在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human RNA demethylase ALKBH5 (ALKBH5)

Recombinant Human RNA demethylase ALKBH5 (ALKBH5)

  • 中文名稱：
    Recombinant Human RNA demethylase ALKBH5(ALKBH5)
  • 貨號：
    CSB-YP744062HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human RNA demethylase ALKBH5(ALKBH5)
  • 貨號：
    CSB-EP744062HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human RNA demethylase ALKBH5(ALKBH5)
  • 貨號：
    CSB-BP744062HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human RNA demethylase ALKBH5(ALKBH5)
  • 貨號：
    CSB-MP744062HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    ALKBH5; ABH5; OFOXD1RNA demethylase ALKBH5; EC 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-394
  • 氨基酸序列
    AAASGYTDL REKLKSMTSR DNYKAGSREA AAAAAAAVAA AAAAAAAAEP YPVSGAKRKY QEDSDPERSD YEEQQLQKEE EARKVKSGIR QMRLFSQDEC AKIEARIDEV VSRAEKGLYN EHTVDRAPLR NKYFFGEGYT YGAQLQKRGP GQERLYPPGD VDEIPEWVHQ LVIQKLVEHR VIPEGFVNSA VINDYQPGGC IVSHVDPIHI FERPIVSVSF FSDSALCFGC KFQFKPIRVS EPVLSLPVRR GSVTVLSGYA ADEITHCIRP QDIKERRAVI ILRKTRLDAP RLETKSLSSS VLPPSYASDR LSGNNRDPAL KPKRSHRKAD PDAAHRPRIL EMDKEENRRS VLLPTHRRRG SFSSENYWRK SYESSEDCSE AAGSPARKVK MRRH
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro). Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells.
  • 基因功能參考文獻：
    1. Overexpression of ALKBH5 in MIA-PaCa-2 and BxPC-3 cells, demonstrats that ALKBH5 could inhibit cell migration and invasion and ALKBH5 inhibits cell motility by demethylating and increasing expression of KCNK15- AS1. PMID: 30032148
    2. N(6)-Methyladenosine itself serves as a 'conformational marker', which induces different conformational outcomes in RNAs depending on sequence context. This critically impacts its interactions with several m6A-recognising proteins, including FTO and ALKBH5. PMID: 27156733
    3. ALKBH5 knockdown in breast cancer cells significantly decreased metastasis from breast to lungs in immunodeficient mice PMID: 27590511
    4. ALKBH5-FOXM1 pathway is critical for glioblastoma proliferation and tumorigenesis.ALKBH5 expression increases in glioblastoma stem-like cells and predicts poor survival in glioblastoma patients. PMID: 28344040
    5. HIF-dependent ALKBH5 expression mediates enrichment of BCSCs in the hypoxic tumor microenvironment PMID: 27001847
    6. The ALKBH5 gene may play a role in conferring risk of MDD in the Chinese population. PMID: 26047305
    7. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. PMID: 24778178
    8. Modelling substrate into the active site of ALKBH5 reveals conserved residues important for recognition and demethylation mechanisms. PMID: 24489119
    9. findings provide a structural basis for understanding the substrate recognition specificity of Alkbh5 and offer a foundation for selective drug design against AlkB members PMID: 24616105
    10. ALKBH5 is a RNA demethylase and its action strongly suggests that the reversible methyladenosine modification has fundamental and broad functions in mammalian cells. PMID: 23177736
    11. ALKBH5 may have a role in the regulation of cellular responses to hypoxia as a class of HIF-transcriptional target gene PMID: 21264265

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus speckle.
  • 蛋白家族：
    AlkB family
  • 組織特異性：
    Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.
  • 數據庫鏈接：

    HGNC: 25996

    OMIM: 613303

    KEGG: hsa:54890

    STRING: 9606.ENSP00000382091

    UniGene: Hs.744130



主站蜘蛛池模板： 久草热久草热线频97精品| 国产日产欧产精品精品ai| 亚洲精品tv久久久久久久久j| 午夜亚洲国产理论片中文飘花| 亚洲综合久久一本伊一区| 东京热无码av男人的天堂| 99蜜桃臀久久久欧美精品网站| 日韩av片无码一区二区三区| 高清国产在线拍揄自揄视频| 亚洲五月天综合| 免费的很黄很污的视频| 成年轻人电影免费无码| 在线亚洲97se亚洲综合在线| 久久精品国产丝袜人妻| 成人片黄网站色大片免费| 色欲久久人妻内射| 欧美精品18videosex性欧| 国产sm重味一区二区三区| 人妻互换 综合| 美女扒开奶罩露出奶头视频网站| 欧美特大特白屁股ass| 性视频播放免费视频| 亚洲中文字幕精品久久久久久动漫 | 印度女人狂野牲交| 久久久久久av无码免费网站下载| 精产国品一区二区三产区| 久久综合国产乱子伦精品免费| 国产精品一区二区av不卡| 99国产精品久久久久久久成人| 亚洲午夜无码久久久久小说| 精品久久久无码人妻中文字幕豆芽 | 无码抽搐高潮喷水流白浆| 又粗又硬又大又爽免费视频播放| 97碰碰碰免费公开在线视频| 大胸美女污污污www网站| 国产亚洲产品影市在线产品| 麻花豆传媒剧国产免费mv入口| 国产熟妇另类久久久久久| 国产极品久久久久极品| 天天色影网| 精品国产国语对白久久免费|