在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein naked cuticle homolog 2 (NKD2)

  • 中文名稱:
    人NKD2重組蛋白
  • 貨號:
    CSB-YP822162HU
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NKD2重組蛋白
  • 貨號:
    CSB-EP822162HU
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NKD2重組蛋白
  • 貨號:
    CSB-EP822162HU-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NKD2重組蛋白
  • 貨號:
    CSB-BP822162HU
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NKD2重組蛋白
  • 貨號:
    CSB-MP822162HU
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    hNkd2; Naked 2; Naked-2; nkd2; NKD2_HUMAN; Protein naked cuticle homolog 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達(dá)區(qū)域:
    2-451
  • 氨基酸序列
    GKLQSKHAA AARKRRESPE GDSFVASAYA SGRKGAEEAE RRARDKQELP NGDPKEGPFR EDQCPLQVAL PAEKAEGREH PGQLLSADDG ERAANREGPR GPGGQRLNID ALQCDVSVEE DDRQEWTFTL YDFDNCGKVT REDMSSLMHT IYEVVDASVN HSSGSSKTLR VKLTVSPEPS SKRKEGPPAG QDREPTRCRM EGELAEEPRV ADRRLSAHVR RPSTDPQPCS ERGPYCVDEN TERRNHYLDL AGIENYTSRF GPGSPPVQAK QEPQGRASHL QARSRSQEPD THAVHHRRSQ VLVEHVVPAS EPAARALDTQ PRPKGPEKQF LKSPKGSGKP PGVPASSKSG KAFSYYLPAV LPPQAPQDGH HLPQPPPPPY GHKRYRQKGR EGHSPLKAPH AQPATVEHEV VRDLPPTPAG EGYAVPVIQR HEHHHHHEHH HHHHHHHFHP S
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

相關(guān)產(chǎn)品

靶點詳情

  • 功能:
    Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.
  • 基因功能參考文獻(xiàn):
    1. ZFAS1 over-expression confers an oncogenic function in gastric cancer and this function is partly dependent on repressing KLF2 and NKD2 PMID: 27246976
    2. NKD2 is frequently methylated in human esophageal cancer, and the expression of NKD2 is regulated by promoter region methylation. NKD2 suppresses esophageal cancer progression by inhibiting Wnt signaling both in vitro and in vivo. PMID: 27374455
    3. NKD2 is the key molecular marker to study the progression of osteosarcoma development, and it may be used for better prognosis of the disease in early stage PMID: 27424978
    4. curcumin significantly inhibited the proliferation of colorectal cancer cells and upregulated the expression of NKD2 in SW620 colorectal cancer cells. PMID: 26985708
    5. NKD2 regulates osteosarcoma cell proliferation and apoptosis by inhibiting the Wnt signaling.MiR-130b targets NKD2 and regulates the Wnt signaling to promote proliferation and inhibit apoptosis of osteosarcoma cells. PMID: 26902120
    6. NKD2 is frequently methylated in human breast cancer, and the expression of NKD2 is regulated by promoter region methylation. PMID: 26124080
    7. NKD2 methylation is associated with cell differentiation, TNM stage and distant metastasis significantly (all P < 0.05), and the overall survival time is longer in NKD2 unmethylated group compared to NKD2 methylated group (P < 0.05). PMID: 26396173
    8. NKD2 antagonizes Wnt signaling: myristoylated NKD2 interacts with Dvl-1 at the plasma membrane, and this interaction leads to their mutual ubiquitin-mediated proteasomal degradation. PMID: 20177058
    9. NKD2 represents a candidate target of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease. PMID: 16752383
    10. Naked2 acts as a cargo recognition and targeting (CaRT) protein to ensure proper delivery, tethering, and fusion of TGF-alpha-containing vesicles to a distinct region at the basolateral surface of polarized epithelial cells. PMID: 17553928
    11. identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells PMID: 18757723

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane. Cytoplasm. Cytoplasmic vesicle.
  • 蛋白家族:
    NKD family
  • 組織特異性:
    Expressed in kidney, lung, pancreas and spleen.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17046

    OMIM: 607852

    KEGG: hsa:85409

    STRING: 9606.ENSP00000296849

    UniGene: Hs.240951



主站蜘蛛池模板: 亚洲在av极品无码天堂手机版| 人妻色综合网站| 国产后入清纯学生妹| 中文天堂最新版在线www| 亚洲日韩国产中文其他| 无码国产69精品久久久久网站| 亚洲日韩乱码久久久久久| 久久亚洲精品ab无码播放| 性色av一二三天美传媒| 欧美日本免费一区二区三区| 成品人视频ww入口| 久久香蕉综合色一综合色88 | 国产精品白丝av网站| 在线精品自偷自拍无码| 色婷婷av久久久久久久| 色多多www视频在线观看免费| 亚洲超碰无码色中文字幕97| 国产精品视频一区二区三区不卡 | 精品无人国产偷自产在线| 亚洲熟妇久久精品| 亚洲a∨国产av综合av网站| 东京热无码国产精品| 亚洲第一无码精品立川理惠| 免费国产黄网站在线观看视频| 精品av中文字幕在线毛片| 免费无码国产欧美久久18| 精品少妇人妻av一区二区三区| 亚洲成a∨人片在无码2023| 偷拍农村老熟妇xxxxx7视频| 偷偷色噜狠狠狠狠的777米奇| 日韩人妻无码一区二区三区综合部| 久久免费视频精品在线| √天堂资源在线中文8在线最新版| av无码精品一区二区三区宅噜噜| 国产成人综合95精品视频| 婷婷成人小说综合专区| 中文无码av一区二区三区| 国产一区二区在线影院| 亚洲最大无码av网站观看| 在线天堂免费观看.www| 一边摸一边抽搐一进一出视频|