Recombinant Human Protein Wnt-6 (WNT6)

中文名稱：
貨號：

CSB-YP026140HU
規格：
來源：

Yeast
其他：

中文名稱：
貨號：

CSB-EP026140HU
規格：
來源：

E.coli
其他：

中文名稱：
貨號：

CSB-EP026140HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：
貨號：

CSB-BP026140HU
規格：
來源：

Baculovirus
其他：

中文名稱：
貨號：

CSB-MP026140HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

WNT6
Uniprot No.：

Q9Y6F9
別名：

Protein Wnt-6 WNT6
種屬：

Homo sapiens (Human)
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
基因功能參考文獻：
1. WNT6 may be a diagnostic and prognostic marker in osteosarcoma PMID: 30431574
2. our results support the concept that WNT6 may play a role in tumor progression PMID: 26617869
3. WNT6 activates the JNK signaling pathway in HDPCs, leading to migration and differentiation. PMID: 24935540
4. analysis of missense mutation in WNT6 in couples with unexplained recurrent miscarriage PMID: 25750203
5. WNT6 and Cav1 are upregulated by chemotherapeutics and enhance the resistance of GC cells to anthracycline drugs PMID: 22370641
6. The WNT6 rs6747776 homozygous minor allele (CC) was associated with increased risk of colorectal adenoma. PMID: 21547848
7. Wnt6 plays an important role in tooth development by promoting human dental papilla cell differentiation, without significant effects on cell proliferation. PMID: 20113781
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Wnt family
組織特異性：

Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level).
數據庫鏈接：

HGNC: 12785

OMIM: 604663

KEGG: hsa:7475

STRING: 9606.ENSP00000233948

UniGene: Hs.29764