在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Protein kinase C delta-binding protein (PRKCDBP)

Recombinant Human Protein kinase C delta-binding protein (PRKCDBP)

  • 中文名稱：
    Recombinant Human Protein kinase C delta-binding protein(PRKCDBP)
  • 貨號：
    CSB-YP842624HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Protein kinase C delta-binding protein(PRKCDBP)
  • 貨號：
    CSB-EP842624HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Protein kinase C delta-binding protein(PRKCDBP)
  • 貨號：
    CSB-EP842624HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Protein kinase C delta-binding protein(PRKCDBP)
  • 貨號：
    CSB-BP842624HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Protein kinase C delta-binding protein(PRKCDBP)
  • 貨號：
    CSB-MP842624HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CAVIN3
  • Uniprot No.：
  • 別名：
    Cavin 3; Cavin-3; CAVIN3; hSRBC; MGC20400; PRDBP_HUMAN; Prkcdbp; Protein kinase C delta binding protein; Protein kinase C delta-binding protein; Sdr related gene product that binds to c kinase; Serum deprivation response factor related gene product that binds to C kinase; Serum deprivation response factor-related gene product that binds to C-kinase; SRBC
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-261
  • 氨基酸序列
    MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ GGLAGSVRRI QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV RRAAQVQRLE ANHGLLVARG KLHVLLFKEE GEVPASAFQK APEPLGPADQ SELGPEQLEA EVGESSDEEP VESRAQRLRR TGLQKVQSLR RALSGRKGPA APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT EEDPGRPGAA EEALLQMESV A
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2.
  • 基因功能參考文獻：
    1. PRKCDBP variants may be risk factors of major depressive disorder. PMID: 27721187
    2. Rather than forming a single coat complex containing the three cavin family members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, cavin2 and cavin3. PMID: 24473072
    3. cavin3 is recruited to the caveolae coat by cavin1 to interact with caveolin1 and regulate the duration time of caveolae at the plasma membrane. PMID: 25588833
    4. in vivo consequences of cavin-3 knockout are increased lactate production and cachexia PMID: 24069528
    5. These results demonstrate that mucosal expression of PRKCDBP correlated strongly with TNF-alpha expression in UC patients and that infliximab therapy resulted in profound reductions in both PRKCDBP and TNF-alpha. PMID: 25052149
    6. we found loss at 11p15 to be a marker for triple-negative breast cancer and breast cancer brain metastases and PRKCDBP to be a potential target gene in this locus. PMID: 23118876
    7. individuals with the variant homozygous CC genotype of PRKCDBP rs1051992 were at higher risk for developing endometrial cancer, but this genotype was a favorable prognostic factor once cancer was present PMID: 23020606
    8. The cavin family protein Polymerase 1 and transcript release factor, SRBC and serum deprivation response protein were down regulated in breast cancer cell lines and breast tumor tissue. PMID: 21913217
    9. Data indicate that PRKCDBP expression was hardly detectable in 29 of 80 (36%) primary tumors and 11 of 19 (58%) cell lines. PMID: 21980136
    10. Our data demonstrate that epigenetic inactivation of hSRBC due to aberrant promoter hypermethylation is a common event and might be implicated in human ovarian tumorigenesis. PMID: 20423276
    11. Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4. PMID: 19679565
    12. hSRBC is a candidate tumor suppressor gene involved in lung cancer pathogenesis, where expression is frequently inactivated by methylation and other mechanisms PMID: 15940253
    13. hSRBC is a novel tumor suppressor whose epigenetic inactivation contributes to the malignant progression of gastric tumors, in part, through attenuated p53 response to stresses. PMID: 18059034
    14. Results suggest that SRBC (sdr-related gene product that binds to c-kinase) and two other family members [PTRF (Pol I and transcription release factor) and SDPR] function as caveolin adapter molecules that regulate caveolae function. PMID: 19262564
    15. Human SRBC is located within the 11p15.5-p15.4 tumor suppressor region and is inactivated in breast and lung cancers. PMID: 11691816

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Membrane, caveola. Cytoplasm, cytosol.
  • 蛋白家族：
    CAVIN family
  • 組織特異性：
    Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Strongly expressed in mammary and epithelial cells.
  • 數據庫鏈接：

    HGNC: 9400

    KEGG: hsa:112464

    STRING: 9606.ENSP00000307292

    UniGene: Hs.434044



主站蜘蛛池模板： 99精品视频一区在线观看| 国产成人无码网站| 天堂网www在线资源中文| 日本人又黄又爽又色的视频| 精品亚洲卡一卡2卡三卡乱码| 韩国三级中文字幕hd| 国产精品毛片一区二区| 亚洲欧美色αv在线影视| 男女做爰猛烈啪啪吃奶伸舌头下载 | 欧美激情精品久久久久久| 人妻丰满熟妇av无码片| 国产肉丝袜在线观看| 风流少妇又紧又爽又丰满| 国产精品岛国久久久久| 国产毛片不卡野外视频| 亚洲人成色77777在线观看大战| 久久久久国产a免费观看rela| 成人乱人乱一区二区三区| 99久久免费国产精品| 亚洲欧洲日韩综合久久| 黑森林福利视频导航| 亚洲无线看天堂av| 婷婷综合久久狠狠色99h| 67194熟妇在线观看线路1| 最爽无遮挡行房视频| 天堂va欧美va亚洲va好看va| 日韩人妻ol丝袜av一二区| 亚洲精品国产一区二区精华液| 亚洲无线看天堂av| 久久超碰极品视觉盛宴| 各种少妇正面bbw撒尿| 日本无卡码高清免费v| 日韩无套内射高潮| 五月婷婷久久草丁香| 亚洲码国产精品高潮在线| 亚洲韩国日本高清一区| 日韩乱码人妻无码中文视频| 韩国乱码伦视频免费| 免费人成网站在线观看不卡| 成人无码一区二区三区网站| 熟女人妻aⅴ一区二区三区60路|