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  4. Recombinant Human Protein Jade-1 (PHF17), partial

Recombinant Human Protein Jade-1 (PHF17), partial

  • 中文名稱：
    人JADE1重組蛋白
  • 貨號：
    CSB-YP743563HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人JADE1重組蛋白
  • 貨號：
    CSB-EP743563HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人JADE1重組蛋白
  • 貨號：
    CSB-EP743563HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人JADE1重組蛋白
  • 貨號：
    CSB-BP743563HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人JADE1重組蛋白
  • 貨號：
    CSB-MP743563HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    JADE1
  • Uniprot No.：
  • 別名：
    FLJ22479; Gene for apoptosis and differentiation in epithelia; Jade family PHD finger 1; JADE1 ; JADE1_HUMAN; KIAA1807 ; OTTHUMP00000219842; OTTHUMP00000219934; OTTHUMP00000219935; OTTHUMP00000219936; PHD finger protein 17; PHD protein Jade 1; Phf17; Protein Jade 1; Protein Jade-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function.
  • 基因功能參考文獻：
    1. identification of SNPs within the IQCJ, NXPH1, PHF17 and MYB genes partly explaining the large interindividual variability observed in plasma triglyceride levels in response to an n-3 fatty acid supplementation PMID: 27160456
    2. A genome-wide association study (GWAS) identified loci associated with the plasma triglyceride (TG) response to omega-3 fatty acid (FA) supplementation in IQCJ, NXPH1, PHF17 and MYB. PMID: 28134766
    3. JADE1 expression has a role in colon cancers, renal carcinomas, and in acute kidney injuries and regeneration. (Review) PMID: 27155521
    4. Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis. PMID: 26919559
    5. JADE1S protein localized to centrosomes in interphase and mitotic cells, and to the midbody during cytokinesis. PMID: 26151225
    6. Casein kinase 1 alpha specifically phosphorylates Jade-1 at an unprimed SLS phosphorylation site. PMID: 25100726
    7. Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 shuttling during organ regeneration. PMID: 24739512
    8. lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis. PMID: 24097061
    9. Reduced Jade-1 expression is associated with clear-cell renal cell carcinomas. PMID: 23824745
    10. The ciliary protein nephrocystin-4 translocates the canonical Wnt regulator Jade-1 to the nucleus to negatively regulate beta-catenin signaling. PMID: 22654112
    11. RCC with a low expression of Jade-1 is associated with a poor outcome and decreased survival PMID: 22516360
    12. Jade-1 protein is a novel candidate regulatory factor in Von Hippel Lindau-mediated renal tumor suppression PMID: 12169691
    13. Jade-1 is a novel candidate transcriptional co-activator associated with HAT activity and may play a key role in the pathogenesis of renal cancer and von Hippel-Lindau disease PMID: 15502158
    14. Jade-1 may suppress renal cancer cell growth in part by increasing apoptosis. PMID: 16046545
    15. Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation PMID: 18684714
    16. The pVHL tumour suppressor and the Wnt tumorigenesis pathway are therefore directly linked through Jade-1. PMID: 18806787

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  • 亞細胞定位：
    Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    JADE family
  • 組織特異性：
    Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells.
  • 數據庫鏈接：

    HGNC: 30027

    OMIM: 610514

    KEGG: hsa:79960

    STRING: 9606.ENSP00000226319

    UniGene: Hs.12420



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