在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Puromycin-sensitive aminopeptidase (NPEPPS), partial

In Stock
  • 中文名稱:
    人NPEPPS重組蛋白
  • 貨號:
    CSB-BP015980HU
  • 規格:
    ¥3168
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    AAP-S; Aminopeptidase puromycin sensitive; Cytosol alanyl aminopeptidase; Metalloprotease 100; Metalloprotease MP100; MP 100; MP100 ; Npepps; Psa; PSA_HUMAN; Puromycin sensitive aminopeptidase; Puromycin-sensitive aminopeptidase
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Baculovirus
  • 分子量:
    54.9
  • 表達區域:
    53-504aa
  • 氨基酸序列
    RLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
  • 基因功能參考文獻:
    1. cytosolic peptidases(puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) ) may be involved in colorectal carcinogenesis PMID: 26078706
    2. Studies indicate the critical role of M1 aminopeptidases ERAP1, ERAP2 and NPEPPS in immune-mediated diseases. PMID: 25142031
    3. MiR-614 inhibited cell invasion and proliferationa targeting PSA in lung cancer cells, PGCL3 PMID: 25342037
    4. Elevation of NPEPPS activity blocks accumulation of hyperphosphorylated TAU protein and slows down the progression of Alzheimer's disease. PMID: 21320871
    5. findings show that by promoting autophagic protein clearance, PSA helps protect against accumulation of aggregation-prone proteins and proteotoxicity PMID: 20829225
    6. attenuated proteolysis of FTDP-17 mutant tau may be explained by increased phosphorylation levels, resulting in resistance to proteolysis. PMID: 20377816
    7. ApPS Y394F exhibited a 3.3-fold lower affinity for RB-3014, a transition state inhibitor, indicating that Tyr394 is involved in transition state stabilization PMID: 14706550
    8. PSA gene was downregulated in PC-3 cells that were treated with CoCl(2). PSA is involved in the proliferation, migration, and invasion of PC-3 cells, which are important determinants of metastasis, via a mechanism that involves MMP-9 modulation. PMID: 19494703

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族:
    Peptidase M1 family
  • 組織特異性:
    Detected in liver, epithelium of renal tubules, epithelium of small and large intestine, gastric epithelial cells, and alveoli of the lung (at protein level).
  • 數據庫鏈接:

    HGNC: 7900

    OMIM: 606793

    KEGG: hsa:9520

    STRING: 9606.ENSP00000320324

    UniGene: Hs.443837



主站蜘蛛池模板: 天躁夜夜躁狼狠躁| 131美女爱做视频| 一本色综合网久久| 无修无码h里番在线播放网站| 婷婷丁香六月激情综合在线人| 国产永久免费观看的黄网站| 成人av一本不卡二卡 | 欧洲女人性开放免费网站| 亚洲va欧美va国产va综合| 亚洲欧美色中文字幕在线| 美女视频黄是免费| 免费国产a国产片高清| 99热成人精品热久久6网站| 欧美另类又黄又爽的a片| 狠日狠干日日射| 真人二十三式性视频(动)| 一 级做人爱全视频在线看| 亚洲国产欧美在线成人| 欧美亚洲另类 丝袜综合网| 日韩在线 | 中文| 亚洲精品国产第一综合99久久| 亂倫近親相姦中文字幕| 女人爽到高潮潮喷18禁网站| 久久久av男人的天堂| 无码熟妇人妻av在线网站| 99久久亚洲精品日本无码| 国产人妻精品一区二区三区| 2020国产欧洲精品网站| 女人被躁到高潮免费视频软件 | 国产乱妇无码大片在线观看| 国产sm调教折磨视频| 无码专区 丝袜美腿 制服师生| 亚洲最大激情中文字幕| 欧美性黑人极品hd| 成 人影片 免费观看| 国产精品午夜福利不卡| 欧美性色老妇人| 国产精品videossex国产高清| 国产成人无码区免费内射一片色欲| 久久www免费人成人片| 日本少妇寂寞少妇aaa|