在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein prune homolog (PRUNE)

  • 中文名稱:
    人PRUNE1重組蛋白
  • 貨號:
    CSB-EP771430HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    PRUNE1
  • Uniprot No.:
  • 別名:
    DRES-17; DRES17; Drosophila-related expressed sequence 17; hPrune; HTcD37; Protein prune homolog; PRUNE; Prune homolog; PRUNE like protein; PRUNE_HUMAN; TcD37 homolog
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Isoform 6
  • 來源:
    E.coli
  • 分子量:
    22.5kDa
  • 表達區域:
    1-168aa
  • 氨基酸序列
    MLRKDQKTIYRQGVKVAISAIYMDLEICEVLERSHSPPLKLTPASSTHPNLHAYLQGNTQVSRKKLLPLLQEALSAYFDSMKIPSGQPETADVSREQVDKELDRASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization.
  • 基因功能參考文獻:
    1. PRUNE is crucial for normal brain development and mutated in microcephaly with neurodevelopmental impairment. PMID: 28334956
    2. These results further delineate a new PRUNE1-related syndrome, and highlight the importance of periodic data re-annotation in individuals who remain without a diagnosis after undergoing genome-wide testing. PMID: 28211990
    3. h-Prune expression is necessary for cancer cell motility and EMT and is associated with liver and lung metastasis in colorectal cancer cells. h-Prune could be a new prognostic marker and molecular target for CRLM. PMID: 27037526
    4. Together these studies define PRUNE as a molecule fundamental for normal human cortical development and define cellular and clinical consequences associated with PRUNE mutation PMID: 28334956
    5. h-prune is frequently expressed in anaplastic thyroid cancer cells and lymph nodes metastasis, and promotes migration and invasion of anaplastic thyroid cancer cells and metastasis in an anaplastic thyroid cancer model. PMID: 27109060
    6. Authors assessed h-Prune levels in peripheral blood of lung cancer patients using ELISA assay, showing that h-Prune is an early diagnostic marker for lung cancer. PMID: 25026278
    7. Data indicate that the D388A and D422A mutant h-Prune proteins interact weakly with Nm23-H1. PMID: 23448979
    8. Increased amplification of PRUNE is associated with T4 breast carcinoma. PMID: 20735841
    9. prune has a role in breast neoplasm aggressiveness PMID: 15671547
    10. GSK-3 and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness. PMID: 16428445
    11. Prune is composed of two independent active sites and two interaction sites for the assembly of oligomeric signalling complexes PMID: 17655525

    顯示更多

    收起更多

  • 相關疾病:
    Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA)
  • 亞細胞定位:
    Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
  • 蛋白家族:
    PPase class C family, Prune subfamily
  • 組織特異性:
    Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
  • 數據庫鏈接:

    HGNC: 13420

    OMIM: 617413

    KEGG: hsa:58497

    STRING: 9606.ENSP00000271620

    UniGene: Hs.78524



主站蜘蛛池模板: 7777色鬼xxxx欧美色妇| 99久久免费国产精品| 中文字幕av伊人av无码av狼人| 国产三级在线观看播放| 无码国产精品一区二区免费式影视| 日韩精品毛片无码一区到三区| 女人裸露免费视频无遮挡网站 | 热99re久久精品天堂| 亚洲色爱免费观看视频| 亚洲国产精品久久久久婷婷老年| 日本妇人成熟免费| 国产精品无码av在线一区| 色欲综合久久中文字幕网| 国产又大又硬又粗| 日韩精品久久久久久久电影蜜臀 | 又黄又爽又无遮挡免费的网站| 人妻少妇精品专区性色av| 天堂va视频一区二区| 久久免费看少妇高潮v片特黄| 国产午夜福利精品一区二区三区 | 韩产日产国产欧产| 国产亚洲精品第一综合另类灬| 人间精品视频在线播放| 亚洲 小说 欧美 激情 另类| 午夜片神马影院福利| 国产a线视频播放| 日本二区三区欧美亚洲国| 性欧美大胆免费播放| 成人亚洲欧美一区二区三区| 婷婷色怡春院| 男人的天堂在线视频| 岛国片人妻三上悠亚| 欧洲熟妇色xxxxx欧美| 国产9 9在线 | 欧洲| 无码专区aaaaaa免费视频| 亚洲国产精品日本无码网站| 日本特黄aaaaaa大片| 80s国产成年女人毛片| 久久精品无码一区二区app | 免费网站看sm调教视频| 亚洲乱码中文字幕在线|