在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Putative RNA-binding protein 3 (RBM3)

Recombinant Human Putative RNA-binding protein 3 (RBM3)

  • 中文名稱：
    人RBM3重組蛋白
  • 貨號：
    CSB-BP019420HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RBM3重組蛋白
  • 貨號：
    CSB-EP019420HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RBM3重組蛋白
  • 貨號：
    CSB-MP019420HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    RBM3
  • Uniprot No.：
  • 別名：
    2600016C11Rik; IS1 RNPL; MGC105811; MGC118410; OTTHUMP00000025800; OTTHUMP00000025802; OTTMUSP00000019634; OTTMUSP00000019635; OTTMUSP00000019636; Putative RNA binding protein 3; Putative RNA-binding protein 3; Rbm3; RBM3_HUMAN; RNA binding motif (RNP1; RRM) protein 3; RNA binding motif protein 3; RNA-binding motif protein 3; RNA-binding protein 3; RNPL; RP23-27I6.7
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length
  • 表達區域：
    1-157aa
  • 氨基酸序列
    MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASVAMRAMNGESLDGRQIRVDHAGKSARGTRGGGFGAHGRGRSYSRGGGDQGYGSGRYYDSRPGGYGYGYGRSRDYNGRNQGGYDRYSGGNYRDNYDN
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation.
  • 基因功能參考文獻：
    1. Results showed that high RBM3 expression in gastric cancer is mainly found in intestinal-type of Lauren grade and is associated with longer overall survival time. PMID: 29263314
    2. Overexpression of RBM3 rescued SH-SY5Y cells from UV-induced apoptosis. PMID: 28831692
    3. RBM3 is overexpressed in bipolar disorder patients responding to lithium treatment compared to non-responders. PMID: 28616776
    4. Loss of RBM3 expression is an unfavourable prognostic marker in colorectal cancers (CRCs), and is linked to right-sided tumour localization. PMID: 25922889
    5. High RBM3 expression is an independent predictor of prolonged survival in metastatic colorectal cancer patients. PMID: 28800641
    6. Results show that RBM3 overexpression results in increased stemness in colon cancer cells, and inactivation of GSK3 through phosphorylation, thereby enhancing b-catenin signaling activity the colorectal cancer cells. PMID: 26331352
    7. Low RBM3 expression is associated with colon Cancer. PMID: 28373441
    8. Studies showed RBM3 as one of the important cold shock protein with critical roles in rapid cell adaption to the alterations of the environmental stress. Also, RBM3 plays an important role in neuroprotection, anti-apoptotic functions, cell proliferation as well as its function as proto-oncogene.[review] PMID: 27364162
    9. The results indicate the existence of a negative feedback loop that regulates fever via reduced RBM3 levels and increased expression of miR-142-5p and miR-143. PMID: 26825461
    10. Low RBM3 immunoexpression is associated with urothelial carcinoma of the bladder. PMID: 26577765
    11. RBM3 may be a potential biomarker for treatment stratification in patients with metastatic non-seminomatous germ cell tumours. PMID: 25811459
    12. High RBM3 expression is an independent prognostic marker in prostate cancer. PMID: 24380696
    13. The data suggest that the overexpression of RBM3 may serve as an important molecular mechanism underlying astrocytic carcinogenesis. PMID: 23673116
    14. A novel role of RBM3 in linking stress-regulated RNA splicing to tumorigenesis. PMID: 23667174
    15. Loss of RBM3 expression is associated with more aggressive tumors and poorer prognosis of urothelial bladder cancer. Findings may indicate that loss of RBM3 expression results in a phenotype more prone to metastatic spread than local aggressiveness. PMID: 23565664
    16. the inverse association and prognostic impact of MCM3 and RBM3 expression indicate a possible interaction of these proteins in melanoma progression PMID: 22805320
    17. high tumor-specific nuclear expression of RBM3 is an independent predictor of good prognosis in colorectal cancer PMID: 21956899
    18. high nuclear expression of RBM3 in prostate cancer is associated with a prolonged time to disease progression PMID: 21955582
    19. RBM3 is down-regulated in metastatic melanoma and high nuclear RBM3 expression in the primary tumour is an independent marker of a prolonged overal survival. PMID: 21777469
    20. RBM3 may be a useful prognostic and treatment predictive marker in epithelial ovarian cancer. PMID: 20727170
    21. RBM3 is a critical factor providing cellular survival advantages in an adverse microenvironment presumably by restoring translation efficacy PMID: 19770690
    22. Nuclear RBM3 is an independent favorable prognostic factor in breast cancer, and seems to have a specific role in estrogen receptor-positive tumors. PMID: 19734850
    23. RBM3 and CIRP are adaptatively expressed in response to hypoxia by a mechanism that involves neither HIF-1 nor mitochondria PMID: 15075239
    24. From these results, it seems that the X-chromosome, through its RBM genes, plays a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer. PMID: 16552754
    25. the RNA stabilizing and translation regulatory protein RBM3 is a novel proto-oncogene that induces transformation when overexpressed and is essential for cells to progress through mitosis. PMID: 18427544
    26. pharmacological modulation of RBM3 and CIRBP may represent novel therapeutic approaches for prostate cancer. PMID: 19277990

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Cell projection, dendrite.
  • 數據庫鏈接：

    HGNC: 9900

    OMIM: 300027

    KEGG: hsa:5935

    STRING: 9606.ENSP00000365946

    UniGene: Hs.301404



主站蜘蛛池模板： 国产熟睡乱子伦午夜视频麻豆| 超碰曰口干天天种夜夜爽| 综合自拍亚洲综合图区欧美 | 久久亚洲国产成人精品无码区| 国产成人精品午夜福利| 午夜无码大尺度福利视频| 国内丰满熟女出轨videos| 国产成人8x视频网站入口| 狂野欧美性猛交免费视频| 亚洲午夜无码久久久久蜜臀av| 午夜国产成人片在线播放| 国产欧美日韩va另类在线播放| 国产av无码专区国产乱码| 精品麻豆一区二区三区乱码| 亚洲欧洲综合有码无码| 成人丝袜激情一区二区| 18禁女裸乳扒开免费视频| 成人国产精品无码网站| 2021久久最新国产精品| 午夜免费啪视频观看视频 | 成人免费b2b网站大全在线| 国色天香成人一区二区| 亚洲国产精品一区二区美利坚| 国产免国产免费| 99久热re在线精品视频| 人妻av乱片av出轨av| 国产午夜精品一区理论片飘花| 人人玩人人添人人澡超碰偷拍 | 色欲综合久久躁天天躁蜜桃| av无码中出一区二区三区| 欧美成人片在线观看| 国产精品自在拍在线播放| 女人与公拘交酡全过程| 天天躁日日躁狠狠躁性色avq| 国产精品久久久久久妇女| 国产无限次数成版人视频在线 | 秋霞国产精品一区二区| 人妻少妇久久久久久97人妻| 国模裸体无码xxxx视频| 国语对白做受xxxxx在| 少妇又紧又深又湿又爽视频|