在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1)

  • 中文名稱:
    人PDP1重組蛋白
  • 貨號:
    CSB-YP878946HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PDP1重組蛋白
  • 貨號:
    CSB-EP878946HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PDP1重組蛋白
  • 貨號:
    CSB-EP878946HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PDP1重組蛋白
  • 貨號:
    CSB-BP878946HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PDP1重組蛋白
  • 貨號:
    CSB-MP878946HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    PDP1
  • Uniprot No.:
  • 別名:
    [Pyruvate dehydrogenase [acetyl transferring]] phosphatase 1; mitochondrial; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1; FLJ32517; Gm1024; MGC119646 ; mitochondrial; PDH; PDP 1; PDP; Pdp1; PDP1_HUMAN; PDPC 1; PDPC; PPM2C; Protein phosphatase 2C; protein phosphatase 2C; magnesium dependent; catalytic subunit; Pyruvate dehydrogenase (Lipoamide) phosphatase phosphatase; Pyruvate dehydrogenase phosphatase catalytic subunit 1; Pyruvate dehydrogenase phosphatase; catalytic subunit 1; RP23 203A12.1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    72-537
  • 氨基酸序列
    ASTPQKFYL TPPQVNSILK ANEYSFKVPE FDGKNVSSIL GFDSNQLPAN APIEDRRSAA TCLQTRGMLL GVFDGHAGCA CSQAVSERLF YYIAVSLLPH ETLLEIENAV ESGRALLPIL QWHKHPNDYF SKEASKLYFN SLRTYWQELI DLNTGESTDI DVKEALINAF KRLDNDISLE AQVGDPNSFL NYLVLRVAFS GATACVAHVD GVDLHVANTG DSRAMLGVQE EDGSWSAVTL SNDHNAQNER ELERLKLEHP KSEAKSVVKQ DRLLGLLMPF RAFGDVKFKW SIDLQKRVIE SGPDQLNDNE YTKFIPPNYH TPPYLTAEPE VTYHRLRPQD KFLVLATDGL WETMHRQDVV RIVGEYLTGM HHQQPIAVGG YKVTLGQMHG LLTERRTKMS SVFEDQNAAT HLIRHAVGNN EFGTVDHERL SKMLSLPEEL ARMYRDDITI IVVQFNSHVV GAYQNQE
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
  • 基因功能參考文獻:
    1. High PDH expression is associated with glucose intolerance. PMID: 28148899
    2. YB-1 phosphorylation at Ser-102 is an important prerequisite for CCL5 promoter activation during macrophage differentiation PMID: 24962578
    3. the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3 PMID: 24486017
    4. Although 7 days of bed rest induced whole body glucose intolerance, exercise-induced PDH regulation in skeletal muscle was not changed, suggesting that exercise-induced PDH regulation in skeletal muscle is maintained in glucose-intolerant individuals. PMID: 21680880
    5. catalytic subunit of PDP1 crystals belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c = 216.1 A. PMID: 20208177
    6. pyruvate dehydrogenase phosphatase PDP1 is down-regulated in circulating lymphocytes of obese subjects because it is poorly sensitive to magnesium/calcium; this defect is attenuated when plasma insulin is greatly enhanced PMID: 15897476
    7. Lower accumulation of free ADP and AMP after the FAT-adapt trial may be responsible for the decreased glycogenolysis and PDH activation during sprinting. PMID: 16188909
    8. Functional characterization of the bovine counterpart. PMID: 8396421
    9. Functional characterization of the rat counterpart. PMID: 9651365
    10. In cultured skin fibroblasts from three patients with congenital lactic acidemia due to a defect in activation of the pyruvate dehydrogenase complex, the PDP-activity was significantly reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts. PMID: 1327585
    11. In postmortem tissue samples, from male child with metabolic acidosis, PDK normally reduced PDH-activity in ATP-presence. Addition of Ca++ and Mg++ did not restored PDH-activity. The defect was attributed to a markedly reduced PDP-activity. PMID: 172850

    顯示更多

    收起更多

  • 相關疾病:
    Pyruvate dehydrogenase phosphatase deficiency (PDP deficiency)
  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    PP2C family
  • 數據庫鏈接:

    HGNC: 9279

    OMIM: 605993

    KEGG: hsa:54704

    STRING: 9606.ENSP00000379503

    UniGene: Hs.22265



主站蜘蛛池模板: 国产 | 久你欧洲野花视频欧洲1| 欧美人与动性xxxxbbbb | 少妇被爽到高潮在线观看| 国产成人精品日本亚洲成熟| 玩弄白嫩少妇xxxxx性| 秋霞国产午夜伦午夜福利片 | 国产免国产免费| 又粗又紧又湿又爽的视频| 天天爽夜夜爽人人爽88| 日本亚洲欧洲无免费码在线| 自愉自愉产区二十四区| 久久综合少妇11p| 国产高清-国产av| 亚洲熟妇av一区| 欧美日韩精品一区二区在线播放| 国产精品久久久久久久久岛| 久久国产午夜精品理论片| 久久伊人av综合影院| 亚洲日韩乱码久久久久久| 色婷婷五月综合久久| 少妇久久久久久人妻无码| 亚洲一区二区三区偷拍女厕| 无码一区二区三区在线观看| 天天澡天天揉揉av无码| 亚洲乱码日产精品bd在观看| 绝顶丰满少妇av无码| 久久人妻无码中文字幕第一| 乱色国内精品视频在线| 妺妺窝人体色www看人体| 国产精品国产三级国产a| 中文字幕aav| 国产麻传媒精品国产av| 国产特级毛片aaaaaa毛片| 亚洲免费人成视频观看| 日本一区不卡高清更新二区 | 精品人妻无码一区二区三区换脸| 97久章草在线视频播放| 亚洲精品久久久久一区二区| 国产精品人人爽人人做我的可爱| 人妻系列av无码专区| 中文字幕在线影视|