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  4. Recombinant Human Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)

Recombinant Human Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)

  • 中文名稱：
    人PYCR1重組蛋白
  • 貨號(hào)：
    CSB-YP019115HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PYCR1重組蛋白
  • 貨號(hào)：
    CSB-EP019115HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PYCR1重組蛋白
  • 貨號(hào)：
    CSB-BP019115HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PYCR1重組蛋白
  • 貨號(hào)：
    CSB-MP019115HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PYCR1
  • Uniprot No.：
  • 別名：
    PYCR1; Pyrroline-5-carboxylate reductase 1; mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    2-319
  • 氨基酸序列
    SVGFIGAGQ LAFALAKGFT AAGVLAAHKI MASSPDMDLA TVSALRKMGV KLTPHNKETV QHSDVLFLAV KPHIIPFILD EIGADIEDRH IVVSCAAGVT ISSIEKKLSA FRPAPRVIRC MTNTPVVVRE GATVYATGTH AQVEDGRLME QLLSSVGFCT EVEEDLIDAV TGLSGSGPAY AFTALDALAD GGVKMGLPRR LAVRLGAQAL LGAAKMLLHS EQHPGQLKDN VSSPGGATIH ALHVLESGGF RSLLINAVEA SCIRTRELQS MADQEQVSPA AIKKTILDKV KLDSPAGTAL SPSGHTKLLP RSLAPAGKD
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.
  • 基因功能參考文獻(xiàn)：
    1. we firmly establish biallelic mutations in POLR3A as the genetic cause of a recognizable, neonatal, Wiedemann-Rautenstrauch-like progeroid syndrome. Thus, we suggest that POLR3A mutations are causal for a portion of under-diagnosed early-onset segmental progeroid syndromes PMID: 30450527
    2. Results indicate that single-nucleotide polymorphism (SNP)-derived mutations, R119G and G206W, enhance the rigidity of pyrroline-5-carboxylate reductase (P5CR) structure. PMID: 27677826
    3. these findings revealed that the mRNA and protein PYCR1 levels were significantly related to the poor outcome in either ER-negative or ER-positive breast cancer. PYCR1 could serve as a prognostic biomarker, therapeutic target and predictive biomarker for breast cancers. PMID: 28379297
    4. PYCR1 forms a concentration-dependent decamer in solution, consistent with the pentamer-of-dimers assembly seen crystallographically PMID: 28258219
    5. Authors found that PYCR1 was highly expressed in prostate cancer tissues and then knocked down PYCR1 in PCa cell lines (DU145, PC-3 and LNCap) via lentivirus-mediated gene delivery and analyzed its biological function. PMID: 28078560
    6. experimental results indicate the R119G mutation could be an involving pathomechanism for Autosomal recessive cutis laxa . PMID: 28194412
    7. Silencing of both PYCR1 and PYCR2 completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress. PMID: 26733354
    8. confirming that indeed PYCR1 generates L-pipecolic acid from Delta(1)-piperideine-6-carboxylate PMID: 24431009
    9. our current study presents the second largest group of patients with PYCR1-related ARCL and expands the clinical and genetic spectrum. PMID: 24035636
    10. Identification of two new mutations in the PYCR1 gene in patients with autosomal recessive cutis laxa, type 2. PMID: 23531708
    11. Data suggest that DJ-1 and PYCR1 are on the same pathway of anti-oxidative stress protection of the cells. PMID: 23743200
    12. The findings presented here suggest a mutation screening of PYCR1 and cardiovascular survey in patients with De Barsy syndrome (DBS). PMID: 22052856
    13. Mutation analysis revealed the presence of disease-causing variants in PYCR1, including a novel deletion of the entire PYCR1 gene in one family, and in each of the other patients the homozygous missense mutations. PMID: 21487760
    14. A novel mutation in PYCR1 causes an autosomal recessive cutis laxa with premature aging features in a family. PMID: 21567914
    15. The phenotype caused by PYCR1 mutations corresponds to geroderma osteodysplasticum rather than ARCL2B. PMID: 21204221
    16. Mutagenesis and kinetic studies reveal the pivotal roles of the dinucleotide-binding Rossmann motif and residue Glu221 in the human enzyme Pyrroline-5-carboxylate reductase(P5CR). PMID: 16730026
    17. In Autosomal-recessive cutis laxa type 2, a single nucleotide change leads to a missense mutation adjacent to a splice junction in the gene encoding PYCR1. PMID: 19576563
    18. Mutations in PYCR1 cause cutis laxa with progeroid features. PMID: 19648921

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  • 相關(guān)疾?。?/div>
    Cutis laxa, autosomal recessive, 2B (ARCL2B); Cutis laxa, autosomal recessive, 3B (ARCL3B)
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Pyrroline-5-carboxylate reductase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9721

    OMIM: 179035

    KEGG: hsa:5831

    STRING: 9606.ENSP00000328858

    UniGene: Hs.163451



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