa:282808

STRING: 9606.ENSP00000218249

UniGene: Hs.449517