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  4. Recombinant Human Ras association domain-containing protein 5 (RASSF5)

Recombinant Human Ras association domain-containing protein 5 (RASSF5)

  • 中文名稱：
    人RASSF5重組蛋白
  • 貨號：
    CSB-EP819906HU
  • 規格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Maxp 1; MAXP1; MGC10823; MGC17344; New ras effector 1; NORE 1; NORE1; NORE1A; NORE1B; Novel Ras effector 1; RAP1 Binding Protein; RAPL; Ras association (RalGDS/AF 6) domain family 5; Ras association (RalGDS/AF 6) domain family member 5; Ras association domain containing family protein 5; Ras association domain-containing protein 5; Ras effector like protein; RASF5_HUMAN; RASSF 3; RASSF 5; RASSF3; RASSF5; Regulator for cell adhesion and polarization enriched in lymphoid tissue; Regulator for cell adhesion and polarization enriched in lymphoid tissues; Tumor suppressor RASSF3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Isoform 2
  • 來源：
    E.coli
  • 分子量：
    57.4kDa
  • 表達區域：
    1-265aa
  • 氨基酸序列
    MTVDSSMSSGYCSLDEELEDCFFTAKTTFFRNAQSKHLSKNVCKPVEETQRPPTLQEIKQKIDSYNTREKNCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNLAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADRPLYLRLLAGPDTEVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKLEEALRESQGKPG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal GST-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis.
  • 基因功能參考文獻：
    1. Ubc9 is an essential regulator of ADAP where it is required for TCR-induced membrane recruitment of the small GTPase Rap1 and its effector protein RapL. PMID: 29127148
    2. Hepatitis C virus uses NS5B to specifically suppress NORE1A, facilitating viral replication and elevated Ras signaling. PMID: 28090674
    3. Our study demonstrated that miR-214 expression was elevated and RASSF5 was down regulated in oral cancer. Moreover, miR-214 suppressed KB cell apoptosis through down regulation of RASSF5 expression PMID: 28290615
    4. mCD40L-induced cell death mediated by NORE1A expression appeared to be independent of mCD40L-induced cell death mediated by sustained JNK activation since NORE1A inhibition did not affect JNK phosphorylation and vice versa PMID: 26986513
    5. Ras induces the formation of a complex between NORE1A and the phosphatase PP1A, promoting the activation of the Rb tumor suppressor by dephosphorylation PMID: 26677227
    6. Down-regulation of RASSF5A and RASSF5C expression is a tumor-specific phenomenon. PMID: 25420558
    7. RASSF5 expression is negatively correlated with distant metastasis of osteosarcoma, and RASSF5 may function as a tumor suppressor in OS cells through activation of the MST1/LATS1 pathway. PMID: 25109282
    8. NORE1A allows Ras to qualitatively modify p53 function to promote senescence. PMID: 25778922
    9. the inactivation of RASSF5A through CpG island 1 methylation may play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis, RASSF5A may be a functional tumor suppressor and may serve as a prognostic biomarker for ESCC. PMID: 25579665
    10. NORE1A has a role in Ras regulation of SCF(beta-TrCP) protein activity and specificity PMID: 25217643
    11. RASSF5 can act as an inhibitor or a potential positive regulator of Mst2, depending on whether it binds to Mst2 before or after activation-loop phosphorylation. PMID: 23972470
    12. Ubiquitin ligase Itch is a unique negative regulator of RASSF5. PMID: 23538446
    13. The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma. PMID: 22695170
    14. crystal of NORE1 diffracted to 2.7 A resolution and belonged to space group P6(1)22, with unit-cell parameters a = b = 73.041, c = 66.092 A, alpha = beta = 90, gamma = 120 degrees PMID: 22750872
    15. These findings indicate that the control of HIPK1 stability by Mdm2-NORE1 has a major effect on cell behaviour, and epigenetic inactivation of NORE1 enables adenocarcinoma formation in vivo through HIPK1 stabilization. PMID: 22173032
    16. NORE1A has activity that suppresses the centrosome amplification induced by HU and that NORE1A mRNA down-regulation is one of the common gene abnormalities in NSCLCs, both of which imply a key preventive role of NORE1A against the carcinogenesis of NSCLC. PMID: 20434789
    17. epigenetic inactivation of NORE1 due to aberrant promoter hypermethylation is a frequent event in colorectal tumorigenesis and might be implicated in the malignant progression of colorectal tumors PMID: 20969767
    18. a novel regulatory network composed of the tumor suppressor NORE1A, the mitotic kinase Aurora A, the small GTPase Ras, and the microtubule cytoskeleton. PMID: 20339001
    19. findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes. PMID: 20346707
    20. The present investigation provided evidence that Lck-mediated phosphorylation regulates the nucleocytoplasmic shuttling and cell growth control activities of RASSF5. PMID: 20064523
    21. Nore1 is a member of a family of Ras effector/tumor suppressors that includes RASSF1 PMID: 12676952
    22. the epigenetic alteration of NORE1A is confined to lung tumors with a wild-type K-ras: 88% (15 of 17) of the tumors with NORE1 hypermethylation did not harbor a K-ras mutation (P=0.008, Fisher's exact test) PMID: 15378027
    23. Rap1 activation contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL localizes PMID: 15569673
    24. results indicate that RASSF1A epigenetic changes are an early event in thyroid tumor pathogenesis and progression PMID: 15980887
    25. Suppression of NORE1A, a known Ras effector, in PAX8-PPARgamma fusion-carrying follicular thyroid cancer. PMID: 16352687
    26. association of NORE1A with cytoskeletal elements is essential for NORE1A-induced growth suppression and that the ERK pathway is a target for NORE1A growth-suppressive activities PMID: 16421102
    27. The candidate tumor suppressor gene NORE1B is epigenetically down-regulated in hepatocellular carcinoma. PMID: 16516329
    28. These findings suggest that endogenous Nore1B recruits active Ras to the APC-T cell interface and mediates the interaction between Ras and Carma1. PMID: 16520020
    29. The NORE1A gene was never found epigenetically methylated in hepatitic or non-hepatitic liver. PMID: 16606445
    30. Nuclear localization of RASSF5 is critical for its cell growth control activity. PMID: 17320110
    31. interaction surfaces in RAPL-Rap1 and RAPL-Rap2 complexes are different and that a single residue in the switch I region of Rap proteins (residue 39) contributes considerably to the different kinetics of these protein-protein interactions. PMID: 17716979
    32. nuclear export of NORE1A via nuclear export signal is involved in the NORE1A-mediated induction of apoptosis PMID: 18211824
    33. NORE1A promoter methylation is a rare event in neuroblastoma cells and primary tumors. Other mechanisms are likely to account for the frequent reduction of NORE1A mRNA expression. Also, antitumorigenic role of NORE1A in human neuroblastoma is evident. PMID: 18452173
    34. Study describes the crystal structure of Ras in complex with the Ras binding domain (RBD) of NORE1A; the contact area of NORE1A is extended as compared with other Ras effectors & provides a rationale for an exceptionally long lifetime of the complex. PMID: 18596699
    35. findings showed that only 4% of the glioma tumors revealed a methylated promoter for NORE1A PMID: 18616639
    36. Data show that degradation by calpains is a novel mechanism for downregulation of NORE1A and RASSF1A proteins and might be the mechanism allowing cancer cells to escape growth suppression. PMID: 19098985
    37. NORE1B suppresses replication and transformation of cells as effectively as RASSF1A and is a putative tumor suppressor gene. NORE1B interacts with RASSF1A and loss of one of these may lead to uncontrolled growth and transformation of hepatocytes. PMID: 19118008
    38. NORE1A activates p21(CIP1) via promoting p53 nuclear localization. PMID: 19435914

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
  • 組織特異性：
    Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
  • 數據庫鏈接：

    HGNC: 17609

    OMIM: 607020

    KEGG: hsa:83593

    STRING: 9606.ENSP00000347443

    UniGene: Hs.497579



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