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  4. Recombinant Human Protein QIL1 (QIL1)

Recombinant Human Protein QIL1 (QIL1)

  • 中文名稱：
    人MIC13重組蛋白
  • 貨號：
    CSB-YP716854HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MIC13重組蛋白
  • 貨號：
    CSB-EP716854HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MIC13重組蛋白
  • 貨號：
    CSB-EP716854HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MIC13重組蛋白
  • 貨號：
    CSB-BP716854HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MIC13重組蛋白
  • 貨號：
    CSB-MP716854HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MIC13
  • Uniprot No.：
  • 別名：
    Chromosome 19 open reading frame 70; P117; Protein P117; Protein QIL1; Qil1; QIL1_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-118
  • 氨基酸序列
    MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSQAA LQKAGEVVPP AMYQFSQYVC QQTGLQIPQL PAPPKIYFPI RDSWNAGIMT VMSALSVAPS KAREYSKEGW EYVKARTK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex.
  • 基因功能參考文獻：
    1. Taken together, these data provide the first evidence of altered mitochondrial contact site assembly linked with a human mitochondrial disease and confirm a central role for QIL1 in stable mitochondrial contact site complex formation. PMID: 27623147
    2. MIC13 has a fundamental role in crista junction formation and that assembly of respiratory chain supercomplexes is independent of mitochondrial cristae shape. PMID: 27479602
    3. Mitochondrial hepato-encephalopathy patients were found to be homozygous for the p.(Gly15Glufs*75) variant in the QIL1 . QIL1 deficiency is associated with disassembly of the MICOS complex, aberration of cristae morphology and mitochondrial respiratory dysfunction. PMID: 27485409
    4. we identified QIL1 (C19orf70) as a novel conserved MICOS subunit. PMID: 25997101
  • 亞細胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族：
    MICOS complex subunit Mic13 family
  • 數據庫鏈接：

    HGNC: 33702

    OMIM: 616658

    KEGG: hsa:125988

    STRING: 9606.ENSP00000309561

    UniGene: Hs.356626



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