在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein mono-ADP-ribosyltransferase PARP3 (PARP3)

  • 中文名稱:
    人PARP3重組蛋白
  • 貨號:
    CSB-MP017467HU
  • 規格:
    ¥1908
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    ADP-ribosyltransferase diphtheria toxin-like 3;ARTD3;DNA ADP-ribosyltransferase PARP3;IRT1;NAD+;ADPRT-3;Poly [ADP-ribose] polymerase 3;PARP-3;hPARP-3;Poly[ADP-ribose] synthase 3;pADPRT-3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 分子量:
    90.4 kDa
  • 表達區域:
    1-533aa
  • 氨基酸序列
    MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKRIIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWGRVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLLEVHL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal hFc1-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Cooperates with the XRCC5-XRCC6 (Ku80-Ku70) heterodimer to limit end-resection thereby promoting accurate NHEJ. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRCC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'- or 3'-terminal phosphate residues in DNA containing multiple strand breaks. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA /AID on the chromatin.
  • 基因功能參考文獻:
    1. These data identify PARP3 as a molecular sensor of nicked nucleosomes. PMID: 27530147
    2. PARP3 controls of TGFbeta-induced epithelial mesenchymal transformation and acquisition of stem-like cell features by stimulation transglutaminase 2/SNAI1 signaling. PMID: 27579892
    3. Data indicate that PARP3, a DNA damage-activated ADP-ribosyltransferase, can mono-ADP-ribosylate double-stranded DNA ends. PMID: 29054115
    4. In a process of single-strand DNA repair, PARP3 mono-ADP-ribosylates nucleosomal histone H2B. PMID: 27716488
    5. we found that PARP3 interacted with FoxM1 to enhance its transcriptional activity and conferred glioblastoma cell radioresistance. Thus, our data suggest that PARP3 could be a therapeutic target to overcome radioresistance in glioblastoma PMID: 26040766
    6. Identification of ADP-ribosylation sites in PARP3 and the determination of the extent ofpoly(ADP-ribosyl)ated residues in this protein was performed. PMID: 25800440
    7. MiR-630 reduced apoptosis by downregulating several apoptotic modulators, PARP3, DDIT4, and EP300. PMID: 25255219
    8. In some cancer cells, repression of PARP3 could be responsible for an increased telomerase activity. PMID: 24528514
    9. PARP3 likely facilitates the recruitment of Ku80 to double strand breaks to antagonize DNA end resection but facilitate Ku-mediated accurate classical non-homologous end-joining. PMID: 24598253
    10. PARP3 gene occupancy in the human neuroblastoma cell line SK-N-SH occurs preferentially with developmental genes regulating cell fate specification, tissue patterning, craniofacial development and neurogenesis. PMID: 21264220
    11. PARP3 is a critical player in the stabilization of the mitotic spindle and in telomere integrity by associating and regulating the mitotic components NuMA and tankyrase 1. PMID: 21270334
    12. PARP-3 has a role in chromosomal DNA double-strand break repair. PMID: 21211721
    13. the interaction between PARP-1 and PARP-3 is unrelated to DNA single-strand break repair PMID: 20064938
    14. PARP-3 is a nuclear protein involved in transcriptional silencing and in the cellular response to DNA damage PMID: 16924674

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 組織特異性:
    Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
  • 數據庫鏈接:

    HGNC: 273

    OMIM: 607726

    KEGG: hsa:10039

    STRING: 9606.ENSP00000381740

    UniGene: Hs.271742



主站蜘蛛池模板: 色777狠狠狠综合| 中文字幕在线影视| 强行征服邻居人妻淑敏| 国产成人啪精品午夜网站a片免费| 色在线 | 国产| 国模冰莲极品自慰人体| 人妻少妇偷人精品无码| 午夜在线a亚洲v天堂网2018| 最新国产久免费视频在线观看| 亚洲国产精品自在拍在线播放蜜臀 | 无码精品人妻一区二区三区人妻斩| 午夜亚洲www湿好大| 国产亚洲欧美日韩精品一区二区 | 国产精品久久久久高潮| 午夜理理伦电影a片无码| 中文在线а天堂中文在线新版| 亚洲人成无码www久久久| 熟女少妇人妻黑人sirbao| 亚洲欧美日产综合在线| 99久久精品费精品国产一区二区| 国产精品欧美久久久久久日本一道| 国产精品国色综合久久| 免费国产白丝喷水娇喘视频| 久久久久人妻精品区一三寸| 日韩人妻中文无码一区二区三区 | 精品国产午夜福利精品推荐| 成人性生交大免费看| 曰本女人与公拘交酡| 欧美黑人又粗又硬xxxxx喷水| 97精品免费公开在线视频| 午夜少妇性影院私人影院在线| 久久久久国色av免费看| 国产成人精品综合久久久久| 五月丁香啪啪激情综合色九色| 日本少妇寂寞少妇aaa| 性欧美欧美巨大69| 国产真实乱对白精彩| 捆绑白丝粉色jk震动捧喷白浆| 美女网站免费福利视频| 国产av一区最新精品| 日本熟日本熟妇在线视频|