在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ras-related protein Rab-21 (RAB21)

  • 中文名稱:
    人RAB21重組蛋白
  • 貨號:
    CSB-YP891733HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人RAB21重組蛋白
  • 貨號:
    CSB-EP891733HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人RAB21重組蛋白
  • 貨號:
    CSB-EP891733HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人RAB21重組蛋白
  • 貨號:
    CSB-BP891733HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人RAB21重組蛋白
  • 貨號:
    CSB-MP891733HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    RAB21
  • Uniprot No.:
  • 別名:
    KIAA0118; RAB 21; RAB21; RAB21; member RAS oncogene family; RAB21_HUMAN; Ras-related protein Rab-21
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-222
  • 氨基酸序列
    AAAGGGGGG AAAAGRAYSF KVVLLGEGCV GKTSLVLRYC ENKFNDKHIT TLQASFLTKK LNIGGKRVNL AIWDTAGQER FHALGPIYYR DSNGAILVYD ITDEDSFQKV KNWVKELRKM LGNEICLCIV GNKIDLEKER HVSIQEAESY AESVGAKHYH TSAKQNKGIE ELFLDLCKRM IETAQVDERA KGNGSSQPGT ARRGVQIIDD EPQAQTSGGG CC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Small GTPase involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10.
  • 基因功能參考文獻:
    1. Rab21 silencing can induce apoptosis and inhibit proliferation in human glioma cells. PMID: 29270202
    2. Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. PMID: 25648148
    3. High RAB21 expression is associated with glioma. PMID: 24477653
    4. Taken together, these data suggest that Rab21 plays a negative role in the EGF-mediated MAPK signaling pathway. Overexpression of Rab21 attenuated EGF-mediated mitogen-activated protein kinase (MAPK) signaling by inducing EGFR degradation. PMID: 22525675
    5. Rab21 (and Rab5) associate with the cytoplasmic domains of alpha-integrin chains, and their expression influences the endo/exocytic traffic of integrins. This function of Rab21 is dependent on its GTP/GDP cycle and proper membrane targeting PMID: 16754960
    6. Results show that targeted trafficking of integrins to and from the cleavage furrow is required for successful cytokinesis, and that this is regulated by Rab21. PMID: 18804435
    7. show that TI-VAMP interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp, a guanine nucleotide exchange factor of the small GTPase Rab21, through a specific domain herein called the interacting domain. PMID: 19745841

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Cell projection, neuron projection.
  • 蛋白家族:
    Small GTPase superfamily, Rab family
  • 組織特異性:
    Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expres
  • 數據庫鏈接:

    HGNC: 18263

    OMIM: 612398

    KEGG: hsa:23011

    STRING: 9606.ENSP00000261263

    UniGene: Hs.524590



主站蜘蛛池模板: 亚洲综合一区国产精品| 少妇熟女视频一区二区三区 | 人人妻人人爽日日人人| 欧美xxxx做受欧美88| 强行糟蹋人妻hd中文字| 蜜臀亚洲精品国产aⅴ综合第一| 午夜伦4480yy私人影院久久| 尤物精品国产第一福利网站| 国产无遮挡裸体免费视频在线观看 | 久久综合av免费观看| 一本之道高清无码视频| 国产人妻人伦精品1国产丝袜 | 亚洲中文字幕av不卡无码 | 精品人妻无码一区二区三区蜜桃一 | 国产亚洲精品综合一区| 中文字幕人成乱码熟女| 国产精品怡红院在线观看| 国产成人av一区二区三区无码| 久久精品亚洲中文字幕无码网站| 国产成人亚洲综合无码精品| 亚洲欧美日本久久综合网站| 真人一进一出120秒试看| 亚洲第一无码xxxxxx| 99久久国产综合精品swag| 99久久无码一区人妻a黑| 怡红院一区二区三区在线| 又硬又粗又大一区二区三区视频| 忘忧草日本在线www| 中文字幕 乱码 中文乱码视频 | 国产精品对白刺激久久久| 99久久久无码国产精品免费| 亚洲中文字幕不卡无码| 国精产品一区一区三区有限公司| 天天综合天天做天天综合| 久久久欧美精品激情| 亚洲欲色欲色xxxxx在线| 国产精品后入内射日本在线观看| 人妻少妇精品视频无码综合| 真人啪啪高潮喷水呻吟无遮挡| 亚洲中文无码av在线| 天堂mv在线mv免费mv香蕉|