在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Protein Wnt-16 (WNT16)

Recombinant Human Protein Wnt-16 (WNT16)

  • 中文名稱：
    人WNT16重組蛋白
  • 貨號：
    CSB-YP883369HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人WNT16重組蛋白
  • 貨號：
    CSB-EP883369HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人WNT16重組蛋白
  • 貨號：
    CSB-EP883369HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人WNT16重組蛋白
  • 貨號：
    CSB-BP883369HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人WNT16重組蛋白
  • 貨號：
    CSB-MP883369HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Protein Wnt 16 precursor; Protein Wnt-16; Wingless type MMTV integration site family member 16; WNT16; WNT16_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    30-365
  • 氨基酸序列
    N WMWLGIASFG VPEKLGCANL PLNSRQKELC KRKPYLLPSI REGARLGIQE CGSQFRHERW NCMITAAATT APMGASPLFG YELSSGTKET AFIYAVMAAG LVHSVTRSCS AGNMTECSCD TTLQNGGSAS EGWHWGGCSD DVQYGMWFSR KFLDFPIGNT TGKENKVLLA MNLHNNEAGR QAVAKLMSVD CRCHGVSGSC AVKTCWKTMS SFEKIGHLLK DKYENSIQIS DKTKRKMRRR EKDQRKIPIH KDDLLYVNKS PNYCVEDKKL GIPGTQGREC NRTSEGADGC NLLCCGRGYN THVVRHVERC ECKFIWCCYV RCRRCESMTD VHTCK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
  • 基因功能參考文獻：
    1. there was a significant difference in the genotypic frequencies of rs2707466 between hypertrophic and atrophic hip OA in males, with overrepresentation of G alleles in the hypertrophic phenotype. An association in the same direction was observed between these alleles and the type of knee OA, with G alleles being more common in the hypertrophic than in atrophic knee phenotypes PMID: 28766055
    2. WNT16B recognizes cancer cell surface receptors including frizzled (FZD) 3/4/6, a process enhanced by SFRP2, coordinated by the co-receptor LRP6 but subject to abrogation by DKK1. PMID: 26751775
    3. PRKX, WNT3 and WNT16 genes, belonging to the WNT signaling pathway, are involved in the tumorigenic process of nodular basal cell carcinoma PMID: 27630294
    4. ThE findingS suggests that WNT16 might be an important genetic factor in determining peak bone mass acquisition. PMID: 26510844
    5. Although in vitro studies demonstrated no differences in expressions of wild-type and mutant forms of IDUA and WNT16B proteins, in silico analyses predicts that WNT16 rs2707466 directly abolishes a phosphorylation site, which could cause a deleterious effect on WNT16 protein. PMID: 26256109
    6. MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16 PMID: 26100275
    7. Data indicate that WNT16 is critical for positive regulation of both cortical and trabecular bone mass and structure. WNT16-TG mice exhibited significantly higher whole-body areal bone mineral density and bone mineral content. PMID: 26584014
    8. ALL cells expressing WNT16 are sensitive to endoplasmic reticulum stress, and show enhanced killing after addition of chloroquine. PMID: 26254351
    9. loss of endogenous WNT16 results specifically in cortical bone loss, whereas overexpression of WNT16 surprisingly increases mainly trabecular bone mass. PMID: 26627248
    10. Describe TGFbeta-Wnt16-Notch signaling conduit in the chondrocyte-like transformation of VSMCs and identify endogenous TGFbeta activity in MGP-null VSMCs as a critical mediator of chondrogenesis. PMID: 25614285
    11. variants at WNT16 were more strongly related to upper limb-bone mineral density, than to bone mineral density at the other sites. PMID: 24945404
    12. Osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility. PMID: 25306233
    13. Increased translation of WNT16 can thus lead to an increased inhibitory action of WNT16 on canonical WNT signaling. PMID: 24185276
    14. Common missense polymorphisms of the WNT16 gene are associated with bone mineral density at the hip, calcaneal ultrasound and the buckling ratio of the femoral neck, as well as with hip fractures in individuals under 80 years of age. PMID: 23417354
    15. Estrogen/progesterone treatment of mature myometrial cells induced expression of WNT11 and WNT16, which remained constitutively elevated in leiomyoma tissues. PMID: 24082114
    16. results suggest synergistic effects of WNT16a insertion and the at-risk 'T' allele of TCF7L2 (rs7903146) for elevating the expression of TCF7L2 in human pancreas which may affect the regulation of downstream target genes involved in the development of T2D PMID: 23617586
    17. Analyses of femoral neck BMD also supported association with SNPs in WNT16 and ESR1/C6orf97 PMID: 23074152
    18. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. PMID: 22863786
    19. these findings postulate that the WNT16/C7orf58 locus contains complex patterns of genetic variation, which play an important role in peak bone mass accrual and may likely impact BMD determination at later life. PMID: 22792070
    20. These results suggest a critical role of Wnt 16 signaling pathway on cortical bone thickness and bone strength determination as well as fracture susceptibility. PMID: 22792071
    21. Results demonstrated significant up-regulation of WNT-3, WNT-4, WNT-5B, WNT-7B, WNT-9A, WNT-10A, and WNT-16B in patients with CLL compared to normal subjects. PMID: 19863181
    22. study identified WNT16B as a new marker of senescence that regulates p53 activity and the PI3K/AKT pathway and is necessary for the onset of replicative senescence PMID: 19951988
    23. genomic analysis of conserved sequences between human, rat, and zebrafish WNT16 PMID: 15756456
    24. Targeted-Wnt16b inhibition leads to apoptotic cell death, and Wnt16b mediates its effect through canonical Wnt pathway involving dishevelled-2, beta-catenin and survivin; Wnt16 plays an important role in leukemogenesis. PMID: 16007226
    25. Targeted-E2A-PBX1 inhibition leads to reduced expression of the EB-1 and Wnt16b genes; aberrant expression of these genes may be a key step in leukemogenesis in t(1;19)-positive pre-B leukemia. PMID: 16769578
    26. Wnt16 does not activate canonical Wnt signaling in E2A-PBX1-positive cells. Instead, beta-catenin is involved in N-cadherin-dependent adherence junctions PMID: 19101069

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Wnt family
  • 組織特異性：
    Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas.
  • 數據庫鏈接：

    HGNC: 16267

    OMIM: 606267

    KEGG: hsa:51384

    STRING: 9606.ENSP00000222462

    UniGene: Hs.272375



主站蜘蛛池模板： 亚洲精品国产自在现线看| 国内精品伊人久久久久av影院| 太深太粗太爽太猛了视频免费观看| 亚洲精品国产精品乱码不卡√| 国产av熟女一区二区三区| 人妻少妇精品视频一区二区三区| 高清粉嫩无套内谢国语播放| 国产八十老太另类| 黄页网站视频免费大全| 人妻夜夜添夜夜无码av | 国产情侣久久久久aⅴ免费| 51视频国产精品一区二区| 137裸交肉体摄影| 国产午夜理论不卡在线观看| 激情综合婷婷色五月蜜桃 | 性色av一二三天美传媒| 人妻无码久久一区二区三区免费| 国产又黄又爽又猛免费视频播放| 欧美成人一区二免费视频| 亚洲香蕉aⅴ视频在线播放| 久久久久欧美精品观看| 国产成人精品一区二区三区| 荡女精品导航| 宅男宅女精品国产av天堂| 2023国产精品一卡2卡三卡4卡 | 久久人妻无码中文字幕| 亚洲无人区午夜福利码高清完整版| 久久99精品久久久久蜜芽| 亚洲天堂男人影院| 丰满岳乱妇在线观看中字| 天天天天噜在线视频| 美女视频黄频大全免费| 黑人糟蹋人妻hd中文字幕| 亚洲精品国产品国语原创| 亚洲国产成人精品无码区在线| 国产精品久久久久久久久ktv| 好爽毛片一区二区三区四| 曰韩精品无码一区二区视频| 国产萌白酱喷水视频在线观看| 欧美老人巨大xxxx做受视频 | 精品久久久久久久中文字幕|