Recombinant Human Proteolipid protein 2 (PLP2 A4)

中文名稱：
貨號：

CSB-YP882617HU
規格：
來源：

Yeast
其他：

中文名稱：
貨號：

CSB-EP882617HU
規格：
來源：

E.coli
其他：

中文名稱：
貨號：

CSB-EP882617HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：
貨號：

CSB-BP882617HU
規格：
來源：

Baculovirus
其他：

中文名稱：
貨號：

CSB-MP882617HU
規格：
來源：

Mammalian cell
其他：

產品詳情
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產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PLP2
Uniprot No.：

Q04941
別名：

Proteolipid protein 2; Differentiation-dependent protein A4; Intestinal membrane A4 protein; PLP2 A4
種屬：

Homo sapiens (Human)
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role in cell differentiation in the intestinal epithelium.
基因功能參考文獻：
1. PLP2 specifically binds to phosphatidylinositol 3 kinase to activate the protein kinase B pathway to enhance cell proliferation, adhesion, and invasion in melanoma cells. PMID: 26287415
2. miR-664 negatively regulates PLP2 and promotes proliferation and invasion of T-ALL cell lines. Thus, miR-664 may represent a potential therapeutic target for T-ALL intervention. PMID: 25735976
3. PLP2 and RAB5C are binding partners of TPD52. PMID: 24604726
4. This work ascribes a critical function to PLP2 for viral ligase activity and underlines the power of non-lethal haploid genetic screens in human cells to identify the genes involved in pathogen manipulation of the host immune system. PMID: 24278019
5. PLP2/A4 has a role in the chemotactic processes via CCR1 PMID: 15474493
6. PLP2 is expressed abundantly in the pyramidal cells of hippocampus and granular cells of the cerebellum in the brains of a cohort of males with probable X-linked mental retardation. PMID: 17416750
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亞細胞定位：

Membrane; Multi-pass membrane protein.
組織特異性：

Enriched in colonic mucosa. The expression of A4 follows a gradient along the crypto-villus axis with the most abundant message occurring in the lower half of the crypt.
數據庫鏈接：

HGNC: 9087

OMIM: 300112

KEGG: hsa:5355

STRING: 9606.ENSP00000365505

UniGene: Hs.77422