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  4. Recombinant Human Protein bicaudal C homolog 1 (BICC1), partial

Recombinant Human Protein bicaudal C homolog 1 (BICC1), partial

  • 中文名稱：
    Recombinant Human Protein bicaudal C homolog 1(BICC1) ,partial
  • 貨號：
    CSB-YP872503HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Protein bicaudal C homolog 1(BICC1) ,partial
  • 貨號：
    CSB-EP872503HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Protein bicaudal C homolog 1(BICC1) ,partial
  • 貨號：
    CSB-EP872503HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Protein bicaudal C homolog 1(BICC1) ,partial
  • 貨號：
    CSB-BP872503HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Protein bicaudal C homolog 1(BICC1) ,partial
  • 貨號：
    CSB-MP872503HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    BICC1
  • Uniprot No.：
  • 別名：
    Bic-C; Bicaudal C homolog 1 (Drosophila); Bicc1; BICC1_HUMAN; CYSRD; Protein bicaudal C homolog 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
  • 基因功能參考文獻：
    1. The authors demonstrate that OFD1 cooperates with the mRNA binding protein Bicc1 to functionally control the protein synthesis machinery at the centrosome where also the PIC and eIF4F components were shown to localize in mammalian cells. PMID: 28450740
    2. genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population. PMID: 29044055
    3. Suggest allelic changes in the regulation of the BICC1 gene in amygdala neurones may contribute to mood disorders. PMID: 26440730
    4. Results provide some support for the involvement of BICC1 and PCLO in late-life depressive disorders and preliminary evidence that these genetic variants may also influence brain structural volumes PMID: 26391493
    5. findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior PMID: 25178406
    6. identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and suggest that it does so by regulating Pkd2 transcript levels PMID: 24789909
    7. Polymorphisms in intron 2 of BICC1 are associated with its expression and bone mineral density (BMD) PMID: 24789909
    8. The minor T-allele of BICC1 has a protective role against major depressive disorder and its known structural and functional brain changes. PMID: 22910460
    9. The nonsense mutation identified in BICC1 and associated with cystic renal dysplasia results in a complete loss of Wnt inhibitory activity. The point mutation in the SAM domain results in a 22% loss of activity. PMID: 21922595

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  • 相關疾病：
    Renal dysplasia, cystic (CYSRD)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    BicC family
  • 數據庫鏈接：

    HGNC: 19351

    OMIM: 601331

    KEGG: hsa:80114

    STRING: 9606.ENSP00000362993

    UniGene: Hs.100261



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